Zack Greinke pitched the most innings for the Astros in 2021, with 171 innings.

	NAME	IP	SEASON	TM	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Zack Greinke Z. Greinke	171.0	2021	HOU	30	11	6	.647	29	4.16	120	1	0	0	164	79	82	30	36	2	0	0	697	3	6.32	1.89	3.33	1.58	17.2	5.2	1.17	.263	4.32	97	4.71	111	8.63	-9.1
2	Lance McCullers Jr. L. McCullers Jr.	162.1	2021	HOU	28	13	5	.722	28	3.16	185	0	0	0	122	57	59	13	76	10	0	0	684	7	10.26	4.21	2.43	0.72	27.0	11.1	1.22	.273	3.27	74	3.51	83	6.76	13
3	Luis Garcia L. Garcia	155.1	2021	HOU	30	11	8	.579	28	3.48	167	0	0	0	133	60	62	19	50	3	1	1	633	9	9.68	2.90	3.34	1.10	26.4	7.9	1.18	.289	3.59	81	3.63	86	7.71	10.5
4	Framber Valdez F. Valdez	134.2	2021	HOU	22	11	6	.647	22	3.14	125	1	0	0	110	47	52	12	58	11	0	1	572	9	8.35	3.88	2.16	0.80	21.9	10.1	1.25	.268	3.48	73	4.00	95	7.35	3.4
5	José Urquidy J. Urquidy	107.0	2021	HOU	20	8	3	.727	20	3.62	90	0	0	0	87	43	43	17	19	2	0	0	423	2	7.57	1.60	4.74	1.43	21.3	4.5	0.99	.237	3.62	85	4.13	98	7.32	1.1
6	Jake Odorizzi J. Odorizzi	104.2	2021	HOU	24	6	7	.462	23	4.21	91	0	0	0	97	49	51	16	34	3	0	1	441	0	7.82	2.92	2.68	1.38	20.6	7.7	1.25	.273	4.39	99	4.47	106	8.34	-2.8
7	Cristian Javier C. Javier	101.1	2021	HOU	36	4	1	.800	9	3.55	130	0	0	2	67	40	41	16	53	7	5	1	424	6	11.55	4.71	2.45	1.42	30.7	12.5	1.18	.234	3.64	83	4.43	105	5.95	-2.2
8	Ryne Stanek R. Stanek	68.1	2021	HOU	72	3	5	.375	0	3.42	83	0	0	2	46	26	32	8	37	5	13	3	290	6	10.93	4.87	2.24	1.05	28.6	12.8	1.21	.242	4.21	80	4.10	97	6.06	1
9	Ryan Pressly R. Pressly	64.0	2021	HOU	64	5	3	.625	0	2.25	81	0	0	26	49	16	19	4	13	0	49	1	250	3	11.39	1.83	6.23	0.56	32.4	5.2	0.97	.296	2.67	53	2.05	48	6.89	15.6
10	Brandon Bielak B. Bielak	50.0	2021	HOU	28	3	4	.429	2	4.50	46	0	0	1	48	25	29	5	21	3	6	0	218	4	8.28	3.78	2.19	0.90	21.1	9.6	1.38	.301	5.22	105	4.06	96	8.64	0.9
11	Brooks Raley B. Raley	49.0	2021	HOU	58	2	3	.400	0	4.78	65	0	0	2	43	26	30	6	16	3	9	0	205	1	11.94	2.94	4.06	1.10	31.7	7.8	1.20	.322	5.51	112	3.26	77	7.90	5.3
12	Blake Taylor B. Taylor	42.2	2021	HOU	51	4	4	.500	0	3.16	41	0	0	0	38	15	19	6	22	0	10	2	188	5	8.65	4.64	1.86	1.27	21.8	11.7	1.41	.269	4.01	74	4.62	109	8.02	-1.8
13	Bryan Abreu B. Abreu	36.0	2021	HOU	31	3	3	.500	0	5.75	36	0	0	1	35	23	26	4	18	3	3	0	161	4	9.00	4.50	2.00	1.00	22.4	11.2	1.47	.310	6.50	134	4.36	103	8.75	-0.5
14	Phil Maton P. Maton	25.1	2021	HOU	27	4	0	1.000	0	4.97	24	0	0	0	29	14	15	2	12	3	2	0	119	0	8.53	4.26	2.00	0.71	20.2	10.1	1.62	.346	5.33	116	4.07	96	10.30	0.5
15	Kendall Graveman K. Graveman	23.0	2021	HOU	23	1	1	.500	0	3.13	27	0	0	0	20	8	8	1	12	5	3	1	101	1	10.57	4.70	2.25	0.39	26.7	11.9	1.39	.339	3.13	73	3.60	85	7.83	1.6
16	Joe Smith J. Smith	21.2	2021	HOU	27	1	1	.500	0	7.48	17	0	0	0	35	18	18	4	4	3	10	0	103	2	7.06	1.66	4.25	1.66	16.5	3.9	1.80	.413	7.48	175	4.96	117	14.54	-1.8
17	Yimi García Y. García	21.1	2021	HOU	23	1	2	.333	0	5.48	25	0	0	0	18	13	15	3	5	0	8	0	86	0	10.55	2.11	5.00	1.27	29.1	5.8	1.08	.283	6.33	128	3.35	79	7.59	2.1
18	Andre Scrubb A. Scrubb	19.2	2021	HOU	18	1	1	.500	0	5.03	21	0	0	0	15	11	11	5	14	0	5	0	86	2	9.61	6.41	1.50	2.29	24.4	16.3	1.47	.217	5.03	118	6.47	153	6.86	-4.9
19	Kent Emanuel K. Emanuel	17.2	2021	HOU	10	1	0	1.000	0	2.55	13	0	0	0	12	5	5	4	4	1	5	0	68	0	6.62	2.04	3.25	2.04	19.1	5.9	0.91	.174	2.55	60	5.48	130	6.11	-2.5
20	Peter Solomon P. Solomon	14.0	2021	HOU	6	1	0	1.000	0	1.29	10	0	0	0	10	2	2	0	8	0	3	0	55	2	6.43	5.14	1.25	0.00	18.2	14.5	1.29	.270	1.29	30	3.45	81	6.43	1.2
21	Ralph Garza R. Garza	11.0	2021	HOU	9	1	2	.333	0	4.09	14	0	0	0	11	5	6	2	7	0	8	1	49	1	11.45	5.73	2.00	1.64	28.6	14.3	1.64	.346	4.91	96	4.89	115	9.00	-0.8
22	Enoli Paredes E. Paredes	8.2	2021	HOU	12	0	0		0	6.23	15	0	0	0	7	6	10	0	17	2	1	0	53	1	15.58	17.65	0.88	0.00	28.3	32.1	2.77	.368	10.38	146	6.28	148	7.27	-2
23	Nivaldo Rodriguez N. Rodriguez	7.1	2021	HOU	4	0	0		0	2.45	3	0	0	0	4	2	2	2	4	3	4	0	31	0	3.68	4.91	0.75	2.45	9.7	12.9	1.09	.105	2.45	57	8.75	207	4.91	-3.7
24	Rafael Montero R. Montero	6.0	2021	HOU	4	0	1	.000	0	0.00	5	0	0	0	3	0	1	0	2	0	1	0	21	0	7.50	3.00	2.50	0.00	23.8	9.5	0.83	.214	1.50	0	2.50	59	4.50	1.2
25	Josh James J. James	5.0	2021	HOU	5	0	0		0	5.40	8	0	0	0	4	3	3	1	2	0	5	0	21	2	14.40	3.60	4.00	1.80	38.1	9.5	1.20	.300	5.40	126	3.76	89	7.20	0.3