Between the 2000 and 2010 seasons, Roy Halladay won the most games, with 160 wins.

Interpreted as:

most MLB regular-season wins by a player between 2000 to 2010

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Roy Halladay R. Halladay	160	79	.669	308	300	3.29	1,619	56	18	0	2134.0	2,063	780	864	175	404	58	4	22	8,705	42	6.83	1.70	4.01	0.74	18.6	4.6	1.16	.293	3.64	72	3.28	74	8.70	271.4
2	Andy Pettitte A. Pettitte	159	92	.633	324	321	3.86	1,542	11	3	0	2011.0	2,098	862	969	178	586	35	1	32	8,544	33	6.90	2.62	2.63	0.80	18.0	6.9	1.33	.310	4.34	87	3.63	81	9.39	186.8
3	CC Sabathia	157	88	.641	322	322	3.57	1,787	30	11	0	2127.0	1,947	844	919	188	664	66	0	28	8,804	44	7.56	2.81	2.69	0.80	20.3	7.5	1.23	.288	3.89	81	3.57	82	8.24	186.9
4	Tim Hudson T. Hudson	154	85	.644	324	323	3.43	1,409	22	11	0	2152.0	2,026	821	892	176	644	80	0	67	8,944	57	5.89	2.69	2.19	0.74	15.8	7.2	1.24	.279	3.73	78	3.84	88	8.47	132.2
5	Roy Oswalt R. Oswalt	150	83	.644	316	303	3.18	1,666	20	8	0	2015.0	1,918	712	765	173	467	71	5	32	8,292	23	7.44	2.09	3.57	0.77	20.1	5.6	1.18	.295	3.42	75	3.34	77	8.57	225.7
6	Jamie Moyer J. Moyer	149	103	.591	340	334	4.26	1,241	13	4	0	2092.0	2,128	991	1,053	290	570	86	2	31	8,874	21	5.34	2.45	2.18	1.25	14.0	6.4	1.29	.275	4.53	98	4.63	106	9.15	-58.9
7	Mark Buehrle M. Buehrle	148	110	.574	359	334	3.85	1,287	27	8	0	2271.1	2,389	971	1,078	253	519	53	6	36	9,459	20	5.10	2.06	2.48	1.00	13.6	5.5	1.28	.291	4.27	84	4.14	90	9.47	117.1
8	Derek Lowe D. Lowe	146	111	.568	443	303	3.83	1,313	9	3	66	2027.1	2,067	862	973	167	580	58	115	49	8,570	36	5.83	2.57	2.26	0.74	15.3	6.8	1.31	.294	4.32	88	3.79	88	9.18	116
9	Randy Johnson R. Johnson	143	78	.647	287	281	3.34	2,182	32	12	0	1885.1	1,616	699	790	212	484	89	3	22	7,686	34	10.42	2.31	4.51	1.01	28.4	6.3	1.11	.298	3.77	75	3.12	70	7.71	275.2
10	Barry Zito B. Zito	142	120	.542	355	353	3.86	1,651	11	4	0	2198.1	1,959	944	1,026	229	910	88	1	43	9,332	43	6.76	3.73	1.81	0.94	17.7	9.8	1.31	.268	4.20	89	4.28	99	8.02	14.7
11	Livan Hernandez L. Hernandez	139	136	.505	365	365	4.39	1,449	38	8	0	2413.0	2,666	1,177	1,258	266	784	61	0	62	10,429	30	5.40	2.92	1.85	0.99	13.9	7.5	1.43	.305	4.69	103	4.36	101	9.94	-17.4
12	Javier Vazquez J. Vazquez	138	126	.523	359	353	4.07	2,122	23	6	0	2320.1	2,256	1,050	1,121	301	593	71	4	44	9,706	67	8.23	2.30	3.58	1.17	21.9	6.1	1.23	.295	4.35	91	3.79	85	8.75	174.7
13	Greg Maddux G. Maddux	134	101	.570	308	308	3.70	1,211	16	7	0	1939.2	1,965	797	877	196	308	57	0	59	7,964	24	5.62	1.43	3.93	0.91	15.2	3.9	1.17	.286	4.07	86	3.70	85	9.12	147.3
14	Mike Mussina M. Mussina	134	87	.606	283	282	3.87	1,488	18	9	0	1790.2	1,801	769	828	194	364	41	0	14	7,379	35	7.48	1.83	4.09	0.98	20.2	4.9	1.21	.304	4.16	86	3.50	78	9.05	192.8
15	Johan Santana J. Santana	133	69	.658	339	263	3.10	1,877	13	8	1	1908.2	1,609	658	708	203	528	36	23	12	7,763	67	8.85	2.49	3.55	0.96	24.2	6.8	1.12	.275	3.34	71	3.39	79	7.59	189.9
16	Jon Garland J. Garland	131	114	.535	344	321	4.32	1,096	10	6	1	2029.1	2,120	975	1,078	248	680	59	9	36	8,664	46	4.86	3.02	1.61	1.10	12.7	7.8	1.38	.284	4.78	96	4.68	104	9.40	-35.3
17	Kevin Millwood K. Millwood	119	119	.500	338	336	4.27	1,530	16	4	0	2051.1	2,146	973	1,053	231	643	62	0	37	8,824	48	6.71	2.82	2.38	1.01	17.3	7.3	1.36	.301	4.62	97	4.08	92	9.42	77.4
18	Tom Glavine T. Glavine	118	87	.576	283	283	3.77	948	11	7	0	1753.2	1,769	734	790	178	600	30	0	59	7,431	10	4.87	3.08	1.58	0.91	12.8	8.1	1.35	.280	4.05	89	4.39	101	9.08	-6.9
19	Jeff Suppan J. Suppan	118	118	.500	354	336	4.57	1,130	11	4	0	2067.0	2,298	1,050	1,154	273	720	85	10	48	9,060	74	4.92	3.13	1.57	1.19	12.5	7.9	1.46	.296	5.02	103	4.87	110	10.01	-102.6
20	Bartolo Colon B. Colon	117	82	.588	246	245	4.07	1,222	23	5	0	1573.2	1,571	712	777	205	510	31	0	19	6,660	26	6.99	2.92	2.40	1.17	18.3	7.7	1.32	.291	4.44	90	4.22	94	8.98	45
21	Curt Schilling C. Schilling	117	63	.650	243	221	3.54	1,545	26	7	9	1569.1	1,515	618	630	194	257	21	21	9	6,368	23	8.86	1.47	6.01	1.11	24.3	4.0	1.13	.304	3.61	78	3.23	73	8.69	204.8
22	John Lackey J. Lackey	116	82	.586	267	266	3.89	1,357	14	8	0	1716.0	1,752	741	816	169	513	82	0	21	7,301	86	7.12	2.69	2.65	0.89	18.6	7.0	1.32	.306	4.28	88	3.82	88	9.19	99.1
23	Carlos Zambrano C. Zambrano	116	74	.611	295	258	3.50	1,441	9	4	0	1681.0	1,432	653	724	133	767	87	6	36	7,164	56	7.72	4.11	1.88	0.71	20.1	10.7	1.31	.274	3.88	80	3.92	89	7.67	87
24	Freddy Garcia F. Garcia	116	79	.595	270	269	4.13	1,220	10	3	0	1728.1	1,691	794	838	215	521	50	0	31	7,289	68	6.35	2.71	2.34	1.12	16.7	7.1	1.28	.279	4.36	93	4.25	95	8.81	45.6
25	Tim Wakefield T. Wakefield	114	105	.521	378	269	4.40	1,293	7	0	7	1887.0	1,817	923	1,020	243	652	112	40	21	8,087	82	6.17	3.11	1.98	1.16	16.0	8.1	1.31	.272	4.86	95	4.59	106	8.67	-61.9