Nolan Ryan had the most losses when allowing 1+ run, with 292 games.

Interpreted as:

most regular-season losses by a player in 1 or more run games

	NAME	L	R	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	292	2,178	222	.568	672	.432	657	3.85	4,638	161	0	1	4462.2	3,587	1,911	321	2,412	142	5	74	19,166	256	9.35	4.86	1.92	0.65	24.2	12.6	1.34	.280	4.39	7.23
2	Walter Johnson W. Johnson	279	1,902	271	.507	612	.493	547	2.14	2,701	421	0	11	4687.0	4,313		97	1,175	180	59			136	5.19	2.26	2.30	0.19		6.1	1.17	.280	3.65	8.28
3	Phil Niekro P. Niekro	274	2,337	245	.528	707	.472	650	3.85	2,887	200	0	2	4702.0	4,699	2,012	482	1,624	117	22	82	20,099	208	5.53	3.11	1.78	0.92	14.4	8.1	1.34	.281	4.47	8.99
4	Gaylord Perry G. Perry	265	2,128	248	.517	665	.483	626	3.54	3,080	250	0	0	4688.1	4,607	1,846	399	1,253	96	13	157	19,568	150	5.91	2.41	2.46	0.77	15.7	6.4	1.25	.285	4.09	8.84
5	Don Sutton D. Sutton	256	2,104	248	.508	675	.492	670	3.80	3,066	120	0	0	4528.1	4,291	1,914	472	1,195	76	3	86	18,884	104	6.09	2.38	2.57	0.94	16.2	6.3	1.21	.271	4.18	8.53
6	Eppa Rixey E. Rixey	251	1,993	215	.539	585	.461	515	3.51	1,196	252	0	4	4025.0	4,366	1,571	93	989	75	43		17,055	91	2.67	2.21	1.21	0.21	7.0	5.8	1.33	.291	4.46	9.76
7	Bert Blyleven B. Blyleven	250	2,029	216	.536	613	.464	609	3.82	3,199	182	0	0	4312.2	4,291	1,830	430	1,199	137	2	65	18,120	107	6.68	2.50	2.67	0.90	17.7	6.6	1.27	.294	4.23	8.95
8	Robin Roberts R. Roberts	245	1,962	234	.511	587	.489	562	3.79	2,115	260	0	2	4215.0	4,314	1,773	505	837	50	13	69	17,514	31	4.52	1.79	2.53	1.08	12.1	4.8	1.22	.272	4.19	9.21
9	Warren Spahn W. Spahn	245	2,018	297	.452	637	.548	602	3.52	2,231	319	0	2	4609.2	4,502	1,801	434	1,310	41	25	55	19,273	73	4.36	2.56	1.70	0.85	11.6	6.8	1.26	.267	3.94	8.79
10	Steve Carlton S. Carlton	244	2,130	262	.482	647	.518	631	3.69	3,619	199	0	1	4541.1	4,340	1,864	414	1,673	46	4	142	19,245	169	7.17	3.32	2.16	0.82	18.8	8.7	1.32	.291	4.22	8.60
11	Early Wynn E. Wynn	244	2,037	240	.504	589	.496	557	4.04	2,039	240	0	2	3997.2	4,025	1,793	339	1,604	57	27	34	17,329	45	4.59	3.61	1.27	0.76	11.8	9.3	1.41	.277	4.59	9.06
12	Jim Kaat J. Kaat	237	2,038	230	.507	682	.493	577	3.97	2,165	149	0	1	3936.2	4,242	1,738	395	981	113	31	100	16,839	115	4.95	2.24	2.21	0.90	12.9	5.8	1.33	.292	4.66	9.70
13	Frank Tanana F. Tanana	236	1,910	190	.554	570	.446	562	4.13	2,384	109	0	0	3706.1	3,797	1,702	448	1,135	124	3	103	15,855	105	5.79	2.76	2.10	1.09	15.0	7.2	1.33	.285	4.64	9.22
14	Tommy John T. John	231	2,017	218	.514	647	.486	623	3.91	1,895	116	0	0	4024.2	4,384	1,749	302	1,129	87	4	94	17,194	171	4.24	2.52	1.68	0.68	11.0	6.6	1.37	.296	4.51	9.80
15	Bob Friend B. Friend	230	1,652	153	.601	502	.399	459	4.10	1,509	127	0	1	3153.0	3,491	1,436	286	803	44	19	104	13,520	47	4.31	2.29	1.88	0.82	11.2	5.9	1.36	.295	4.72	9.96
16	Ted Lyons T. Lyons	230	2,055	227	.503	517	.497	457	3.98	999	329	0	4	3833.1	4,309	1,696	221	1,064	30	45		16,616	53	2.35	2.50	0.94	0.52	6.0	6.4	1.40	.286	4.82	10.12
17	Greg Maddux G. Maddux	227	1,981	265	.461	635	.539	632	3.76	2,811	74	0	0	4199.2	4,271	1,756	353	892	120	3	162	17,510	66	6.02	1.91	3.15	0.76	16.1	5.1	1.23	.294	4.25	9.15
18	Fergie Jenkins F. Jenkins	226	1,853	227	.499	568	.501	535	3.81	2,781	218	0	0	3947.0	3,857	1,669	484	900	78	14	107	16,405	59	6.34	2.05	3.09	1.10	17.0	5.5	1.21	.277	4.23	8.79
19	Red Ruffing R. Ruffing	225	2,117	221	.504	535	.496	488	4.29	1,738	290	0	4	3845.2	4,043	1,835	254	1,424	54	33		16,734	44	4.07	3.33	1.22	0.59	10.4	8.5	1.42	.286	4.95	9.46
20	Bobo Newsom B. Newsom	222	1,908	174	.561	505	.439	451	4.42	1,872	215	0	2	3387.1	3,588	1,664	207	1,605	58	27		15,098	53	4.97	4.26	1.17	0.55	12.4	10.6	1.53	.298	5.07	9.53
21	Sad Sam Jones S. Sam Jones	217	2,007	184	.541	542	.459	450	4.35	1,086	214	0	9	3427.2	3,847	1,657	154	1,269	67	59		15,060	70	2.85	3.33	0.86	0.40	7.2	8.4	1.49	.296	5.27	10.10
22	Jack Quinn J. Quinn	217	1,835	188	.536	568	.464	413	3.24	1,129	214	0	7	3390.0	3,903		102	763	84	92			53	3.00	2.03	1.48	0.27		5.6	1.38	.328	4.87	10.36
23	Charlie Hough C. Hough	216	1,807	162	.571	596	.429	417	4.48	1,924	94	0	12	3180.0	3,015	1,582	383	1,430	147	83	35	13,847	160	5.45	4.05	1.35	1.08	13.9	10.3	1.40	.264	5.11	8.53
24	Red Faber R. Faber	213	1,816	207	.507	553	.493	451	3.53	1,303	244	0	9	3642.0	3,867	1,430	112	1,110	99	66		15,638	49	3.22	2.74	1.17	0.28	8.3	7.1	1.37	.289	4.49	9.56
25	Paul Derringer P. Derringer	212	1,653	181	.539	475	.461	413	3.91	1,312	219	0	5	3227.0	3,677	1,401	159	708	29	39		13,909	49	3.66	1.97	1.85	0.44	9.4	5.1	1.36	.301	4.61	10.26