Ted Lyons has the most career losses when allowing 7+ runs, with 63 games.

Interpreted as:

most regular-season loses by a player through r 7 or more yes

	NAME	L	R	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Ted Lyons T. Lyons	63	640	9	.875	80	.125	77	9.05	160	35	0	0	530.0	903	533	71	209	9	0		2,692	15	2.72	3.55	0.77	1.21	5.9	7.8	2.10	.371	10.87	15.33
2	Burleigh Grimes B. Grimes	58	601	13	.817	76	.183	74	7.77	158	32	0	0	529.1	840	457	40	247	25	1		2,679	20	2.69	4.20	0.64	0.68	5.9	9.2	2.05	.362	10.22	14.28
3	Earl Whitehill E. Whitehill	53	585	16	.768	77	.232	77	8.96	195	20	0	0	497.1	794	495	51	262	15	0		2,530	11	3.53	4.74	0.74	0.92	7.7	10.4	2.12	.370	10.59	14.37
4	Red Ruffing R. Ruffing	52	574	4	.929	73	.071	73	9.46	217	16	0	0	450.0	743	473	65	224	5	0		2,312	13	4.34	4.48	0.97	1.30	9.4	9.7	2.15	.376	11.48	14.86
5	George Mullin G. Mullin	50	475	5	.909	58	.091	57	2.82	154	41	0	0	443.2	678		15	174	19	0			20	3.12	3.53	0.89	0.30		9.2	1.92	.436	9.64	13.75
6	Casey Patten C. Patten	46	493	6	.885	55	.115	54	5.71	163	46	0	0	444.1	693		24	146	14	1			10	3.30	2.96	1.12	0.49		7.7	1.89	.433	9.99	14.04
7	Livan Hernandez L. Hernandez	44	374	0	1.000	50	.000	50	13.88	142	0	0	0	224.1	438	346	65	129	8	0	10	1,231	6	5.70	5.18	1.10	2.61	11.5	10.5	2.53	.421	15.00	17.57
8	Bobo Newsom B. Newsom	43	464	7	.860	57	.140	57	9.41	197	21	0	0	379.2	588	397	43	255	9	0		1,980	11	4.67	6.04	0.77	1.02	9.9	12.9	2.22	.369	11.00	13.94
9	Jack Powell J. Powell	42	363	2	.955	45	.045	43	3.85	143	34	0	0	348.1	517		22	94	9	1			11	3.69	2.43	1.52	0.57		6.3	1.75	.401	9.38	13.36
10	Tom Hughes T. Hughes	41	418	6	.872	50	.128	49	3.49	187	35	0	0	371.1	553		21	147	27	0			17	4.53	3.56	1.27	0.51		8.8	1.89	.413	10.13	13.40
11	Tim Wakefield T. Wakefield	40	377	2	.952	50	.048	49	12.17	140	1	0	0	229.1	403	310	77	134	19	1	5	1,247	17	5.49	5.26	1.04	3.02	11.2	10.7	2.34	.372	14.80	15.82
12	Chick Fraser C. Fraser	39	406	5	.886	45	.114	44	3.02	161	39	0	0	370.0	506		11	188	34	1			19	3.92	4.57	0.86	0.27		11.1	1.88	.383	9.88	12.31
13	Bartolo Colon B. Colon	38	320	1	.974	42	.026	42	14.36	129	0	0	0	178.0	356	284	72	78	8	0	7	981	0	6.52	3.94	1.65	3.64	13.1	8.0	2.44	.409	16.18	18.00
14	Jamie Moyer J. Moyer	38	333	0	1.000	43	.000	43	13.52	122	0	0	0	198.1	382	298	73	81	14	0	8	1,065	6	5.54	3.68	1.51	3.31	11.5	7.6	2.33	.399	15.11	17.33
15	Wes Ferrell W. Ferrell	38	416	8	.826	52	.174	51	9.66	101	15	0	0	329.0	562	353	53	163	5	1		1,695	4	2.76	4.46	0.62	1.45	6.0	9.6	2.20	.371	11.38	15.37
16	George Uhle G. Uhle	38	395	4	.905	52	.095	51	8.67	110	15	0	0	331.0	574	319	23	130	26	0		1,715	9	2.99	3.53	0.85	0.63	6.4	7.6	2.13	.386	10.74	15.61
17	Sad Sam Jones S. Sam Jones	38	404	6	.864	51	.136	50	8.96	90	15	0	0	321.1	544	320	27	128	9	0		1,609	5	2.52	3.59	0.70	0.76	5.6	8.0	2.09	.382	11.32	15.24
18	Howard Ehmke H. Ehmke	38	397	5	.884	48	.116	46	9.77	129	17	0	0	306.2	532	333	23	162	19	2			7	3.79	4.75	0.80	0.68		10.3	2.26	.413	11.65	15.61
19	Mark Buehrle M. Buehrle	37	339	1	.974	45	.026	45	12.15	122	0	0	0	223.0	449	301	69	85	8	0	11	1,188	5	4.92	3.43	1.44	2.78	10.3	7.2	2.39	.420	13.68	18.12
20	Jack Morris J. Morris	37	343	2	.949	46	.051	46	12.00	137	0	0	0	230.1	396	307	61	146	12	0	13	1,233	25	5.35	5.70	0.94	2.38	11.1	11.8	2.35	.382	13.40	15.47
21	Nolan Ryan N. Ryan	37	301	1	.974	40	.026	40	11.77	226	4	0	0	208.2	314	273	45	146	8	0	12	1,082	18	9.75	6.30	1.55	1.94	20.9	13.5	2.20	.409	12.98	13.54
22	Hooks Dauss H. Dauss	37	370	4	.902	46	.098	44	7.27	112	22	0	0	335.2	510	271	24	158	10	1		1,658	3	3.00	4.24	0.71	0.64	6.8	9.5	1.99	.359	9.92	13.67
23	Tully Sparks T. Sparks	37	321	0	1.000	38	.000	38	3.24	67	30	0	0	283.1	435		11	106	21	0			8	2.13	3.37	0.63	0.35		8.5	1.91	.409	10.20	13.82
24	Randy Johnson R. Johnson	36	296	0	1.000	39	.000	39	12.76	188	2	0	0	187.2	303	266	54	133	13	0	4	993	11	9.02	6.38	1.41	2.59	18.9	13.4	2.32	.412	14.20	14.53
25	Early Wynn E. Wynn	36	318	4	.900	41	.100	41	9.48	114	9	0	0	264.0	435	278	44	135	5	0	4	1,351	6	3.89	4.60	0.84	1.50	8.4	10.0	2.16	.371	10.84	14.83