Between the 2001 and 2023 seasons, Justin Verlander won the most games, with 257 wins.

Interpreted as:

most pitcher regular-season wins from 2001 to 2023

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Justin Verlander J. Verlander	257	141	.646	509	509	3.24	3,342	26	9	0	3325.1	2,793	1,197	1,298	340	925	109	0	27	13,549	95	9.05	2.50	3.61	0.92	24.7	6.8	1.12	.278	3.51	76	3.38	80	7.56	316.3
2	CC Sabathia	251	161	.609	561	560	3.74	3,093	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
3	Zack Greinke Z. Greinke	225	156	.591	586	541	3.49	2,979	17	5	1	3389.1	3,207	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
4	Max Scherzer M. Scherzer	213	108	.664	457	448	3.15	3,367	12	5	0	2834.2	2,306	991	1,063	328	746	111	2	20	11,452	76	10.69	2.37	4.51	1.04	29.4	6.5	1.08	.287	3.38	75	3.16	76	7.32	310.2
5	Clayton Kershaw C. Kershaw	210	92	.695	425	422	2.48	2,944	25	15	0	2712.2	2,055	747	816	225	669	42	1	27	10,683	101	9.77	2.22	4.40	0.75	27.6	6.3	1.00	.269	2.71	63	2.81	70	6.82	364.8
6	Mark Buehrle M. Buehrle	210	159	.569	490	490	3.81	1,833	33	10	0	3232.0	3,417	1,367	1,515	356	715	76	0	48	13,480	27	5.10	1.99	2.56	0.99	13.6	5.3	1.28	.292	4.22	87	4.10	93	9.52	107.8
7	Jon Lester J. Lester	200	117	.631	452	451	3.66	2,488	15	4	0	2740.0	2,610	1,114	1,215	294	892	90	0	13	11,487	63	8.17	2.93	2.79	0.97	21.7	7.8	1.28	.300	3.99	86	3.77	92	8.57	101.7
8	Adam Wainwright A. Wainwright	200	128	.610	478	411	3.53	2,202	28	11	3	2668.1	2,577	1,047	1,117	233	736	81	13	40	11,116	51	7.43	2.48	2.99	0.79	19.8	6.6	1.24	.298	3.77	88	3.53	87	8.69	152.8
9	Bartolo Colon B. Colon	196	159	.552	453	442	4.13	1,938	28	9	0	2770.2	2,933	1,270	1,379	367	650	47	2	32	11,680	28	6.30	2.11	2.98	1.19	16.6	5.6	1.29	.296	4.48	98	4.15	98	9.53	24.7
10	Tim Hudson T. Hudson	191	125	.604	429	426	3.46	1,779	23	11	0	2788.0	2,667	1,071	1,163	216	773	113	0	77	11,578	71	5.74	2.50	2.30	0.70	15.4	6.7	1.23	.282	3.75	84	3.76	91	8.61	121
11	Roy Halladay R. Halladay	190	91	.676	359	357	3.17	1,978	65	19	0	2518.1	2,374	886	968	201	469	75	0	27	10,217	44	7.07	1.68	4.22	0.72	19.4	4.6	1.13	.290	3.46	73	3.19	74	8.48	317
12	John Lackey J. Lackey	188	147	.561	448	446	3.92	2,294	18	8	0	2840.1	2,862	1,237	1,347	319	815	133	0	32	12,030	125	7.27	2.58	2.81	1.01	19.1	6.8	1.29	.300	4.27	92	3.94	94	9.07	79.6
13	Felix Hernandez F. Hernandez	169	136	.554	419	418	3.42	2,524	25	11	0	2729.2	2,487	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
14	Cole Hamels C. Hamels	163	122	.572	423	422	3.43	2,560	17	7	0	2698.0	2,424	1,027	1,103	310	767	100	0	43	11,115	57	8.54	2.56	3.34	1.03	23.0	6.9	1.18	.287	3.68	82	3.68	88	8.09	151.3
15	Roy Oswalt R. Oswalt	163	102	.615	365	341	3.36	1,852	20	8	0	2245.1	2,199	838	897	197	520	80	7	34	9,301	30	7.42	2.08	3.56	0.79	19.9	5.6	1.21	.301	3.60	79	3.36	78	8.81	236.2
16	Derek Lowe D. Lowe	161	135	.544	450	358	4.09	1,434	10	4	25	2278.2	2,385	1,035	1,157	188	682	64	63	53	9,718	42	5.66	2.69	2.10	0.74	14.8	7.0	1.35	.299	4.57	96	3.87	91	9.42	94.8
17	Barry Zito B. Zito	158	139	.532	419	407	4.09	1,807	11	4	0	2484.0	2,317	1,129	1,224	276	1,019	95	9	50	10,625	48	6.55	3.69	1.77	1.00	17.0	9.6	1.34	.275	4.43	99	4.40	105	8.39	-53.1
18	David Price D. Price	157	82	.657	400	322	3.32	2,076	17	3	3	2143.2	1,930	790	865	221	562	63	19	16	8,807	40	8.72	2.36	3.69	0.93	23.6	6.4	1.16	.290	3.63	81	3.38	83	8.10	165.9
19	A.J. Burnett	157	148	.515	415	410	3.97	2,423	24	10	0	2607.1	2,402	1,150	1,259	252	1,031	141	1	30	11,119	159	8.36	3.56	2.35	0.87	21.8	9.3	1.32	.296	4.35	97	3.82	92	8.29	97.4
20	Andy Pettitte A. Pettitte	156	98	.614	334	331	3.76	1,614	9	2	0	2067.0	2,142	864	969	186	575	35	1	29	8,728	38	7.03	2.50	2.81	0.81	18.5	6.6	1.31	.310	4.22	86	3.57	81	9.33	187.5
21	Dan Haren D. Haren	153	131	.539	391	380	3.75	2,013	16	6	1	2419.2	2,357	1,009	1,105	305	500	67	4	39	10,022	98	7.49	1.86	4.03	1.13	20.1	5.0	1.18	.288	4.11	92	3.77	92	8.77	92.8
22	Jake Peavy J. Peavy	152	126	.547	388	377	3.63	2,207	15	6	0	2377.0	2,134	960	1,011	259	708	78	3	42	9,838	46	8.36	2.68	3.12	0.98	22.4	7.2	1.20	.285	3.83	90	3.64	89	8.08	127.6
23	Ervin Santana E. Santana	151	129	.539	425	386	4.11	1,978	21	11	0	2486.2	2,391	1,135	1,221	331	776	104	20	35	10,482	104	7.16	2.81	2.55	1.20	18.9	7.4	1.27	.282	4.42	99	4.31	104	8.65	-44.1
24	Rick Porcello R. Porcello	150	125	.545	355	351	4.40	1,561	10	3	0	2096.1	2,270	1,025	1,122	260	489	84	2	17	8,912	70	6.70	2.10	3.19	1.12	17.5	5.5	1.32	.308	4.82	102	4.06	97	9.75	26.3
25	Jered Weaver J. Weaver	150	98	.605	331	331	3.63	1,621	14	8	0	2067.1	1,912	833	879	262	551	55	0	17	8,531	37	7.06	2.40	2.94	1.14	19.0	6.5	1.19	.273	3.83	89	4.06	99	8.32	5.6