Between the 2000 and 2009 seasons, Livan Hernandez gave up the most runs, with 1,165 runs.

Interpreted as:

most runs allowed by a player in the 2000s

	NAME	R	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Livan Hernandez L. Hernandez	1,165	332	129	124	.510	332	4.46	1,335	36	7	0	2201.1	2,450	1,091	250	720	57	0	57	9,533	29	5.46	2.94	1.85	1.02	14.0	7.6	1.44	.307	4.76	104	4.40	102	10.02	-19.5
2	Jeff Suppan J. Suppan	1,093	324	115	110	.511	321	4.55	1,079	11	4	0	1965.2	2,168	993	260	683	83	0	47	8,608	70	4.94	3.13	1.58	1.19	12.5	7.9	1.45	.293	5.00	102	4.87	110	9.93	-92
3	Javier Vazquez J. Vazquez	1,025	328	128	116	.525	327	3.98	2,001	23	6	0	2163.0	2,101	957	269	528	64	0	40	9,023	59	8.33	2.20	3.79	1.12	22.2	5.9	1.22	.297	4.26	89	3.66	82	8.74	195
4	Jon Garland J. Garland	992	311	117	102	.534	288	4.42	960	10	6	1	1829.1	1,944	898	228	593	53	9	27	7,827	40	4.72	2.92	1.62	1.12	12.3	7.6	1.39	.286	4.88	97	4.71	103	9.56	-22.8
5	Jamie Moyer J. Moyer	989	321	140	94	.598	315	4.23	1,178	11	3	0	1980.1	2,025	931	270	550	80	2	31	8,414	21	5.35	2.50	2.14	1.23	14.0	6.5	1.30	.277	4.49	97	4.61	105	9.20	-46.8
6	Mark Buehrle M. Buehrle	973	326	135	97	.582	301	3.80	1,188	24	8	0	2061.0	2,143	871	236	470	52	6	35	8,562	17	5.19	2.05	2.53	1.03	13.9	5.5	1.27	.288	4.25	82	4.16	90	9.36	106
7	Kevin Millwood K. Millwood	937	307	115	103	.528	305	4.18	1,398	15	4	0	1860.2	1,923	865	201	578	56	0	35	7,982	41	6.76	2.80	2.42	0.97	17.5	7.2	1.34	.300	4.53	94	4.00	90	9.30	87.6
8	Barry Zito B. Zito	929	321	133	106	.556	320	3.84	1,501	10	4	0	1999.0	1,775	852	209	826	81	0	36	8,484	36	6.76	3.72	1.82	0.94	17.7	9.7	1.30	.267	4.18	88	4.29	98	7.99	23.4
9	Tim Wakefield T. Wakefield	928	346	110	95	.537	250	4.33	1,209	7	0	7	1747.0	1,664	840	224	616	107	30	18	7,477	71	6.23	3.17	1.96	1.15	16.2	8.2	1.31	.271	4.78	93	4.60	106	8.57	-55.8
10	Andy Pettitte A. Pettitte	917	303	148	89	.624	300	3.90	1,441	11	3	0	1882.0	1,975	815	165	545	32	1	29	8,008	31	6.89	2.61	2.64	0.79	18.0	6.8	1.34	.311	4.39	87	3.61	81	9.44	179.8
11	Jeff Weaver J. Weaver	889	282	90	106	.459	245	4.58	1,074	16	7	2	1630.0	1,773	830	195	440	106	11	37	7,056	37	5.93	2.43	2.44	1.08	15.2	6.2	1.36	.301	4.91	105	4.31	98	9.79	12.1
12	Derek Lowe D. Lowe	885	410	130	99	.568	270	3.81	1,177	9	3	66	1833.2	1,863	776	149	519	54	115	39	7,746	32	5.78	2.55	2.27	0.73	15.2	6.7	1.30	.293	4.34	86	3.79	87	9.14	114.6
13	Greg Maddux G. Maddux	877	308	134	101	.570	308	3.70	1,211	16	7	0	1939.2	1,965	797	196	308	57	0	59	7,964	24	5.62	1.43	3.93	0.91	15.2	3.9	1.17	.286	4.07	86	3.70	85	9.12	147.3
14	Kenny Rogers K. Rogers	877	260	105	78	.574	257	4.51	854	7	3	0	1601.1	1,771	802	173	524	72	1	16	6,962	28	4.80	2.95	1.63	0.97	12.3	7.5	1.43	.299	4.93	96	4.52	100	9.95	4.9
15	Sidney Ponson S. Ponson	851	235	71	92	.436	226	5.05	834	23	4	0	1415.1	1,620	794	169	487	41	2	15	6,191	45	5.30	3.10	1.71	1.07	13.5	7.9	1.49	.311	5.41	114	4.55	101	10.30	-5.9
16	Doug Davis D. Davis	837	287	90	97	.481	269	4.26	1,206	7	3	0	1629.0	1,687	771	169	736	39	4	26	7,162	60	6.66	4.07	1.64	0.93	16.8	10.3	1.49	.303	4.62	94	4.38	98	9.32	19.5
17	Mike Mussina M. Mussina	828	283	134	87	.606	282	3.87	1,488	18	9	0	1790.2	1,801	769	194	364	41	0	14	7,379	35	7.48	1.83	4.09	0.98	20.2	4.9	1.21	.304	4.16	86	3.50	78	9.05	192.8
18	CC Sabathia	827	288	136	81	.627	288	3.62	1,590	28	11	0	1889.1	1,738	760	168	590	59	0	22	7,834	36	7.57	2.81	2.69	0.80	20.3	7.5	1.23	.289	3.94	82	3.58	82	8.28	166.2
19	Jarrod Washburn J. Washburn	824	281	97	101	.490	279	4.03	1,016	9	4	1	1728.0	1,724	774	223	516	61	1	20	7,308	28	5.29	2.69	1.97	1.16	13.9	7.1	1.30	.273	4.29	92	4.58	104	8.98	-38.7
20	Kyle Lohse K. Lohse	821	274	84	90	.483	250	4.68	930	7	5	0	1481.2	1,638	770	191	450	62	10	25	6,433	47	5.65	2.73	2.07	1.16	14.5	7.0	1.41	.301	4.99	105	4.53	105	9.95	-34
21	Tim Hudson T. Hudson	818	290	137	76	.643	289	3.50	1,270	21	11	0	1923.1	1,837	749	156	570	71	0	59	8,024	52	5.94	2.67	2.23	0.73	15.8	7.1	1.25	.282	3.83	79	3.81	86	8.60	135.6
22	Jason Marquis J. Marquis	809	290	94	83	.531	231	4.48	867	6	3	1	1485.0	1,528	739	182	578	66	26	33	6,465	43	5.25	3.50	1.50	1.10	13.4	8.9	1.42	.282	4.90	103	4.81	110	9.26	-75.2
23	Miguel Batista M. Batista	806	414	84	91	.480	201	4.54	907	8	3	38	1441.2	1,507	727	150	637	53	111	31	6,353	79	5.66	3.98	1.42	0.94	14.3	10.0	1.49	.295	5.03	100	4.61	103	9.41	-22.7
24	Brad Penny B. Penny	806	279	105	84	.556	275	4.14	1,141	4	2	0	1633.2	1,669	752	159	526	44	1	34	6,930	40	6.29	2.90	2.17	0.88	16.5	7.6	1.34	.298	4.44	98	4.00	93	9.19	57
25	Tom Glavine T. Glavine	790	283	118	87	.576	283	3.77	948	11	7	0	1753.2	1,769	734	178	600	30	0	59	7,431	10	4.87	3.08	1.58	0.91	12.8	8.1	1.35	.280	4.05	89	4.39	101	9.08	-6.9