most runs allowed by a pitcher in a single game since 2000

Since 2000, Vin Mazzaro has given up the most runs in a game, with 14 runs against the Cleveland Indians on May 16, 2011.

Interpreted as:

most runs allowed by a pitcher in a single regular-season game since 2000

	NAME	R	DATE	TM		OPP	DEC	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP
1	Vin Mazzaro V. Mazzaro	14	5/16/2011	KCR	vs	CLE		0	54.00	2	0	0	0	2.1	11	14	1	3	0	0	0	21	1
2	Ben Lively B. Lively	13	8/1/2023	CIN	@	CHC	L	1	29.25	2	0	0	0	4.0	13	13	4	2	1	0	0	27	0
3	Jordan Yamamoto J. Yamamoto	13	9/9/2020	MIA	@	ATL		0	40.50	3	0	0	0	2.2	11	12	4	2	0	0	0	22	0
4	Colby Lewis C. Lewis	13	7/10/2014	TEX	vs	LAA	L	1	42.43	1	0	0	0	2.1	13	11	1	0	0	0	0	20	0
5	Scott Kazmir S. Kazmir	13	7/10/2010	LAA	@	OAK	L	1	23.40	2	0	0	0	5.0	11	13	3	3	1	0	1	30	2
6	Jason Marquis J. Marquis	13	6/21/2006	STL	@	CWS	L	1	23.40	3	0	0	0	5.0	14	13	4	1	0	0	0	30	0
7	Jesús Luzardo J. Luzardo	12	5/31/2025	PHI	vs	MIL	L	1	32.40	4	0	0	0	3.1	12	12	2	3	0	0	0	23	0
8	Bradley Blalock B. Blalock	12	5/10/2025	COL	vs	SDP	L	1	29.45	1	0	0	0	3.2	13	12	3	2	0	0	0	26	1
9	Tanner Houck T. Houck	12	4/14/2025	BOS	@	TBR	L	1	42.43	1	0	0	0	2.1	10	11	2	2	0	0	0	20	1
10	Masahiro Tanaka M. Tanaka	12	7/25/2019	NYY	@	BOS	L	1	32.40	4	0	0	0	3.1	12	12	2	3	0	0	0	25	0
11	Edinson Volquez E. Volquez	12	6/24/2016	KCR	vs	HOU	L	1	99.00	0	0	0	0	1.0	8	11	1	3	0	0	0	15	0
12	Hiram Burgos H. Burgos	12	5/11/2013	MIL	@	CIN	L	1	30.00	2	0	0	0	3.0	11	10	1	3	0	0	0	24	0
13	A.J. Burnett	12	5/2/2012	PIT	@	STL	L	1	40.50	2	0	0	0	2.2	12	12	2	1	1	0	0	22	0
14	Jaime Garcia J. Garcia	12	5/28/2011	STL	@	COL	L	1	29.70	6	0	0	0	3.1	11	11	1	4	0	0	0	26	0
15	Randy Wolf R. Wolf	12	7/21/2010	MIL	@	PIT	L	1	19.06	4	0	0	0	5.2	13	12	2	2	0	0	0	31	0
16	Scott Feldman S. Feldman	12	8/12/2008	TEX	@	BOS		1	20.25	2	0	0	0	2.2	10	6	2	3	0	0	0	22	0
17	Jon Garland J. Garland	12	7/6/2007	CWS	vs	MIN	L	1	29.70	0	0	0	0	3.1	11	11	2	3	0	0	1	25	0
18	Jon Garland J. Garland	12	9/25/2006	CWS	@	CLE	L	1	13.50	5	0	0	0	5.1	12	8	0	3	0	0	1	31	0
19	Jason Marquis J. Marquis	12	7/18/2006	STL	vs	ATL	L	1	21.60	4	0	0	0	5.0	14	12	3	2	1	0	0	31	0
20	Dustin McGowan D. McGowan	12	8/21/2005	TOR	@	DET	L	1	20.77	2	0	0	0	4.1	9	10	2	2	3	0	0	28	0
21	Shawn Chacon S. Chacon	12	6/7/2003	COL	vs	KCR	L	1	29.45	2	0	0	0	3.2	9	12	2	6	0	0	0	25	1
22	Wade Miller W. Miller	12	8/23/2000	HOU	vs	CHC	L	1	15.43	0	0	0	0	4.2	12	8	0	2	0	0	0	28	0
23	Jason Johnson J. Johnson	12	8/15/2000	BAL	vs	CWS	L	1	18.00	4	0	0	0	5.0	11	10	2	4	0	0	0	32	0
24	Joe Nathan J. Nathan	12	5/12/2000	SFG	@	COL	L	1	33.75	3	0	0	0	2.2	9	10	2	4	0	0	0	21	0
25	Jose Lima J. Lima	12	4/27/2000	HOU	vs	CHC	L	1	21.60	6	0	0	0	5.0	13	12	5	3	0	0	0	31	1