Between the 1897 and 1906 seasons, Rube Waddell fanned the most hitters, with 1,695 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Rube Waddell R. Waddell	1,695	279	141	101	.583	241	2.16	200	33	1	2137.2	1,768	512	758	33	572	84	34	8,484	60	7.14	2.41	2.96	0.14	20.0	6.7	1.09	.284	3.19	70	2.17	71	7.44	203.5
2	Cy Young C. Young	1,459	425	241	153	.612	383	2.44	359	40	6	3490.0	3,314	948	1,376	60	381	76	39	13,702	61	3.76	0.98	3.83	0.15	10.6	2.8	1.06	.278	3.55	73	2.54	75	8.55	319.2
3	Vic Willis V. Willis	1,285	361	174	160	.521	338	2.70	300	32	6	2897.0	2,681	870	1,232	51	930	138	22	11,906	81	3.99	2.89	1.38	0.16	10.8	7.8	1.25	.277	3.83	84	3.13	94	8.33	66.7
4	Christy Mathewson C. Mathewson	1,213	255	150	83	.644	232	2.20	191	34	7	1993.2	1,712	487	722	25	513	45	22	7,985	79	5.48	2.32	2.36	0.11	15.2	6.4	1.12	.273	3.26	74	2.40	80	7.73	134.1
5	Jack Powell J. Powell	1,187	395	180	162	.526	354	3.14	309	29	9	3066.0	3,068	1,068	1,449	92	746	94	39	12,627	56	3.48	2.19	1.59	0.27	9.4	5.9	1.24	.283	4.25	94	3.18	97	9.01	38.7
6	Jack Chesbro J. Chesbro	1,043	307	174	97	.642	271	2.59	221	31	4	2346.1	2,102	674	938	30	560	90	32	9,405	48	4.00	2.15	1.86	0.12	11.1	6.0	1.13	.270	3.60	83	2.74	88	8.06	91.5
7	Bill Dinneen B. Dinneen	1,016	318	143	149	.490	302	3.06	269	17	3	2607.2	2,517	886	1,214	65	706	64	15	10,695	61	3.51	2.44	1.44	0.22	9.5	6.6	1.24	.277	4.19	94	3.13	96	8.69	43.5
8	Bill Donovan B. Donovan	1,000	235	105	102	.507	209	2.82	189	18	5	1885.0	1,688	590	810	16	725	58	25	7,821	55	4.77	3.46	1.38	0.08	12.8	9.3	1.28	.278	3.87	96	2.94	100	8.06	3.4
9	Noodles Hahn N. Hahn	917	243	130	94	.580	231	2.55	212	25	0	2029.1	1,916	574	821	27	381	52	11	8,126	28	4.07	1.69	2.41	0.12	11.3	4.7	1.13	.280	3.64	75	2.65	77	8.50	181.2
10	Chick Fraser C. Fraser	899	342	144	171	.457	318	3.68	286	18	2	2710.2	2,811	1,108	1,595	55	1,061	181	24	11,763	109	2.98	3.52	0.85	0.18	7.6	9.0	1.43	.288	5.30	111	3.73	110	9.33	-103.9
11	Joe McGinnity J. McGinnity	893	381	217	117	.650	327	2.63	284	24	15	2945.0	2,764	860	1,237	38	717	157	47	12,093	24	2.73	2.19	1.25	0.12	7.4	5.9	1.18	.265	3.78	79	3.13	94	8.45	64.5
12	Eddie Plank E. Plank	892	223	129	79	.620	213	2.59	185	21	0	1812.1	1,661	521	695	19	406	106	8	7,312	41	4.43	2.02	2.20	0.09	12.2	5.6	1.14	.279	3.45	84	2.61	86	8.25	88.3
13	Jesse Tannehill J. Tannehill	883	321	187	104	.643	291	2.72	246	31	5	2497.1	2,520	756	1,057	35	408	117	29	10,146	24	3.18	1.47	2.16	0.13	8.7	4.0	1.17	.286	3.81	85	2.84	89	9.08	106.7
14	Al Orth A. Orth	799	346	165	144	.534	310	3.34	267	28	5	2679.2	2,833	993	1,326	59	509	68	35	11,023	35	2.68	1.71	1.57	0.20	7.2	4.6	1.25	.289	4.45	100	3.07	93	9.51	72.2
15	Deacon Phillippe D. Phillippe	796	276	153	93	.622	242	2.55	213	24	6	2121.2	2,047	602	881	33	299	47	33	8,474	38	3.38	1.27	2.66	0.14	9.4	3.5	1.11	.276	3.74	80	2.65	81	8.68	138.5
16	Togie Pittinger T. Pittinger	795	246	106	108	.495	215	3.10	179	22	3	1938.2	1,916	668	942	36	699	91	27	8,152	42	3.69	3.25	1.14	0.17	9.8	8.6	1.35	.288	4.37	102	3.29	106	8.89	-39.2
17	Tom Hughes T. Hughes	771	199	75	99	.431	181	3.15	146	15	0	1487.2	1,486	520	733	26	480	54	17	6,239	45	4.66	2.90	1.61	0.16	12.4	7.7	1.32	.297	4.43	108	2.89	101	8.99	-2.3
18	Kid Nichols K. Nichols	770	269	147	99	.598	240	2.72	228	23	9	2170.0	2,003	657	912	51	506	55	28	8,797	56	3.19	2.10	1.52	0.21	8.8	5.8	1.16	.263	3.78	76	3.21	88	8.31	120.1
19	Doc White D. White	761	198	98	80	.551	185	2.17	153	24	1	1550.1	1,341	374	563	19	361	64	13	6,161	38	4.42	2.10	2.11	0.11	12.4	5.9	1.10	.267	3.27	78	2.62	96	7.78	11.6
20	Harry Howell H. Howell	734	246	96	112	.462	212	3.00	191	16	2	1886.1	1,849	628	915	23	509	69	33	7,778	38	3.50	2.43	1.44	0.11	9.4	6.5	1.25	.283	4.37	93	2.95	94	8.82	38.1
21	Red Donahue R. Donahue	714	332	157	150	.511	307	3.38	283	25	2	2686.1	2,984	1,008	1,387	52	585	97	22	11,312	22	2.39	1.96	1.22	0.17	6.3	5.2	1.33	.297	4.65	99	3.26	98	10.00	10.2
22	Frank Kitson F. Kitson	706	287	125	115	.521	243	3.17	206	19	7	2128.2	2,215	749	1,036	51	465	75	40	8,803	37	2.98	1.97	1.52	0.22	8.0	5.3	1.26	.288	4.38	102	3.12	99	9.37	13.1
23	George Mullin G. Mullin	700	205	91	93	.495	191	2.67	168	16	2	1640.2	1,529	487	725	16	578	48	13	6,790	44	3.84	3.17	1.21	0.09	10.3	8.5	1.28	.278	3.98	93	2.95	105	8.39	-24.2
24	Sam Leever S. Leever	698	274	151	78	.659	243	2.56	204	30	7	2070.1	1,910	590	818	23	461	64	28	8,329	42	3.03	2.00	1.51	0.10	8.4	5.5	1.15	.266	3.56	81	2.92	91	8.30	70.2
25	Casey Patten C. Patten	693	229	94	109	.463	205	3.31	185	16	4	1804.0	1,849	664	925	37	487	68	22	7,518	21	3.46	2.43	1.42	0.18	9.2	6.5	1.29	.291	4.61	111	3.02	103	9.22	-13.9