The Houston Astros lost the most games by a team in 2012, with 107 losses.

	TEAM	L	SEASON	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	107	2012	55	.660	162	.340	5,407	583	1,276	238	28	146	545	463	58	1,365	105	46	6,012	2,008	412	54	30	19	114	.236	.302	.371	.673
2	Cubs	101	2012	61	.623	162	.377	5,411	613	1,297	265	36	137	570	447	43	1,235	94	45	5,967	2,045	438	42	24	29	125	.240	.302	.378	.680
3	Rockies	98	2012	64	.605	162	.395	5,577	758	1,526	306	52	166	716	450	36	1,213	100	40	6,176	2,434	524	74	39	34	132	.274	.330	.436	.766
4	Twins	96	2012	66	.593	162	.407	5,562	701	1,448	270	30	131	666	505	53	1,069	135	37	6,209	2,171	431	33	56	28	149	.260	.325	.390	.715
5	Indians	94	2012	68	.580	162	.420	5,525	667	1,385	266	24	136	635	555	59	1,087	110	44	6,195	2,107	426	17	39	28	141	.251	.324	.381	.705
6	Red Sox	93	2012	69	.574	162	.426	5,604	734	1,459	339	16	165	695	428	45	1,197	97	31	6,166	2,325	520	34	55	27	105	.260	.315	.415	.730
7	Marlins	93	2012	69	.574	162	.426	5,437	609	1,327	261	39	137	576	484	35	1,228	149	41	6,056	2,077	437	60	40	46	114	.244	.308	.382	.690
8	Royals	90	2012	72	.556	162	.444	5,636	676	1,492	295	37	131	643	404	42	1,032	132	38	6,149	2,254	463	26	41	35	130	.265	.317	.400	.716
9	Blue Jays	89	2012	73	.549	162	.451	5,487	716	1,346	247	22	198	677	473	55	1,251	123	41	6,093	2,231	467	33	45	29	109	.245	.309	.407	.716
10	Mets	88	2012	74	.543	162	.457	5,450	650	1,357	286	21	139	625	503	42	1,250	79	38	6,089	2,102	446	64	30	43	118	.249	.316	.386	.701
11	Mariners	87	2012	75	.537	162	.463	5,494	619	1,285	241	27	149	584	466	30	1,259	104	35	6,057	2,027	417	32	35	21	95	.234	.296	.369	.665
12	Padres	86	2012	76	.531	162	.469	5,422	651	1,339	272	43	121	610	539	54	1,238	155	46	6,112	2,060	436	63	34	36	100	.247	.319	.380	.699
13	Pirates	83	2012	79	.512	162	.488	5,412	651	1,313	241	37	170	620	444	51	1,354	73	52	6,014	2,138	448	62	45	32	98	.243	.304	.395	.699
14	Phillies	81	2012	81	.500	162	.500	5,544	684	1,414	271	28	158	659	454	63	1,094	116	23	6,172	2,215	457	72	39	41	114	.255	.317	.400	.716
15	Diamondbacks	81	2012	81	.500	162	.500	5,462	734	1,416	307	33	165	710	539	41	1,266	93	51	6,148	2,284	505	61	45	47	108	.259	.328	.418	.746
16	Brewers	79	2012	83	.488	162	.512	5,557	776	1,442	300	39	202	741	466	90	1,240	158	39	6,224	2,426	541	76	35	35	111	.259	.325	.437	.762
17	White Sox	77	2012	85	.475	162	.525	5,518	748	1,409	228	29	211	726	461	65	1,203	109	43	6,111	2,328	468	31	36	24	112	.255	.318	.422	.740
18	Dodgers	76	2012	86	.469	162	.531	5,438	637	1,369	269	23	116	607	481	52	1,156	104	44	6,091	2,032	408	82	38	49	139	.252	.317	.374	.690
19	Cardinals	74	2012	88	.457	162	.543	5,622	765	1,526	290	37	159	732	533	53	1,192	91	37	6,326	2,367	486	69	49	45	135	.271	.338	.421	.759
20	Tigers	74	2012	88	.457	162	.543	5,476	726	1,467	279	39	163	698	511	57	1,103	59	23	6,119	2,313	481	36	39	46	156	.268	.335	.422	.757
21	Angels	73	2012	89	.451	162	.549	5,536	767	1,518	273	22	187	732	449	47	1,113	134	33	6,120	2,396	482	47	41	29	138	.274	.332	.433	.764
22	Rays	72	2012	90	.444	162	.556	5,398	697	1,293	250	30	175	665	571	58	1,323	134	44	6,103	2,128	455	34	42	26	133	.240	.317	.394	.711
23	Orioles	69	2012	93	.426	162	.574	5,560	712	1,375	270	16	214	677	480	50	1,315	58	29	6,158	2,319	500	38	30	24	152	.247	.311	.417	.728
24	Rangers	69	2012	93	.426	162	.574	5,590	808	1,526	303	32	200	780	478	57	1,103	91	44	6,214	2,493	535	36	53	44	121	.273	.334	.446	.780
25	Braves	68	2012	94	.420	162	.580	5,425	700	1,341	263	30	149	660	567	34	1,289	101	32	6,125	2,111	442	53	46	37	108	.247	.320	.389	.709