Between the 1895 and 1904 seasons, Cy Young struck out the most hitters, with 1,370 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Cy Young C. Young	1,370	446	273	138	.664	402	2.61	378	45	7	3665.2	3,618	1,064	1,531	71	463	79	41	14,644	66	3.36	1.14	2.96	0.17	9.4	3.2	1.11	.280	3.76	69	2.90	77	8.88	354.3
2	Rube Waddell R. Waddell	1,212	190	99	74	.572	173	2.29	151	18	1	1536.1	1,316	391	583	27	390	64	16	6,141	40	7.10	2.28	3.11	0.16	19.7	6.4	1.11	.290	3.42	71	2.24	70	7.71	155.9
3	Vic Willis V. Willis	1,012	279	139	118	.541	261	2.76	232	22	5	2233.0	2,046	686	974	44	747	120	17	9,241	61	4.08	3.01	1.35	0.18	11.0	8.1	1.25	.274	3.93	82	3.26	94	8.25	54.5
4	Jack Powell J. Powell	959	327	157	134	.540	302	3.25	268	25	7	2591.0	2,636	936	1,259	86	629	79	25	10,730	46	3.33	2.18	1.52	0.30	8.9	5.9	1.26	.284	4.37	95	3.31	97	9.16	26.5
5	Kid Nichols K. Nichols	953	338	192	117	.621	301	2.78	287	26	13	2731.2	2,614	844	1,235	78	638	61	37	11,181	70	3.14	2.10	1.49	0.26	8.5	5.7	1.19	.268	4.07	70	3.48	86	8.61	188.5
6	Noodles Hahn N. Hahn	883	224	122	89	.578	217	2.51	204	23	0	1910.1	1,793	532	755	27	366	47	6	7,639	28	4.16	1.72	2.41	0.13	11.6	4.8	1.13	.280	3.56	73	2.67	77	8.45	172.7
7	Christy Mathewson C. Mathewson	879	174	97	62	.610	160	2.28	137	20	3	1388.1	1,198	351	537	18	372	41	13	5,599	69	5.70	2.41	2.36	0.12	15.7	6.6	1.13	.275	3.48	75	2.49	81	7.77	90
8	Bill Dinneen B. Dinneen	859	259	123	116	.515	246	3.00	224	14	2	2145.1	2,073	714	996	54	604	56	13	8,843	54	3.60	2.53	1.42	0.23	9.7	6.8	1.25	.278	4.18	87	3.20	94	8.70	48.8
9	Chick Fraser C. Fraser	802	315	132	157	.457	291	3.99	262	14	3	2489.2	2,666	1,105	1,611	55	998	187	24	10,993	116	2.90	3.61	0.80	0.20	7.3	9.1	1.47	.292	5.82	113	3.97	110	9.64	-106.7
10	Bill Donovan B. Donovan	780	176	78	72	.520	152	2.81	140	13	5	1392.2	1,231	435	607	10	552	40	23	5,791	49	5.04	3.57	1.41	0.06	13.5	9.5	1.28	.277	3.92	92	2.96	97	7.96	15
11	Jack Chesbro J. Chesbro	735	217	132	65	.670	191	2.58	173	24	3	1718.0	1,526	493	675	23	414	74	23	6,904	34	3.85	2.17	1.78	0.12	10.6	6.0	1.13	.266	3.54	81	2.88	90	7.99	55.2
12	Clark Griffith C. Griffith	716	329	190	112	.629	309	3.15	286	20	2	2700.2	2,907	946	1,405	50	573	131	20	11,347	46	2.39	1.91	1.25	0.17	6.3	5.0	1.29	.289	4.68	81	3.52	91	9.69	114.3
13	Jesse Tannehill J. Tannehill	688	257	152	84	.644	233	2.71	201	23	5	2029.1	2,075	612	875	19	310	94	23	8,266	16	3.05	1.37	2.22	0.08	8.3	3.8	1.18	.287	3.88	81	2.84	85	9.20	114.1
14	Joe McGinnity J. McGinnity	663	290	169	90	.653	252	2.65	226	19	10	2285.0	2,159	673	979	31	575	136	36	9,438	21	2.61	2.26	1.15	0.12	7.0	6.1	1.20	.265	3.86	76	3.28	95	8.50	46.8
15	Red Donahue R. Donahue	659	317	145	149	.493	294	3.70	272	21	2	2582.2	2,977	1,061	1,464	57	607	98	20	11,055	27	2.30	2.12	1.09	0.20	6.0	5.5	1.39	.303	5.10	101	3.48	98	10.37	9.1
16	Togie Pittinger T. Pittinger	616	180	75	84	.472	162	3.08	141	16	1	1471.2	1,477	503	725	31	545	63	16	6,205	35	3.77	3.33	1.13	0.19	9.9	8.8	1.37	.292	4.43	98	3.37	106	9.03	-28
17	Ned Garvin N. Garvin	612	181	58	97	.374	158	2.72	134	13	3	1400.2	1,320	423	714	20	413	71	23	5,781	48	3.93	2.65	1.48	0.13	10.6	7.1	1.24	.279	4.59	79	3.12	93	8.48	38.6
18	Pink Hawley P. Hawley	612	289	137	121	.531	259	3.79	222	11	2	2226.2	2,444	937	1,321	38	659	158	26	9,654	45	2.47	2.66	0.93	0.15	6.3	6.8	1.39	.294	5.34	95	3.91	97	9.88	25.2
19	Doc McJames D. McJames	593	178	79	80	.497	162	3.43	137	6	4	1361.1	1,414	519	816	19	563	56	15	5,933	79	3.92	3.72	1.05	0.13	10.0	9.5	1.45	.297	5.39	86	3.74	93	9.35	41.8
20	Al Orth A. Orth	593	297	143	122	.540	267	3.65	233	19	6	2319.2	2,590	942	1,267	59	450	65	30	9,729	28	2.30	1.75	1.32	0.23	6.1	4.6	1.31	.296	4.92	103	3.38	95	10.05	44.6
21	Cy Seymour C. Seymour	591	141	61	56	.521	124	3.73	105	6	1	1038.0	954	430	632	25	659	86	15	4,670	60	5.12	5.71	0.90	0.22	12.7	14.1	1.55	.281	5.48	98	4.33	114	8.27	-66.6
22	Eddie Plank E. Plank	574	156	86	61	.585	147	2.73	129	12	0	1254.0	1,201	381	512	15	280	67	7	5,119	31	4.12	2.01	2.05	0.11	11.2	5.5	1.18	.284	3.67	84	2.74	87	8.62	63.3
23	Deacon Phillippe D. Phillippe	573	205	118	70	.628	185	2.63	169	16	6	1624.0	1,596	474	708	30	225	35	20	6,522	24	3.18	1.25	2.55	0.17	8.8	3.4	1.12	.277	3.92	80	2.80	83	8.84	98.4
24	Ed Doheny E. Doheny	572	184	75	83	.475	169	3.73	141	6	2	1405.0	1,421	583	936	13	667	141	15	6,229	87	3.66	4.27	0.86	0.08	9.2	10.7	1.49	.291	6.00	106	3.93	110	9.10	-65.3
25	Frank Kitson F. Kitson	569	224	107	87	.552	195	3.07	170	15	6	1706.0	1,789	582	819	46	351	58	28	7,059	30	3.00	1.85	1.62	0.24	8.1	5.0	1.25	.289	4.32	94	3.18	97	9.44	25.9