Between the 2002 and 2011 seasons, Javier Vazquez fanned the most hitters, with 1,880 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Javier Vazquez J. Vazquez	1,880	326	124	117	.515	320	4.11	18	3	0	2071.2	1,990	946	1,016	274	538	65	4	38	8,661	66	8.17	2.34	3.49	1.19	21.7	6.2	1.22	.291	4.41	94	3.85	88	8.65	122.5
2	CC Sabathia	1,846	322	159	91	.636	322	3.44	33	12	0	2184.0	2,028	835	913	186	630	66	0	31	9,026	39	7.61	2.60	2.93	0.77	20.5	7.0	1.22	.292	3.76	79	3.45	79	8.36	215.9
3	Johan Santana J. Santana	1,785	294	130	66	.663	254	2.90	13	8	1	1779.0	1,457	573	619	186	458	31	9	12	7,170	59	9.03	2.32	3.90	0.94	24.9	6.4	1.08	.270	3.13	67	3.26	77	7.37	197.8
4	Roy Halladay R. Halladay	1,699	304	170	75	.694	303	2.97	63	18	0	2194.2	2,067	724	801	168	372	59	0	26	8,857	34	6.97	1.53	4.57	0.69	19.2	4.2	1.11	.290	3.28	67	3.11	71	8.48	302.5
5	Roy Oswalt R. Oswalt	1,615	311	145	90	.617	306	3.25	17	7	0	2012.1	1,945	726	777	170	476	70	1	32	8,311	26	7.22	2.13	3.39	0.76	19.4	5.7	1.20	.297	3.48	77	3.38	78	8.70	207.5
6	Josh Beckett J. Beckett	1,597	275	123	79	.609	272	3.87	10	5	0	1697.2	1,563	730	786	189	512	64	1	18	7,080	52	8.47	2.71	3.12	1.00	22.6	7.2	1.22	.291	4.17	88	3.66	87	8.29	105.3
7	A.J. Burnett	1,573	267	103	90	.534	262	4.09	19	8	0	1663.0	1,524	756	826	172	674	89	1	19	7,100	115	8.51	3.65	2.33	0.93	22.2	9.5	1.32	.294	4.47	96	3.90	90	8.25	80.8
8	Jake Peavy J. Peavy	1,554	251	109	81	.574	250	3.47	9	5	0	1581.1	1,384	610	641	159	499	53	0	37	6,546	32	8.84	2.84	3.11	0.90	23.7	7.6	1.19	.286	3.65	86	3.47	82	7.88	132.6
9	Carlos Zambrano C. Zambrano	1,538	313	124	79	.611	281	3.55	9	4	0	1819.0	1,575	718	791	150	815	91	5	40	7,756	56	7.61	4.03	1.89	0.74	19.8	10.5	1.31	.276	3.91	82	3.95	91	7.79	79.7
10	Ted Lilly T. Lilly	1,481	301	120	103	.538	294	4.02	5	3	0	1758.2	1,600	786	828	258	567	50	1	33	7,393	44	7.58	2.90	2.61	1.32	20.0	7.7	1.23	.266	4.24	92	4.35	101	8.19	-2.3
11	John Lackey J. Lackey	1,465	295	128	94	.577	294	4.10	14	8	0	1876.0	1,955	855	935	189	569	101	0	22	8,044	97	7.03	2.73	2.57	0.91	18.2	7.1	1.35	.309	4.49	94	3.90	91	9.38	85.5
12	Randy Johnson R. Johnson	1,463	217	103	65	.613	212	3.61	21	7	0	1387.0	1,233	557	627	170	337	65	2	19	5,691	21	9.49	2.19	4.34	1.10	25.7	5.9	1.13	.291	4.07	82	3.41	78	8.00	150.3
13	Dan Haren D. Haren	1,443	266	107	84	.560	256	3.59	15	5	0	1700.0	1,631	678	738	191	357	46	3	27	7,014	72	7.64	1.89	4.04	1.01	20.6	5.1	1.17	.289	3.91	84	3.57	83	8.63	133
14	Barry Zito B. Zito	1,400	319	121	112	.519	313	4.02	7	1	0	1945.0	1,762	868	939	215	809	73	4	42	8,279	36	6.48	3.74	1.73	0.99	16.9	9.8	1.32	.268	4.34	94	4.43	103	8.15	-28.7
15	Aaron Harang A. Harang	1,329	268	95	94	.503	262	4.25	13	6	0	1622.1	1,721	767	813	217	465	46	2	36	6,939	55	7.37	2.58	2.86	1.20	19.2	6.7	1.35	.308	4.51	99	4.13	95	9.55	47.2
16	Brett Myers B. Myers	1,326	307	94	85	.525	249	4.24	12	3	21	1623.1	1,631	764	815	229	536	53	40	34	6,938	40	7.35	2.97	2.47	1.27	19.1	7.7	1.33	.292	4.52	101	4.35	102	9.04	-11.1
17	Cliff Lee C. Lee	1,323	254	119	69	.633	250	3.65	26	11	0	1641.2	1,616	665	727	168	392	45	1	12	6,842	35	7.25	2.15	3.38	0.92	19.3	5.7	1.22	.295	3.99	84	3.59	84	8.86	116.3
18	Kevin Millwood K. Millwood	1,314	290	106	102	.510	289	4.21	16	4	0	1772.0	1,870	829	898	194	549	58	0	29	7,628	41	6.67	2.79	2.39	0.99	17.2	7.2	1.37	.304	4.56	95	4.04	92	9.50	68.5
19	Derek Lowe D. Lowe	1,289	336	146	114	.562	334	4.01	9	3	0	2031.1	2,086	905	1,017	168	599	54	1	39	8,617	31	5.71	2.65	2.15	0.74	15.0	7.0	1.32	.295	4.51	94	3.84	91	9.24	91
20	Felix Hernandez F. Hernandez	1,264	205	85	67	.559	205	3.24	18	4	0	1388.1	1,275	500	564	116	424	42	0	14	5,751	72	8.19	2.75	2.98	0.75	22.0	7.4	1.22	.297	3.66	78	3.37	80	8.27	130
21	Andy Pettitte A. Pettitte	1,253	261	125	73	.631	258	3.78	6	2	0	1605.2	1,655	674	755	147	465	25	1	25	6,783	29	7.02	2.61	2.69	0.82	18.5	6.9	1.32	.308	4.23	85	3.63	82	9.28	141.6
22	Livan Hernandez L. Hernandez	1,245	327	117	123	.488	327	4.38	32	7	0	2121.2	2,345	1,032	1,099	236	672	59	0	58	9,142	23	5.28	2.85	1.85	1.00	13.6	7.4	1.42	.304	4.66	104	4.37	103	9.95	-29.2
23	Randy Wolf R. Wolf	1,235	264	100	78	.562	264	3.98	8	7	0	1619.1	1,549	717	766	204	557	72	0	31	6,879	32	6.86	3.10	2.22	1.13	18.0	8.1	1.30	.280	4.26	97	4.34	103	8.61	-21
24	Mark Buehrle M. Buehrle	1,233	330	141	110	.562	330	3.87	23	6	0	2204.0	2,367	948	1,055	245	497	44	0	36	9,207	20	5.03	2.03	2.48	1.00	13.4	5.4	1.30	.295	4.31	85	4.13	90	9.67	107.3
25	Ryan Dempster R. Dempster	1,224	413	75	81	.481	191	4.32	7	1	87	1403.1	1,376	674	733	144	600	53	184	31	6,075	47	7.85	3.85	2.04	0.92	20.1	9.9	1.41	.304	4.70	102	4.04	96	8.82	30.1