Between the 2000 and 2009 seasons, Livan Hernandez lost the most games, with 124 games.

Interpreted as:

most regular-season losses for a pitcher 2000 to 2009

	NAME	L	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Livan Hernandez L. Hernandez	124	129	.490	332	.510	332	4.46	1,335	36	7	0	2201.1	2,450	1,091	1,165	250	720	57	0	57	9,533	29	5.46	2.94	1.85	1.02	14.0	7.6	1.44	.307	4.76	104	4.40	102	10.02	-19.5
2	Javier Vazquez J. Vazquez	116	128	.475	328	.525	327	3.98	2,001	23	6	0	2163.0	2,101	957	1,025	269	528	64	0	40	9,023	59	8.33	2.20	3.79	1.12	22.2	5.9	1.22	.297	4.26	89	3.66	82	8.74	195
3	Jeff Suppan J. Suppan	110	115	.489	324	.511	321	4.55	1,079	11	4	0	1965.2	2,168	993	1,093	260	683	83	0	47	8,608	70	4.94	3.13	1.58	1.19	12.5	7.9	1.45	.293	5.00	102	4.87	110	9.93	-92
4	Jeff Weaver J. Weaver	106	90	.541	282	.459	245	4.58	1,074	16	7	2	1630.0	1,773	830	889	195	440	106	11	37	7,056	37	5.93	2.43	2.44	1.08	15.2	6.2	1.36	.301	4.91	105	4.31	98	9.79	12.1
5	Barry Zito B. Zito	106	133	.444	321	.556	320	3.84	1,501	10	4	0	1999.0	1,775	852	929	209	826	81	0	36	8,484	36	6.76	3.72	1.82	0.94	17.7	9.7	1.30	.267	4.18	88	4.29	98	7.99	23.4
6	Kevin Millwood K. Millwood	103	115	.472	307	.528	305	4.18	1,398	15	4	0	1860.2	1,923	865	937	201	578	56	0	35	7,982	41	6.76	2.80	2.42	0.97	17.5	7.2	1.34	.300	4.53	94	4.00	90	9.30	87.6
7	Jon Garland J. Garland	102	117	.466	311	.534	288	4.42	960	10	6	1	1829.1	1,944	898	992	228	593	53	9	27	7,827	40	4.72	2.92	1.62	1.12	12.3	7.6	1.39	.286	4.88	97	4.71	103	9.56	-22.8
8	Greg Maddux G. Maddux	101	134	.430	308	.570	308	3.70	1,211	16	7	0	1939.2	1,965	797	877	196	308	57	0	59	7,964	24	5.62	1.43	3.93	0.91	15.2	3.9	1.17	.286	4.07	86	3.70	85	9.12	147.3
9	Jarrod Washburn J. Washburn	101	97	.510	281	.490	279	4.03	1,016	9	4	1	1728.0	1,724	774	824	223	516	61	1	20	7,308	28	5.29	2.69	1.97	1.16	13.9	7.1	1.30	.273	4.29	92	4.58	104	8.98	-38.7
10	Derek Lowe D. Lowe	99	130	.432	410	.568	270	3.81	1,177	9	3	66	1833.2	1,863	776	885	149	519	54	115	39	7,746	32	5.78	2.55	2.27	0.73	15.2	6.7	1.30	.293	4.34	86	3.79	87	9.14	114.6
11	Kip Wells K. Wells	98	63	.609	282	.391	205	4.73	915	3	2	2	1265.1	1,316	665	733	143	600	66	24	52	5,648	62	6.51	4.27	1.53	1.02	16.2	10.6	1.51	.299	5.21	109	4.66	107	9.36	-42.2
12	Mark Buehrle M. Buehrle	97	135	.418	326	.582	301	3.80	1,188	24	8	0	2061.0	2,143	871	973	236	470	52	6	35	8,562	17	5.19	2.05	2.53	1.03	13.9	5.5	1.27	.288	4.25	82	4.16	90	9.36	106
13	Doug Davis D. Davis	97	90	.519	287	.481	269	4.26	1,206	7	3	0	1629.0	1,687	771	837	169	736	39	4	26	7,162	60	6.66	4.07	1.64	0.93	16.8	10.3	1.49	.303	4.62	94	4.38	98	9.32	19.5
14	Tim Wakefield T. Wakefield	95	110	.463	346	.537	250	4.33	1,209	7	0	7	1747.0	1,664	840	928	224	616	107	30	18	7,477	71	6.23	3.17	1.96	1.15	16.2	8.2	1.31	.271	4.78	93	4.60	106	8.57	-55.8
15	Jamie Moyer J. Moyer	94	140	.402	321	.598	315	4.23	1,178	11	3	0	1980.1	2,025	931	989	270	550	80	2	31	8,414	21	5.35	2.50	2.14	1.23	14.0	6.5	1.30	.277	4.49	97	4.61	105	9.20	-46.8
16	Sidney Ponson S. Ponson	92	71	.564	235	.436	226	5.05	834	23	4	0	1415.1	1,620	794	851	169	487	41	2	15	6,191	45	5.30	3.10	1.71	1.07	13.5	7.9	1.49	.311	5.41	114	4.55	101	10.30	-5.9
17	Miguel Batista M. Batista	91	84	.520	414	.480	201	4.54	907	8	3	38	1441.2	1,507	727	806	150	637	53	111	31	6,353	79	5.66	3.98	1.42	0.94	14.3	10.0	1.49	.295	5.03	100	4.61	103	9.41	-22.7
18	Kyle Lohse K. Lohse	90	84	.517	274	.483	250	4.68	930	7	5	0	1481.2	1,638	770	821	191	450	62	10	25	6,433	47	5.65	2.73	2.07	1.16	14.5	7.0	1.41	.301	4.99	105	4.53	105	9.95	-34
19	Steve Trachsel S. Trachsel	90	83	.520	233	.480	231	4.42	762	9	5	0	1354.2	1,428	665	724	179	531	25	1	33	5,876	35	5.06	3.53	1.44	1.19	13.0	9.0	1.45	.285	4.81	102	4.90	111	9.49	-76.9
20	Andy Pettitte A. Pettitte	89	148	.376	303	.624	300	3.90	1,441	11	3	0	1882.0	1,975	815	917	165	545	32	1	29	8,008	31	6.89	2.61	2.64	0.79	18.0	6.8	1.34	.311	4.39	87	3.61	81	9.44	179.8
21	Jason Johnson J. Johnson	88	46	.657	217	.343	187	4.91	700	6	1	0	1175.2	1,317	641	715	154	415	51	8	25	5,180	58	5.36	3.18	1.69	1.18	13.5	8.0	1.47	.301	5.47	111	4.74	106	10.08	-35.1
22	Tom Glavine T. Glavine	87	118	.424	283	.576	283	3.77	948	11	7	0	1753.2	1,769	734	790	178	600	30	0	59	7,431	10	4.87	3.08	1.58	0.91	12.8	8.1	1.35	.280	4.05	89	4.39	101	9.08	-6.9
23	Mike Mussina M. Mussina	87	134	.394	283	.606	282	3.87	1,488	18	9	0	1790.2	1,801	769	828	194	364	41	0	14	7,379	35	7.48	1.83	4.09	0.98	20.2	4.9	1.21	.304	4.16	86	3.50	78	9.05	192.8
24	Mark Redman M. Redman	85	67	.559	214	.441	202	4.82	736	12	2	0	1226.0	1,347	656	699	138	400	34	4	19	5,306	58	5.40	2.94	1.84	1.01	13.9	7.5	1.42	.302	5.13	108	4.38	100	9.89	0.3
25	Vicente Padilla V. Padilla	84	98	.462	300	.538	221	4.31	977	3	3	2	1415.0	1,460	677	742	159	504	99	21	38	6,146	37	6.21	3.21	1.94	1.01	15.9	8.2	1.39	.295	4.72	97	4.43	101	9.29	-3.6