The Seattle Mariners gave up their most runs in a game against the Red Sox on August 15, 2015, with 22 runs.

Interpreted as:

most runs allowed in a regular-season game by mariners

	TEAM	R	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	IP	H	ER	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Mariners	22	8/15/2015	SEA	@	BOS	L 10-22	22.50	3	0	0	8.0	26	20	4	6	1	0	57	1	3.38	6.75	0.50	4.50	5.3	10.5	4.00	.512	24.75	29.25
2	Mariners	21	9/8/2019	SEA	@	HOU	L 1-21	19.13	8	0	0	8.0	22	17	2	7	1	0	55	0	9.00	7.88	1.14	2.25	14.5	12.7	3.63	.541	23.63	24.75
3	Mariners	20	6/13/2017	SEA	@	MIN	L 7-20	21.38	4	0	0	8.0	28	19	5	2	0	0	51	0	4.50	2.25	2.00	5.63	7.8	3.9	3.75	.575	22.50	31.50
4	Mariners	20	4/17/1993	SEA	@	DET	L 3-20	22.50	7	0	0	8.0	20	20	2	10	1	1	54	1	7.88	11.25	0.70	2.25	13.0	18.5	3.75	.529	22.50	22.50
5	Mariners	19	4/25/2017	SEA	@	DET	L 9-19	21.38	5	0	0	8.0	24	19	4	7	0	1	55	1	5.63	7.88	0.71	4.50	9.1	12.7	3.88	.513	21.38	27.00
6	Mariners	19	8/9/2000	SEA	@	CWS	L 3-19	18.00	4	0	0	8.0	24	16	4	5	0	0	53	3	4.50	5.63	0.80	4.50	7.5	9.4	3.63	.500	21.38	27.00
7	Mariners	19	6/26/1983	SEA	vs	TOR	L 7-19	18.00	6	0	0	9.0	21	18	4	9	1	0	57	1	6.00	9.00	0.67	4.00	10.5	15.8	3.33	.459	19.00	21.00
8	Mariners	18	5/18/2019	SEA	vs	MIN	L 4-18	17.00	5	0	0	9.0	19	17	6	6	0	0	53	0	5.00	6.00	0.83	6.00	9.4	11.3	2.78	.361	18.00	19.00
9	Mariners	18	7/16/2004	SEA	vs	CLE	L 6-18	18.00	5	0	0	9.0	21	18	8	5	3	0	55	0	5.00	5.00	1.00	8.00	9.1	9.1	2.89	.382	18.00	21.00
10	Mariners	18	4/18/2000	SEA	@	CWS	L 11-18	20.25	5	0	0	8.0	19	18	3	8	1	1	51	0	5.63	9.00	0.63	3.38	9.8	15.7	3.38	.471	20.25	21.38
11	Mariners	18	5/21/1997	SEA	@	ANA	L 3-18	18.00	4	0	0	8.0	21	16	3	7	0	0	54	0	4.50	7.88	0.57	3.38	7.4	13.0	3.50	.450	20.25	23.63
12	Mariners	18	4/15/1979	SEA	vs	MIN	L 6-18	11.00	5	0	0	9.0	20	11	3	7	0	0	55	0	5.00	7.00	0.71	3.00	9.1	12.7	3.00	.425	18.00	20.00
13	Mariners	17	7/3/2007	SEA	@	KCR	L 3-17	15.75	4	0	0	8.0	16	14	2	4	3	0	49	1	4.50	4.50	1.00	2.25	8.2	8.2	2.50	.389	19.13	18.00
14	Mariners	17	5/1/1998	SEA	vs	DET	L 3-17	15.00	6	0	0	9.0	20	15	2	2	3	0	51	0	6.00	2.00	3.00	2.00	11.8	3.9	2.44	.474	17.00	20.00
15	Mariners	17	5/3/1997	SEA	vs	MIL	L 4-17	15.00	5	0	0	9.0	17	15	4	6	0	0	49	0	5.00	6.00	0.83	4.00	10.2	12.2	2.56	.382	17.00	17.00
16	Mariners	17	6/13/1994	SEA	@	TEX	L 9-17	19.13	4	0	0	8.0	22	17	5	4	1	0	51	0	4.50	4.50	1.00	5.63	7.8	7.8	3.25	.459	19.13	24.75
17	Mariners	17	9/8/1991	SEA	@	BOS	L 6-17	19.13	5	0	0	8.0	17	17	1	10	1	2	52	0	5.63	11.25	0.50	1.13	9.6	19.2	3.38	.457	19.13	19.13
18	Mariners	17	8/30/1981	SEA	@	CLE	L 11-17	15.75	3	0	0	8.0	16	14	0	6	0	2	48	1	3.38	6.75	0.50	0.00	6.3	12.5	2.75	.410	19.13	18.00
19	Mariners	16	6/3/2023	SEA	@	TEX	L 6-16	18.00	10	0	0	8.0	19	16	4	5	0	0	48	1	11.25	5.63	2.00	4.50	20.8	10.4	3.00	.517	18.00	21.38
20	Mariners	16	5/21/2021	SEA	@	SDP	L 1-16	18.00	8	0	0	8.0	17	16	3	6	0	0	46	0	9.00	6.75	1.33	3.38	17.4	13.0	2.88	.483	18.00	19.13
21	Mariners	16	8/29/2020	SEA	@	LAA	L 3-16	18.00	7	0	0	8.0	13	16	3	11	2	0	49	0	7.88	12.38	0.64	3.38	14.3	22.4	3.00	.385	18.00	14.62
22	Mariners	16	5/20/2017	SEA	vs	CWS	L 1-16	15.00	4	0	0	9.0	19	15	4	2	0	0	47	1	4.00	2.00	2.00	4.00	8.5	4.3	2.33	.405	16.00	19.00
23	Mariners	16	4/9/2013	SEA	vs	HOU	L 9-16	16.00	10	0	0	9.0	22	16	5	6	0	0	53	1	10.00	6.00	1.67	5.00	18.9	11.3	3.11	.531	16.00	22.00
24	Mariners	16	6/22/2007	SEA	vs	CIN	L 1-16	16.00	10	0	0	9.0	16	16	5	6	2	0	52	1	10.00	6.00	1.67	5.00	19.2	11.5	2.44	.379	16.00	16.00
25	Mariners	16	5/8/2003	SEA	vs	NYY	L 5-16	16.00	2	0	0	9.0	17	16	2	3	1	0	48	0	2.00	3.00	0.67	2.00	4.2	6.3	2.22	.375	16.00	17.00