Nolan Ryan has the most career losses in losses, with 292 games.

Interpreted as:

most regular-season losses without a win by a pitcher

	NAME	W	L	L%	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	0	292	1.000	.000	483	455	4.81	2,912	59	0	3	2801.2	2,510	1,496	1,699	247	1,662	96	9	66	12,456	190	9.35	5.34	1.75	0.79	23.4	13.3	1.49	.300	5.46	8.06
2	Walter Johnson W. Johnson	0	279	1.000	.000	385	290	2.77	1,345	192	1	34	2395.1	2,478		1,287	54	669	109	87			79	5.05	2.51	2.01	0.20		6.6	1.31	.305	4.84	9.31
3	Phil Niekro P. Niekro	0	274	1.000	.000	546	414	4.75	1,776	65	0	29	2872.2	3,168	1,515	1,764	335	1,100	67	69	75	12,688	150	5.56	3.45	1.61	1.05	14.0	8.7	1.49	.301	5.53	9.93
4	Gaylord Perry G. Perry	0	265	1.000	.000	463	385	4.64	1,772	77	0	10	2702.0	3,033	1,393	1,596	292	828	68	28	135	11,741	108	5.90	2.76	2.14	0.97	15.1	7.1	1.43	.312	5.32	10.10
5	Don Sutton D. Sutton	0	256	1.000	.000	450	435	4.78	1,823	27	0	5	2709.2	2,855	1,440	1,575	324	830	61	10	87	11,709	66	6.05	2.76	2.20	1.08	15.6	7.1	1.36	.292	5.23	9.48
6	Eppa Rixey E. Rixey	0	251	1.000	.000	426	307	4.60	672	76	0	14	2219.0	2,699	1,133	1,442	70	632	40	85		9,766	62	2.73	2.56	1.06	0.28	6.9	6.5	1.50	.315	5.85	10.95
7	Bert Blyleven B. Blyleven	0	250	1.000	.000	405	399	4.83	1,898	75	0	0	2633.1	2,941	1,414	1,558	325	799	97	3	54	11,459	77	6.49	2.73	2.38	1.11	16.6	7.0	1.42	.314	5.32	10.05
8	Robin Roberts R. Roberts	0	245	1.000	.000	390	334	4.91	1,077	67	0	25	2222.1	2,629	1,213	1,354	322	512	28	40	63	9,647	19	4.36	2.07	2.10	1.30	11.2	5.3	1.41	.299	5.48	10.65
9	Warren Spahn W. Spahn	0	245	1.000	.000	387	307	5.19	1,004	60	0	28	2057.0	2,401	1,187	1,330	261	676	24	63	38	9,091	41	4.39	2.96	1.49	1.14	11.0	7.4	1.50	.300	5.82	10.51
10	Steve Carlton S. Carlton	0	244	1.000	.000	412	382	4.91	1,875	38	0	2	2434.1	2,675	1,328	1,528	291	1,044	28	12	120	10,823	91	6.93	3.86	1.80	1.08	17.3	9.6	1.53	.314	5.65	9.89
11	Early Wynn E. Wynn	0	244	1.000	.000	391	324	5.86	978	65	0	15	2023.2	2,455	1,318	1,501	227	941	37	54	32	9,325	29	4.35	4.18	1.04	1.01	10.5	10.1	1.68	.312	6.68	10.92
12	Jim Kaat J. Kaat	0	237	1.000	.000	615	365	4.95	1,189	34	0	17	2332.0	2,816	1,282	1,502	262	700	75	87	93	10,389	76	4.59	2.70	1.70	1.01	11.4	6.7	1.51	.313	5.80	10.87
13	Frank Tanana F. Tanana	0	236	1.000	.000	398	380	5.07	1,485	44	0	1	2318.0	2,623	1,305	1,469	317	807	86	8	96	10,266	74	5.77	3.13	1.84	1.23	14.5	7.9	1.48	.305	5.70	10.18
14	Tommy John T. John	0	231	1.000	.000	472	416	5.01	1,194	33	0	3	2427.1	2,943	1,350	1,542	217	817	56	19	76	10,808	137	4.43	3.03	1.46	0.80	11.0	7.6	1.55	.320	5.72	10.91
15	Bob Friend B. Friend	0	230	1.000	.000	405	311	5.11	896	30	0	10	1984.1	2,442	1,126	1,304	203	566	30	47	90	8,806	38	4.06	2.57	1.58	0.92	10.2	6.4	1.52	.315	5.91	11.08
16	Ted Lyons T. Lyons	0	230	1.000	.000	334	239	5.56	509	120	1	25	1881.1	2,458	1,162	1,413	140	629	21	78		8,632	38	2.43	3.01	0.81	0.67	5.9	7.3	1.64	.316	6.76	11.76
17	Greg Maddux G. Maddux	0	227	1.000	.000	389	385	4.59	1,604	17	0	0	2406.0	2,706	1,227	1,388	228	583	80	3	134	10,383	41	6.00	2.18	2.75	0.85	15.4	5.6	1.37	.314	5.19	10.12
18	Fergie Jenkins F. Jenkins	0	226	1.000	.000	380	316	5.02	1,437	59	0	7	2106.2	2,360	1,176	1,296	307	588	46	33	88	9,163	32	6.14	2.51	2.44	1.31	15.7	6.4	1.40	.303	5.54	10.08
19	Red Ruffing R. Ruffing	0	225	1.000	.000	351	274	5.73	897	107	0	18	1990.0	2,385	1,266	1,482	172	842	40	60		9,086	24	4.06	3.81	1.07	0.78	9.9	9.3	1.62	.310	6.70	10.79
20	Bobo Newsom B. Newsom	0	222	1.000	.000	389	287	5.59	1,044	74	0	21	1975.2	2,389	1,227	1,414	145	1,022	39	59		9,190	32	4.76	4.66	1.02	0.66	11.4	11.1	1.73	.323	6.44	10.88
21	Sad Sam Jones S. Sam Jones	0	217	1.000	.000	418	275	5.68	615	72	0	31	1979.1	2,523	1,249	1,505	107	806	43	100		9,054	50	2.80	3.66	0.76	0.49	6.8	8.9	1.68	.323	6.84	11.47
22	Jack Quinn J. Quinn	0	217	1.000	.000	510	251	3.95	704	77	1	56	2050.1	2,579		1,368	77	530	58	171			43	3.09	2.33	1.33	0.34		6.3	1.52	.355	6.00	11.32
23	Charlie Hough C. Hough	0	216	1.000	.000	642	266	4.81	1,461	35	0	61	2328.2	2,223	1,245	1,420	281	1,180	127	210	36	10,286	126	5.65	4.56	1.24	1.09	14.2	11.5	1.46	.268	5.49	8.59
24	Red Faber R. Faber	0	213	1.000	.000	415	256	4.59	674	71	0	27	1955.2	2,365	998	1,270	70	632	62	112		8,731	30	3.10	2.91	1.07	0.32	7.7	7.2	1.53	.315	5.84	10.88
25	Paul Derringer P. Derringer	0	212	1.000	.000	356	239	5.12	718	67	0	29	1772.2	2,255	1,008	1,198	108	459	21	81		7,970	35	3.65	2.33	1.56	0.55	9.0	5.8	1.53	.322	6.08	11.45