Since 2000, Bartolo Colon has lost the most games, with 167 games.

Interpreted as:

most regular-season loses by a player since 2000 MLB teams

	NAME	L	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Bartolo Colon B. Colon	167	211	.442	483	.558	472	4.11	2,150	30	10	0	2958.2	3,096	1,351	1,465	388	748	51	2	36	12,487	32	6.54	2.28	2.87	1.18	17.2	6.0	1.30	.296	4.46	96	4.14	97	9.42	44.8
2	CC Sabathia	161	251	.391	561	.609	560	3.74	3,093	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
3	Mark Buehrle M. Buehrle	160	214	.428	518	.572	493	3.81	1,870	33	10	0	3283.1	3,472	1,391	1,542	361	734	79	6	49	13,705	27	5.13	2.01	2.55	0.99	13.6	5.4	1.28	.292	4.23	87	4.11	93	9.52	111.9
4	Justin Verlander J. Verlander	158	265	.374	554	.626	554	3.32	3,546	26	9	0	3561.2	3,041	1,315	1,426	369	1,003	121	0	28	14,583	99	8.96	2.53	3.54	0.93	24.3	6.9	1.14	.280	3.60	79	3.43	81	7.68	312
5	Zack Greinke Z. Greinke	156	225	.409	586	.591	541	3.49	2,979	17	5	1	3389.1	3,207	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
6	A.J. Burnett	155	160	.492	428	.508	423	3.99	2,480	24	10	0	2690.0	2,482	1,194	1,305	260	1,075	143	1	33	11,483	161	8.30	3.60	2.31	0.87	21.6	9.4	1.32	.295	4.37	97	3.85	92	8.30	96.2
7	Livan Hernandez L. Hernandez	150	151	.498	438	.502	394	4.45	1,596	39	9	1	2655.2	2,949	1,312	1,404	297	846	67	17	72	11,472	35	5.41	2.87	1.89	1.01	13.9	7.4	1.43	.306	4.76	105	4.35	102	9.99	-29.4
8	John Lackey J. Lackey	147	188	.439	448	.561	446	3.92	2,294	18	8	0	2840.1	2,862	1,237	1,347	319	815	133	0	32	12,030	125	7.27	2.58	2.81	1.01	19.1	6.8	1.29	.300	4.27	92	3.94	94	9.07	79.6
9	Aaron Harang A. Harang	143	128	.528	387	.472	381	4.26	1,842	15	8	0	2322.0	2,445	1,099	1,177	298	712	63	2	54	9,975	76	7.14	2.76	2.59	1.16	18.5	7.1	1.36	.304	4.56	103	4.17	100	9.48	12.3
10	Kyle Lohse K. Lohse	143	147	.493	457	.507	418	4.40	1,615	12	9	2	2531.2	2,711	1,239	1,327	316	694	87	15	34	10,839	57	5.74	2.47	2.33	1.12	14.9	6.4	1.34	.295	4.72	105	4.35	105	9.64	-58.3
11	Barry Zito B. Zito	143	165	.464	433	.536	421	4.04	1,885	12	5	0	2576.2	2,381	1,157	1,254	282	1,064	97	9	52	11,001	50	6.58	3.72	1.77	0.98	17.1	9.7	1.34	.274	4.38	97	4.38	104	8.32	-43.1
12	Patrick Corbin P. Corbin	141	110	.562	371	.438	352	4.50	1,853	7	2	2	2040.0	2,170	1,020	1,097	284	626	50	10	24	8,772	67	8.17	2.76	2.96	1.25	21.1	7.1	1.37	.316	4.84	107	4.13	99	9.57	9.1
13	James Shields J. Shields	139	145	.489	407	.511	405	4.01	2,234	23	9	0	2616.0	2,581	1,167	1,267	361	746	97	1	22	10,993	107	7.69	2.57	2.99	1.24	20.3	6.8	1.27	.294	4.36	98	4.16	101	8.88	-13.5
14	Derek Lowe D. Lowe	139	165	.457	524	.543	358	4.03	1,513	10	4	67	2370.0	2,475	1,061	1,184	194	704	66	127	58	10,097	44	5.75	2.67	2.15	0.74	15.0	7.0	1.34	.299	4.50	94	3.83	90	9.40	111.4
15	Bronson Arroyo B. Arroyo	137	148	.481	419	.519	383	4.28	1,571	16	6	1	2435.2	2,507	1,158	1,260	347	661	105	6	60	10,338	42	5.80	2.44	2.38	1.28	15.2	6.4	1.30	.282	4.66	100	4.59	108	9.26	-82
16	Javier Vazquez J. Vazquez	137	151	.476	391	.524	385	4.04	2,284	25	7	0	2513.0	2,434	1,129	1,212	322	643	73	4	52	10,504	72	8.18	2.30	3.55	1.15	21.7	6.1	1.22	.294	4.34	91	3.77	86	8.72	179
17	Felix Hernandez F. Hernandez	136	169	.446	419	.554	418	3.42	2,524	25	11	0	2729.2	2,487	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
18	Charlie Morton C. Morton	134	147	.477	415	.523	408	4.13	2,195	3	2	0	2266.1	2,141	1,040	1,139	226	858	200	1	27	9,749	72	8.72	3.41	2.56	0.90	22.5	8.8	1.32	.305	4.52	103	3.89	97	8.50	36.8
19	Kevin Millwood K. Millwood	134	129	.510	375	.490	373	4.26	1,673	17	5	0	2266.2	2,372	1,073	1,165	253	707	65	0	40	9,735	55	6.64	2.81	2.37	1.00	17.2	7.3	1.36	.301	4.63	97	4.07	93	9.42	78.1
20	Edwin Jackson E. Jackson	133	107	.554	412	.446	318	4.78	1,508	5	3	1	1960.0	2,094	1,040	1,135	249	779	39	30	39	8,569	108	6.92	3.58	1.94	1.14	17.6	9.1	1.47	.308	5.21	116	4.47	108	9.62	-74.1
21	Dan Haren D. Haren	131	153	.461	391	.539	380	3.75	2,013	16	6	1	2419.2	2,357	1,009	1,105	305	500	67	4	39	10,022	98	7.49	1.86	4.03	1.13	20.1	5.0	1.18	.288	4.11	92	3.77	92	8.77	92.8
22	Tim Hudson T. Hudson	131	211	.383	461	.617	458	3.50	1,948	25	13	0	2990.1	2,836	1,164	1,263	240	855	120	0	82	12,425	78	5.86	2.57	2.28	0.72	15.7	6.9	1.23	.280	3.80	84	3.79	91	8.54	131.3
23	Ervin Santana E. Santana	129	151	.461	425	.539	386	4.11	1,978	21	11	0	2486.2	2,391	1,135	1,221	331	776	104	20	35	10,482	104	7.16	2.81	2.55	1.20	18.9	7.4	1.27	.282	4.42	99	4.31	104	8.65	-44.1
24	Adam Wainwright A. Wainwright	128	200	.390	478	.610	411	3.53	2,202	28	11	3	2668.1	2,577	1,047	1,117	233	736	81	13	40	11,116	51	7.43	2.48	2.99	0.79	19.8	6.6	1.24	.298	3.77	88	3.53	87	8.69	152.8
25	Jake Peavy J. Peavy	126	152	.453	388	.547	377	3.63	2,207	15	6	0	2377.0	2,134	960	1,011	259	708	78	3	42	9,838	46	8.36	2.68	3.12	0.98	22.4	7.2	1.20	.285	3.83	90	3.64	89	8.08	127.6