Lefty Weinert has allowed the most runs in a game with exactly 0 hits allowed, with 6 runs against the Brooklyn Robins on June 24, 1923.

Interpreted as:

most runs allowed by a player in a regular-season game with 0 hits

	NAME	R	H	DATE	TM		OPP	DEC	GS	ERA	SO	CG	SHO	SV	IP	ER	HR	BB	HBP	GF	IBB	TBF	WP
1	Lefty Weinert L. Weinert	6	0	6/24/1923	PHN	@	BKN	L	1		0	0	0	0	0.0	4	0	4	1	0		6	0
2	Alex Lange A. Lange	5	0	4/13/2024	DET	vs	MIN	L	0	0.00	2	0	0	0	0.2	0	0	2	0	0	0	6	0
3	Anthony Ranaudo A. Ranaudo	5	0	5/10/2016	TEX	vs	CWS		0	33.75	0	0	0	0	1.1	5	0	5	0	0	0	9	0
4	Dontrelle Willis D. Willis	5	0	6/4/2009	DET	vs	BOS	L	1	19.29	3	0	0	0	2.1	5	0	5	1	0	0	12	0
5	Mark Hutton M. Hutton	5	0	8/20/1996	FLA	@	CHC	L	1		0	0	0	0	0.0	5	0	4	1	0	0	5	0
6	Bryce Florie B. Florie	5	0	4/26/1995	SDP	vs	HOU		0	0.00	0	0	0	0	0.2	0	0	4	0	0	0	7	0
7	Pat Combs P. Combs	5	0	6/26/1991	PHI	@	STL	L	1	135.00	0	0	0	0	0.1	5	0	5	0	0	0	6	0
8	Mitch Williams M. Williams	5	0	5/6/1988	TEX	vs	NYY		0	135.00	1	0	0	0	0.1	5	0	5	0	0	0	6	0
9	Mark Fidrych M. Fidrych	5	0	9/24/1980	DET	vs	TOR		1	67.50	1	0	0	0	0.2	5	0	5	0	0	0	7	0
10	Wayne Twitchell W. Twitchell	5	0	4/20/1979	NYM	@	PHI		0	0.00	1	0	0	0	0.2	0	0	3	1	0	1	8	0
11	Sandy Koufax S. Koufax	5	0	6/3/1958	LAD	vs	CIN	L	1	16.88	3	0	0	0	2.2	5	0	6	0	0	0	13	0
12	Vern Law V. Law	5	0	7/20/1951	PIT	@	BSN	L	1	135.00	0	0	0	0	0.1	5	0	4	1	0	0	6	1
13	Mickey Harris M. Harris	5	0	9/30/1949	WSH	vs	BSA	L	1	27.00	2	0	0	0	1.1	4	0	6	0	0		11	0
14	Roy Parmelee R. Parmelee	5	0	6/14/1933	NYG	vs	BSN		1	135.00	1	0	0	0	0.1	5	0	5	0	0		6	0
15	Hal Carlson H. Carlson	5	0	6/6/1925	PHN	@	PIT	L	1	67.50	0	0	0	0	0.2	5	0	5	0	0		7	0
16	Sherry Smith S. Smith	5	0	9/28/1923	CLE	@	DET	L	1		0	0	0	0	0.0	0	0	2	0	0		5	0
17	Elmer Myers E. Myers	5	0	6/8/1917	PHA	vs	SLA		0	67.50	1	0	0	0	0.2	5	0	6	0	0		7	0
18	Phil Douglas P. Douglas	5	0	6/20/1914	CIN	@	NYG	L	1	0.00	0	0	0	0	1.0	0	0	2	0	0		9	1
19	Pembroke Finlayson P. Finlayson	5	0	6/6/1908	BKN	vs	CIN	L	0		0	0	0	0	0.1		0	4	0	0		5	0
20	José Quijada J. Quijada	4	0	9/28/2024	LAA	vs	TEX	L	0	81.00	1	0	0	0	0.1	3	0	3	1	0	0	5	0
21	Kyle Nicolas K. Nicolas	4	0	5/11/2024	PIT	vs	CHC		0	54.00	2	0	0	0	0.2	4	0	3	1	0	0	6	0
22	James Karinchak J. Karinchak	4	0	9/30/2023	CLE	@	DET		0	0.00	0	0	0	0	0.2	0	0	3	0	0	0	6	0
23	Trevor Stephan T. Stephan	4	0	9/18/2023	CLE	@	KCR	L	0	40.50	0	0	0	0	0.2	3	0	3	1	0	0	6	0
24	Jeurys Familia J. Familia	4	0	4/14/2023	OAK	vs	NYM		0	27.00	2	0	0	0	1.1	4	0	4	0	0	0	8	0
25	Taylor Rogers T. Rogers	4	0	4/12/2023	SFG	vs	LAD	L	0		0	0	0	0	0.0	4	0	4	0	0	0	4	0