Between the 2004 and 2023 seasons, Justin Verlander won the most games, with 257 wins.

Interpreted as:

most pitcher regular-season wins from 2004 to 2023

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Justin Verlander J. Verlander	257	141	.646	509	509	3.24	3,342	26	9	0	3325.1	2,793	1,197	1,298	340	925	109	0	27	13,549	95	9.05	2.50	3.61	0.92	24.7	6.8	1.12	.278	3.51	76	3.38	80	7.56	316.3
2	Zack Greinke Z. Greinke	225	156	.591	586	541	3.49	2,979	17	5	1	3389.1	3,207	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
3	Max Scherzer M. Scherzer	213	108	.664	457	448	3.15	3,367	12	5	0	2834.2	2,306	991	1,063	328	746	111	2	20	11,452	76	10.69	2.37	4.51	1.04	29.4	6.5	1.08	.287	3.38	75	3.16	76	7.32	310.2
4	Clayton Kershaw C. Kershaw	210	92	.695	425	422	2.48	2,944	25	15	0	2712.2	2,055	747	816	225	669	42	1	27	10,683	101	9.77	2.22	4.40	0.75	27.6	6.3	1.00	.269	2.71	63	2.81	70	6.82	364.8
5	CC Sabathia	208	136	.605	465	464	3.66	2,632	34	11	0	2989.1	2,867	1,216	1,336	327	850	109	0	38	12,503	57	7.92	2.56	3.10	0.98	21.1	6.8	1.24	.296	4.02	85	3.73	86	8.63	198.3
6	Jon Lester J. Lester	200	117	.631	452	451	3.66	2,488	15	4	0	2740.0	2,610	1,114	1,215	294	892	90	0	13	11,487	63	8.17	2.93	2.79	0.97	21.7	7.8	1.28	.300	3.99	86	3.77	92	8.57	101.7
7	Adam Wainwright A. Wainwright	200	128	.610	478	411	3.53	2,202	28	11	3	2668.1	2,577	1,047	1,117	233	736	81	13	40	11,116	51	7.43	2.48	2.99	0.79	19.8	6.6	1.24	.298	3.77	88	3.53	87	8.69	152.8
8	Felix Hernandez F. Hernandez	169	136	.554	419	418	3.42	2,524	25	11	0	2729.2	2,487	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
9	John Lackey J. Lackey	169	127	.571	397	395	3.87	2,074	15	6	0	2528.0	2,526	1,088	1,178	278	716	119	0	28	10,680	107	7.38	2.55	2.90	0.99	19.4	6.7	1.28	.300	4.19	91	3.88	94	8.99	79.3
10	Cole Hamels C. Hamels	163	122	.572	423	422	3.43	2,560	17	7	0	2698.0	2,424	1,027	1,103	310	767	100	0	43	11,115	57	8.54	2.56	3.34	1.03	23.0	6.9	1.18	.287	3.68	82	3.68	88	8.09	151.3
11	Mark Buehrle M. Buehrle	161	125	.563	389	389	3.84	1,454	22	6	0	2541.1	2,743	1,085	1,200	285	545	60	0	37	10,633	19	5.15	1.93	2.67	1.01	13.7	5.1	1.29	.297	4.25	88	4.12	95	9.71	65.8
12	David Price D. Price	157	82	.657	400	322	3.32	2,076	17	3	3	2143.2	1,930	790	865	221	562	63	19	16	8,807	40	8.72	2.36	3.69	0.93	23.6	6.4	1.16	.290	3.63	81	3.38	83	8.10	165.9
13	Ervin Santana E. Santana	151	129	.539	425	386	4.11	1,978	21	11	0	2486.2	2,391	1,135	1,221	331	776	104	20	35	10,482	104	7.16	2.81	2.55	1.20	18.9	7.4	1.27	.282	4.42	99	4.31	104	8.65	-44.1
14	Rick Porcello R. Porcello	150	125	.545	355	351	4.40	1,561	10	3	0	2096.1	2,270	1,025	1,122	260	489	84	2	17	8,912	70	6.70	2.10	3.19	1.12	17.5	5.5	1.32	.308	4.82	102	4.06	97	9.75	26.3
15	Jered Weaver J. Weaver	150	98	.605	331	331	3.63	1,621	14	8	0	2067.1	1,912	833	879	262	551	55	0	17	8,531	37	7.06	2.40	2.94	1.14	19.0	6.5	1.19	.273	3.83	89	4.06	99	8.32	5.6
16	Dan Haren D. Haren	150	124	.547	377	366	3.71	1,970	16	6	1	2347.0	2,273	968	1,061	296	478	62	4	39	9,702	95	7.55	1.83	4.12	1.14	20.3	4.9	1.17	.287	4.07	91	3.75	92	8.72	95.5
17	Bartolo Colon B. Colon	147	126	.538	352	341	4.29	1,415	10	6	0	2073.0	2,271	989	1,081	291	423	38	2	22	8,783	12	6.14	1.84	3.35	1.26	16.1	4.8	1.30	.299	4.69	103	4.22	101	9.86	-17.4
18	Gerrit Cole G. Cole	145	75	.659	300	300	3.17	2,152	8	5	0	1859.0	1,549	654	702	206	471	55	0	6	7,471	58	10.42	2.28	4.57	1.00	28.8	6.3	1.09	.293	3.40	79	3.13	76	7.50	208
19	James Shields J. Shields	145	139	.511	407	405	4.01	2,234	23	9	0	2616.0	2,581	1,167	1,267	361	746	97	1	22	10,993	107	7.69	2.57	2.99	1.24	20.3	6.8	1.27	.294	4.36	98	4.16	101	8.88	-13.5
20	Johnny Cueto J. Cueto	144	111	.565	368	363	3.50	1,851	18	8	0	2245.0	2,080	874	946	249	634	120	1	21	9,323	36	7.42	2.54	2.92	1.00	19.9	6.8	1.21	.283	3.79	86	3.91	96	8.34	35.8
21	Roy Halladay R. Halladay	144	74	.661	272	271	3.18	1,510	53	15	0	1907.2	1,801	675	723	162	350	58	0	20	7,721	30	7.12	1.65	4.31	0.76	19.6	4.5	1.13	.291	3.41	75	3.26	76	8.50	214.5
22	Tim Hudson T. Hudson	142	100	.587	326	323	3.61	1,284	13	7	0	2074.2	2,017	832	892	162	579	89	0	54	8,648	49	5.57	2.51	2.22	0.70	14.8	6.7	1.25	.284	3.87	89	3.84	95	8.75	49
23	Cliff Lee C. Lee	140	87	.617	317	313	3.52	1,774	29	12	0	2094.0	2,069	820	893	216	436	48	1	10	8,663	38	7.62	1.87	4.07	0.93	20.5	5.0	1.20	.299	3.84	84	3.42	82	8.89	167.8
24	Bronson Arroyo B. Arroyo	139	123	.531	360	354	4.20	1,446	15	6	0	2231.1	2,280	1,041	1,126	324	572	96	1	43	9,421	35	5.83	2.31	2.53	1.31	15.3	6.1	1.28	.280	4.54	99	4.58	108	9.20	-75.1
25	Lance Lynn L. Lynn	136	95	.589	341	317	3.74	1,906	4	2	1	1889.0	1,743	784	852	215	660	85	4	21	8,009	58	9.08	3.14	2.89	1.02	23.8	8.2	1.27	.297	4.06	91	3.79	92	8.30	72.2