Aaron Harang, Justin Verlander and Barry Zito were tied for losing the most games in 2008, with 17 games.

	NAME	L	SEASON	TM	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Aaron Harang A. Harang	17	2008	CIN	6	.739	30	.261	29	4.78	153	1	1	0	184.1	205	98	104	35	50	2	0	5	793	2	7.47	2.44	3.06	1.71	19.3	6.3	1.38	.307	5.08	108	4.78	108	10.01	-6.4
2	Justin Verlander J. Verlander	17	2008	DET	11	.607	33	.393	33	4.84	163	1	0	0	201.0	195	108	119	18	87	14	0	8	880	6	7.30	3.90	1.87	0.81	18.5	9.9	1.40	.296	5.33	110	4.17	96	8.73	4.2
3	Barry Zito B. Zito	17	2008	SFG	10	.630	32	.370	32	5.15	120	0	0	0	180.0	186	103	115	16	102	4	0	10	818	3	6.00	5.10	1.18	0.80	14.7	12.5	1.60	.295	5.75	120	4.71	111	9.30	-10
4	Brian Bannister B. Bannister	16	2008	KCR	9	.640	32	.360	32	5.76	113	1	0	0	182.2	215	117	127	29	58	7	0	1	811	7	5.57	2.86	1.95	1.43	13.9	7.2	1.49	.308	6.26	130	5.02	117	10.59	-15.3
5	Greg Smith G. Smith	16	2008	OAK	7	.696	32	.304	32	4.16	111	2	0	0	190.1	169	88	92	21	87	3	0	5	800	5	5.25	4.11	1.28	0.99	13.9	10.9	1.35	.256	4.35	99	4.81	114	7.99	-12.7
6	Javier Vazquez J. Vazquez	16	2008	CWS	12	.571	33	.429	33	4.67	200	1	0	0	208.1	214	108	113	25	61	6	0	2	890	2	8.64	2.64	3.28	1.08	22.5	6.9	1.32	.316	4.88	103	3.73	82	9.24	18.1
7	John Lannan J. Lannan	15	2008	WSH	9	.625	31	.375	31	3.91	117	0	0	0	182.0	172	79	89	23	72	7	0	1	779	6	5.79	3.56	1.63	1.14	15.0	9.2	1.34	.266	4.40	91	4.78	110	8.51	-8.5
8	Carlos Silva C. Silva	15	2008	SEA	4	.789	28	.211	28	6.46	69	1	0	0	153.1	213	110	114	20	32	4	0	2	689	1	4.05	1.88	2.16	1.17	10.0	4.6	1.60	.342	6.69	155	4.62	109	12.50	-7
9	Brandon Backe B. Backe	14	2008	HOU	9	.609	31	.391	31	6.05	127	0	0	0	166.2	202	112	114	36	77	4	0	2	756	2	6.86	4.16	1.65	1.94	16.8	10.2	1.67	.324	6.16	144	5.87	135	10.91	-27.6
10	Miguel Batista M. Batista	14	2008	SEA	4	.778	44	.222	20	6.26	73	0	0	1	115.0	135	80	89	19	79	6	9	6	556	5	5.71	6.18	0.92	1.49	13.1	14.2	1.86	.306	6.97	150	6.22	147	10.57	-26
11	Matt Cain M. Cain	14	2008	SFG	8	.636	34	.364	34	3.76	186	1	1	0	217.2	206	91	95	19	91	7	0	9	933	7	7.69	3.76	2.04	0.79	19.9	9.8	1.36	.297	3.93	88	3.90	92	8.52	7.9
12	Johnny Cueto J. Cueto	14	2008	CIN	9	.609	31	.391	31	4.81	158	0	0	0	174.0	178	93	101	29	68	14	0	1	769	6	8.17	3.52	2.32	1.50	20.5	8.8	1.41	.298	5.22	109	4.89	110	9.21	-8.1
13	Zach Duke Z. Duke	14	2008	PIT	5	.737	31	.263	31	4.82	87	1	1	0	185.0	230	99	111	19	47	7	0	1	829	2	4.23	2.29	1.85	0.92	10.5	5.7	1.50	.315	5.40	113	4.39	103	11.19	-2.6
14	Braden Looper B. Looper	14	2008	STL	12	.538	33	.462	33	4.16	108	1	1	0	199.0	216	92	101	25	45	11	0	1	842	3	4.88	2.04	2.40	1.13	12.8	5.3	1.31	.292	4.57	100	4.52	107	9.77	-6.7
15	Andy Pettitte A. Pettitte	14	2008	NYY	14	.500	33	.500	33	4.54	158	0	0	0	204.0	233	103	112	19	55	7	0	4	881	6	6.97	2.43	2.87	0.84	17.9	6.2	1.41	.333	4.94	105	3.70	86	10.28	14.1
16	Jarrod Washburn J. Washburn	14	2008	SEA	5	.737	28	.263	26	4.69	87	1	0	1	153.2	174	80	87	19	50	7	1	2	675	2	5.10	2.93	1.74	1.11	12.9	7.4	1.46	.303	5.10	112	4.71	111	10.19	-8.5
17	Greg Maddux G. Maddux	13	2008	TOT	8	.619	33	.381	33	4.22	98	0	0	0	194.0	204	91	105	21	30	6	0	5	804	2	4.55	1.39	3.27	0.97	12.2	3.7	1.21	.282	4.87	105	4.08	97	9.46	2.6
18	Brett Myers B. Myers	13	2008	PHI	10	.565	30	.435	30	4.55	163	2	1	0	190.0	197	96	103	29	65	6	0	6	817	2	7.72	3.08	2.51	1.37	20.0	8.0	1.38	.303	4.88	105	4.51	104	9.33	-3.2
19	Kenny Rogers K. Rogers	13	2008	DET	9	.591	30	.409	30	5.70	82	0	0	0	173.2	212	110	118	22	71	9	0	3	782	4	4.25	3.68	1.15	1.14	10.5	9.1	1.63	.318	6.12	130	5.21	119	10.99	-16.1
20	Joe Blanton J. Blanton	12	2008	TOT	9	.571	33	.429	33	4.69	111	0	0	0	197.2	211	103	110	22	66	4	0	3	855	2	5.05	3.01	1.68	1.00	13.0	7.7	1.40	.290	5.01	110	4.51	105	9.61	-5.2
21	Mark Buehrle M. Buehrle	12	2008	CWS	15	.444	34	.556	34	3.79	140	1	0	0	218.2	240	92	106	22	52	5	0	4	918	4	5.76	2.14	2.69	0.91	15.3	5.7	1.34	.312	4.36	84	3.93	87	9.88	14.3
22	Paul Byrd P. Byrd	12	2008	TOT	11	.522	30	.478	30	4.60	82	1	0	0	180.0	204	92	96	31	34	7	0	0	761	0	4.10	1.70	2.41	1.55	10.8	4.5	1.32	.285	4.80	105	5.13	122	10.20	-18.9
23	Jeremy Guthrie J. Guthrie	12	2008	BAL	10	.545	30	.455	30	3.63	120	1	0	0	190.2	176	77	82	24	58	7	0	2	796	3	5.66	2.74	2.07	1.13	15.1	7.3	1.23	.259	3.87	82	4.52	101	8.31	-0.4
24	Luke Hochevar L. Hochevar	12	2008	KCR	6	.667	22	.333	22	5.51	72	0	0	0	129.0	143	79	84	12	47	5	0	1	566	7	5.02	3.28	1.53	0.84	12.7	8.3	1.47	.305	5.86	124	4.43	104	9.98	-2.3
25	Ubaldo Jimenez U. Jimenez	12	2008	COL	12	.500	34	.500	34	3.99	172	1	0	0	198.2	182	88	97	11	103	10	0	4	868	16	7.79	4.67	1.67	0.50	19.8	11.9	1.43	.299	4.39	86	3.82	85	8.24	14.5