Between the 1901 and 1910 seasons, Rube Waddell struck out the most hitters, with 2,137 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Rube Waddell R. Waddell	2,137	366	178	127	.584	308	2.11	235	47	4	2659.2	2,198	624	923	30	728	93	45	10,499	70	7.23	2.46	2.94	0.10	20.4	6.9	1.10	.289	3.12	76	1.93	71	7.44	236.6
2	Christy Mathewson C. Mathewson	1,968	421	263	118	.690	379	1.94	308	63	16	3259.1	2,690	702	1,020	41	684	49	38	12,772	97	5.43	1.89	2.88	0.11	15.4	5.4	1.04	.264	2.82	69	2.08	72	7.43	287.1
3	Cy Young C. Young	1,508	383	218	137	.614	351	2.05	319	42	9	3186.0	2,763	726	1,044	38	385	69	28	12,194	48	4.26	1.09	3.92	0.11	12.4	3.2	0.99	.267	2.95	73	2.11	75	7.81	248.2
4	Eddie Plank E. Plank	1,465	372	202	131	.607	346	2.38	285	37	3	2916.1	2,578	772	1,044	29	654	148	21	11,627	62	4.52	2.02	2.24	0.09	12.6	5.6	1.11	.273	3.22	83	2.40	86	7.96	127
5	Bill Donovan B. Donovan	1,387	316	170	117	.592	292	2.51	264	34	7	2601.2	2,266	727	989	25	881	75	24	10,586	52	4.80	3.05	1.57	0.09	13.1	8.3	1.21	.273	3.42	91	2.65	97	7.84	34.1
6	Vic Willis V. Willis	1,318	399	187	167	.528	366	2.50	302	42	9	3106.1	2,822	864	1,194	44	841	85	33	12,483	65	3.82	2.44	1.57	0.13	10.6	6.7	1.18	.272	3.46	89	2.69	93	8.18	71.3
7	Doc White D. White	1,216	342	169	128	.569	307	2.24	235	40	3	2551.2	2,241	635	890	28	549	98	31	10,122	54	4.29	1.94	2.21	0.10	12.0	5.4	1.09	.269	3.14	87	2.40	95	7.90	27
8	George Mullin G. Mullin	1,189	368	178	146	.549	330	2.68	285	30	6	2881.1	2,694	857	1,241	26	935	92	36	11,776	71	3.71	2.92	1.27	0.08	10.1	7.9	1.26	.280	3.88	98	2.75	103	8.41	-19
9	Jack Powell J. Powell	1,184	360	150	158	.487	315	2.69	257	32	14	2718.1	2,516	812	1,092	64	589	67	41	10,821	45	3.92	1.95	2.01	0.21	10.9	5.4	1.14	.275	3.62	96	2.64	96	8.33	26.1
10	Jack Chesbro J. Chesbro	1,181	341	177	110	.617	289	2.52	225	32	4	2532.0	2,262	708	984	32	552	90	46	10,048	50	4.20	1.96	2.14	0.11	11.8	5.5	1.11	.272	3.50	88	2.49	88	8.04	112.1
11	Ed Walsh E. Walsh	1,159	279	128	83	.607	211	1.61	171	43	20	2012.0	1,518	359	551	12	373	38	61	7,641	57	5.18	1.67	3.11	0.05	15.2	4.9	0.94	.249	2.46	67	1.79	77	6.79	109.2
12	Tom Hughes T. Hughes	1,103	295	103	134	.435	245	2.97	192	22	9	2074.1	1,998	685	970	31	630	76	44	8,566	66	4.79	2.73	1.75	0.13	12.9	7.4	1.27	.292	4.21	108	2.64	98	8.67	8.6
13	Chief Bender C. Bender	1,090	251	125	76	.622	201	2.32	172	24	8	1799.0	1,491	463	652	21	409	69	47	7,054	45	5.45	2.05	2.67	0.11	15.5	5.8	1.06	.269	3.26	87	2.12	81	7.46	95.4
14	Earl Moore E. Moore	1,018	260	126	102	.553	232	2.52	185	26	2	2010.1	1,755	563	842	34	716	76	20	8,269	62	4.56	3.21	1.42	0.15	12.3	8.7	1.23	.268	3.77	86	2.90	99	7.86	1.7
15	Bob Ewing B. Ewing	986	286	124	117	.515	260	2.44	204	19	4	2275.2	2,066	616	915	29	599	55	26	9,042	45	3.90	2.37	1.65	0.11	10.9	6.6	1.17	.276	3.62	85	2.53	86	8.17	110.2
16	Mordecai Brown M. Brown	942	292	169	79	.681	226	1.66	197	47	26	2123.0	1,699	392	612	19	420	39	63	8,170	40	3.99	1.78	2.24	0.08	11.5	5.1	1.00	.249	2.59	61	2.21	80	7.20	128.1
17	Red Ames R. Ames	938	207	84	61	.579	162	2.42	104	12	7	1377.0	1,143	370	553	14	523	30	33	5,553	87	6.13	3.42	1.79	0.09	16.9	9.4	1.21	.279	3.61	89	2.29	83	7.47	74.4
18	Addie Joss A. Joss	920	286	160	97	.623	260	1.89	234	45	5	2327.0	1,888	488	730	19	364	58	22	8,891	28	3.56	1.41	2.53	0.07	10.3	4.1	0.97	.248	2.82	70	2.25	86	7.30	88.8
19	Orval Overall O. Overall	905	207	104	66	.612	173	2.18	127	29	12	1467.1	1,159	356	487	15	525	44	30	5,849	57	5.55	3.22	1.72	0.09	15.5	9.0	1.15	.262	2.99	79	2.35	84	7.11	71.9
20	Joe McGinnity J. McGinnity	901	373	190	118	.617	303	2.62	244	27	22	2732.0	2,568	795	1,093	44	606	113	59	11,133	22	2.97	2.00	1.49	0.14	8.1	5.4	1.16	.267	3.60	87	2.87	94	8.46	61.8
21	Harry Howell H. Howell	900	289	110	133	.453	245	2.56	214	18	5	2230.0	2,041	634	952	22	561	83	39	8,957	43	3.63	2.26	1.60	0.09	10.0	6.3	1.17	.273	3.84	89	2.64	97	8.24	25.1
22	Bill Dinneen B. Dinneen	846	285	127	127	.500	253	2.78	221	23	7	2244.2	2,065	694	919	55	530	40	28	8,954	38	3.39	2.13	1.60	0.22	9.4	5.9	1.16	.269	3.68	97	2.85	102	8.28	-1.7
23	Frank Smith F. Smith	834	241	109	82	.571	197	2.22	158	25	3	1746.1	1,380	431	580	10	507	38	40	6,820	56	4.30	2.61	1.64	0.05	12.2	7.4	1.08	.252	2.99	92	2.34	100	7.11	-14.5
24	Togie Pittinger T. Pittinger	805	244	113	104	.521	214	2.98	179	23	3	1926.2	1,882	637	888	32	680	88	26	8,057	43	3.76	3.18	1.18	0.15	10.0	8.4	1.33	.287	4.15	101	3.18	106	8.79	-33.7
25	Deacon Phillippe D. Phillippe	783	289	148	79	.652	218	2.44	180	24	11	2001.0	1,908	543	761	24	255	45	61	7,925	35	3.52	1.15	3.07	0.11	9.9	3.2	1.08	.276	3.42	86	2.36	80	8.58	133.1