Roger Clemens has won the most career games on Wednesdays, with 69 wins.

Interpreted as:

most pitcher regular-season wins on wednesdays

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Roger Clemens R. Clemens	69	19	.784	114	113	2.66	738	17	8	0	794.2	626	235	256	42	249	20	0	10	3,204	25	8.36	2.82	2.96	0.48	23.0	7.8	1.10	.271	2.90	7.09
2	Greg Maddux G. Maddux	66	45	.595	129	129	2.77	579	23	11	0	879.0	783	271	320	64	160	21	0	20	3,530	12	5.93	1.64	3.62	0.66	16.4	4.5	1.07	.266	3.28	8.02
3	Walter Johnson W. Johnson	64	36	.640	115	89	1.82	488	69	20	7	772.0	627		236	13	200	28	26			19	5.69	2.33	2.44	0.15		6.5	1.07	.262	2.75	7.31
4	Gaylord Perry G. Perry	62	42	.596	128	116	2.98	602	57	8	2	916.0	856	303	339	77	236	12	5	30	3,750	31	5.91	2.32	2.55	0.76	16.1	6.3	1.19	.276	3.33	8.41
5	Tom Glavine T. Glavine	61	31	.663	109	109	3.21	431	12	5	0	732.0	666	261	280	55	244	8	0	24	3,032	13	5.30	3.00	1.77	0.68	14.2	8.0	1.24	.266	3.44	8.19
6	Nolan Ryan N. Ryan	58	43	.574	136	127	3.01	920	35	12	1	908.1	641	304	352	52	416	19	3	12	3,732	42	9.12	4.12	2.21	0.52	24.7	11.1	1.16	.253	3.49	6.35
7	Warren Spahn W. Spahn	56	29	.659	106	97	2.56	397	60	12	1	791.2	681	225	261	53	235	7	6		3,216	12	4.51	2.67	1.69	0.60	12.3	7.3	1.16	.249	2.97	7.74
8	Christy Mathewson C. Mathewson	56	21	.727	86	76	1.05	347	64	15	2	671.2	605		224	10	101	7	8			13	4.65	1.35	3.44	0.13		3.8	1.05	.271	3.00	8.11
9	Grover Alexander G. Alexander	55	28	.663	103	84	2.39	327	60	17	6	749.0	685		269	21	149	12	13			11	3.93	1.79	2.19	0.25		4.9	1.11	.263	3.23	8.23
10	Steve Carlton S. Carlton	53	44	.546	124	117	3.07	705	45	14	0	859.0	746	293	333	68	284	11	4	28	3,538	30	7.39	2.98	2.48	0.71	19.9	8.0	1.20	.274	3.49	7.82
11	Phil Niekro P. Niekro	51	42	.548	135	113	3.03	548	46	12	4	865.0	767	291	354	72	266	19	13	8	3,566	37	5.70	2.77	2.06	0.75	15.4	7.5	1.19	.261	3.68	7.98
12	Don Sutton D. Sutton	50	34	.595	118	116	3.11	562	30	10	0	803.2	714	278	309	59	207	14	2	18	3,296	19	6.29	2.32	2.71	0.66	17.1	6.3	1.15	.267	3.46	8.00
13	Tom Seaver T. Seaver	49	33	.598	106	106	3.00	641	35	11	0	791.1	653	264	300	71	227	9	0	25	3,217	12	7.29	2.58	2.82	0.81	19.9	7.1	1.11	.257	3.41	7.43
14	Robin Roberts R. Roberts	49	37	.570	107	98	3.40	418	50	7	2	756.2	736	286	308	83	155	6	8		3,116	4	4.97	1.84	2.70	0.99	13.4	5.0	1.18	.266	3.66	8.75
15	Eddie Plank E. Plank	49	30	.620	92	79	1.19	340	64	11	2	670.1	571		223	5	151	32	13			12	4.56	2.03	2.25	0.07		5.9	1.08	.278	2.99	7.67
16	Bert Blyleven B. Blyleven	46	39	.541	110	110	2.84	665	42	14	0	834.1	738	263	288	61	219	27	0	14	3,405	19	7.17	2.36	3.04	0.66	19.5	6.4	1.15	.278	3.11	7.96
17	Tommy John T. John	46	36	.561	123	110	3.27	359	24	3	0	750.1	773	273	313	43	190	10	5	14	3,109	32	4.31	2.28	1.89	0.52	11.5	6.1	1.28	.291	3.75	9.27
18	Andy Pettitte A. Pettitte	45	22	.672	85	84	3.20	378	5	0	0	545.1	557	194	222	41	153	10	1	2	2,277	11	6.24	2.53	2.47	0.68	16.6	6.7	1.30	.304	3.66	9.19
19	Jack Morris J. Morris	45	28	.616	85	83	3.51	379	32	5	0	634.0	571	247	265	59	202	11	1	18	2,617	30	5.38	2.87	1.88	0.84	14.5	7.7	1.22	.260	3.76	8.11
20	Justin Verlander J. Verlander	42	19	.689	78	78	2.98	551	7	2	0	535.1	392	177	185	54	124	14	0	2	2,094	14	9.26	2.08	4.44	0.91	26.3	5.9	0.96	.250	3.11	6.59
21	Bob Gibson B. Gibson	42	34	.553	95	83	3.04	569	46	9	1	681.2	582	230	263	54	203	11	4	18	2,793	15	7.51	2.68	2.80	0.71	20.4	7.3	1.15	.270	3.47	7.68
22	Randy Johnson R. Johnson	41	30	.577	94	92	2.98	754	15	6	0	637.0	483	211	235	52	224	32	1	6	2,579	18	10.65	3.16	3.37	0.73	29.2	8.7	1.11	.284	3.32	6.82
23	Milt Pappas M. Pappas	41	25	.621	85	78	3.27	270	21	5	2	545.1	525	198	216	48	138	9	6	12	2,253	15	4.46	2.28	1.96	0.79	12.0	6.1	1.22	.267	3.56	8.66
24	Earl Whitehill E. Whitehill	41	29	.586	89	78	4.03	229	43	3	2	625.0	654	280	339	31	240	17	8		2,735	7	3.30	3.46	0.95	0.45	8.4	8.8	1.43	.281	4.88	9.42
25	David Wells D. Wells	40	23	.635	97	78	4.33	394	9	2	1	563.2	595	271	285	66	102	10	7	11	2,347	18	6.29	1.63	3.86	1.05	16.8	4.3	1.24	.298	4.55	9.50