Since 1970, Nolan Ryan has lost the most games, with 279 games.

Interpreted as:

most regular-season losses by a pitcher since 1970

	NAME	L	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Nolan Ryan N. Ryan	279	312	.472	759	.528	744	3.18	5,483	217	61	2	5159.2	3,765	1,825	2,085	305	2,664	153	8	70	21,624	268	9.56	4.65	2.06	0.53	25.4	12.3	1.25	.266	3.64	89	2.96	82	6.57	371.5
2	Bert Blyleven B. Blyleven	250	287	.466	692	.534	685	3.31	3,701	242	60	0	4970.0	4,632	1,830	2,029	430	1,322	155	3	71	20,491	114	6.70	2.39	2.80	0.78	18.1	6.5	1.20	.282	3.67	85	3.18	82	8.39	368.6
3	Frank Tanana F. Tanana	236	240	.496	638	.504	616	3.66	2,773	143	34	1	4188.1	4,063	1,704	1,910	448	1,255	129	10	116	17,641	119	5.96	2.70	2.21	0.96	15.7	7.1	1.27	.277	4.10	94	3.78	96	8.73	66.4
4	Phil Niekro P. Niekro	234	264	.470	662	.530	626	3.51	2,806	199	35	9	4516.0	4,281	1,759	2,023	426	1,596	100	23	65	19,074	163	5.59	3.18	1.76	0.85	14.7	8.4	1.30	.273	4.03	89	3.75	96	8.53	79.6
5	Greg Maddux G. Maddux	227	355	.390	744	.610	740	3.16	3,371	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
6	Charlie Hough C. Hough	216	216	.500	858	.500	440	3.75	2,362	107	13	61	3801.1	3,283	1,582	1,807	383	1,665	174	240	44	16,170	179	5.59	3.94	1.42	0.91	14.6	10.3	1.30	.250	4.28	95	4.28	109	7.77	-142.3
7	Steve Carlton S. Carlton	210	282	.427	622	.573	606	3.30	3,550	219	45	1	4479.1	4,017	1,641	1,877	373	1,591	43	6	137	18,632	157	7.13	3.20	2.23	0.75	19.1	8.5	1.25	.279	3.77	88	3.23	87	8.07	225.9
8	Jamie Moyer J. Moyer	209	269	.437	696	.563	638	4.25	2,441	33	10	0	4074.0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	97	4.46	102	9.35	-33.5
9	Tom Glavine T. Glavine	203	305	.400	682	.600	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	86	3.94	94	8.76	120.1
10	Don Sutton D. Sutton	196	273	.418	624	.582	619	3.26	2,817	143	47	3	4323.0	3,829	1,564	1,729	404	1,084	68	4	67	17,680	91	5.86	2.26	2.60	0.84	15.9	6.1	1.14	.257	3.60	89	3.35	91	7.97	148.3
11	Dennis Martinez D. Martinez	193	245	.441	692	.559	562	3.70	2,149	122	30	8	3999.2	3,897	1,643	1,835	372	1,165	122	51	71	16,754	83	4.84	2.62	1.84	0.84	12.8	7.0	1.27	.272	4.13	94	3.91	99	8.77	17
12	Rick Reuschel R. Reuschel	191	214	.472	557	.528	529	3.37	2,015	102	26	5	3548.1	3,588	1,330	1,494	221	935	88	16	117	14,888	89	5.11	2.37	2.16	0.56	13.5	6.3	1.27	.290	3.79	89	3.21	85	9.10	225.7
13	Jerry Reuss J. Reuss	191	219	.466	627	.534	546	3.64	1,904	127	39	11	3662.2	3,732	1,483	1,700	245	1,124	57	41	118	15,555	107	4.68	2.76	1.69	0.60	12.2	7.2	1.33	.285	4.18	100	3.45	95	9.17	68.7
14	Bartolo Colon B. Colon	188	247	.432	565	.568	552	4.12	2,535	38	13	0	3461.2	3,593	1,584	1,719	439	948	64	2	47	14,655	45	6.59	2.46	2.67	1.14	17.3	6.5	1.31	.296	4.47	95	4.14	96	9.34	71.6
15	Mike Morgan M. Morgan	186	141	.569	597	.431	411	4.23	1,403	46	10	8	2772.1	2,943	1,303	1,431	270	938	73	56	77	11,872	105	4.55	3.05	1.50	0.88	11.8	7.9	1.40	.291	4.65	102	4.26	103	9.55	-36.8
16	Jack Morris J. Morris	186	254	.423	549	.577	527	3.90	2,478	175	28	0	3824.0	3,567	1,657	1,815	389	1,390	58	10	99	16,120	206	5.83	3.27	1.78	0.92	15.4	8.6	1.30	.269	4.27	96	3.93	95	8.40	93
17	Jerry Koosman J. Koosman	186	186	.500	536	.500	458	3.52	2,187	107	20	17	3312.1	3,205	1,296	1,453	257	1,042	59	42	99	13,876	74	5.94	2.83	2.10	0.70	15.8	7.5	1.28	.285	3.95	95	3.32	90	8.71	135.3
18	Roger Clemens R. Clemens	184	354	.342	709	.658	707	3.12	4,672	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
19	Danny Darwin D. Darwin	182	171	.516	716	.484	371	3.84	1,942	53	9	32	3016.2	2,951	1,286	1,431	321	874	81	171	101	12,716	52	5.79	2.61	2.22	0.96	15.3	6.9	1.27	.277	4.27	95	3.89	97	8.80	25.3
20	Gaylord Perry G. Perry	181	219	.453	488	.548	485	3.18	2,300	215	39	1	3664.1	3,424	1,294	1,490	281	949	71	3	87	15,021	98	5.65	2.33	2.42	0.69	15.3	6.3	1.19	.275	3.66	85	3.18	85	8.41	220.1
21	Tim Wakefield T. Wakefield	180	200	.474	627	.526	463	4.41	2,156	33	6	22	3226.1	3,152	1,582	1,791	418	1,205	186	78	33	13,939	134	6.01	3.36	1.79	1.17	15.5	8.6	1.35	.274	5.00	96	4.72	108	8.79	-137.5
22	Livan Hernandez L. Hernandez	177	178	.499	519	.501	474	4.44	1,976	50	9	1	3189.0	3,525	1,572	1,686	362	1,066	78	17	86	13,816	41	5.58	3.01	1.85	1.02	14.3	7.7	1.44	.306	4.76	105	4.39	103	9.95	-45.4
23	Mike Moore M. Moore	176	161	.522	450	.478	440	4.39	1,667	79	16	2	2831.2	2,858	1,381	1,516	291	1,156	55	6	61	12,203	135	5.30	3.67	1.44	0.92	13.7	9.5	1.42	.284	4.82	105	4.26	101	9.08	-13.9
24	Doyle Alexander D. Alexander	174	194	.473	561	.527	464	3.76	1,528	98	18	3	3367.2	3,376	1,406	1,541	324	978	53	56	60	14,162	74	4.08	2.61	1.56	0.87	10.8	6.9	1.29	.271	4.12	98	3.94	103	9.02	-39.5
25	Fergie Jenkins F. Jenkins	174	215	.447	475	.553	462	3.46	2,263	202	35	0	3395.1	3,216	1,307	1,454	375	724	66	8	74	13,940	46	6.00	1.92	3.13	0.99	16.2	5.2	1.16	.270	3.85	89	3.40	89	8.52	156.1

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DATE	MATCHUP			TIME (ET)
Tue 5/26	HOU	@	TEX	8:05 PM
Wed 5/27	HOU	@	TEX	8:05 PM
Thu 5/28	HOU	@	TEX	8:05 PM
Fri 5/29	MIL	@	HOU	8:10 PM
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Mon 5/25	SEA	@	ATH	9:40 PM
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Since 1970, Nolan Ryan has lost the most games, with 279 games.

Interpreted as:

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