The St. Louis Cardinals had the most runs by a team in a game in 1918, with 22 runs versus the Brooklyn Robins on July 27, 1918.

Interpreted as:

most runs by a team in a regular-season game in 1918

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Cardinals	22	7/27/1918	SLN	@	BKN	W 22-7	51	26	2	4	3	22	4	0	5	1	57	45	9	2	.510	.545	.882	1.428
2	White Sox	19	5/3/1918	CWS	@	DET	W 19-3	47	25	3	3	0	19	6	0	1	5	56	34	6	3	.532	.585	.723	1.308
3	Pirates	17	7/6/1918	PIT	vs	BSN	W 17-1	42	21	5	2	0	16	4	1	3	5	49	30	7	2	.500	.553	.714	1.267
4	Cardinals	16	8/3/1918	SLN	@	PHN	W 16-12	43	16	4	0	0	11	5	2	2	1	51	20	4	1	.372	.460	.465	.925
5	Athletics	16	7/8/1918	PHA	vs	DET	W 16-9	45	19	2	0	0	14	6	0	5	2	52	21	2	1	.422	.490	.467	.957
6	Braves	16	5/7/1918	BSN	vs	BKN	W 16-0	37	17	1	3	0	14	8	0	1	4	48	24	4	3	.459	.556	.649	1.204
7	Pirates	15	6/23/1918	PIT	@	CIN	W 15-1	46	19	2	1	0	12	4	0	1	3	51	23	3	1	.413	.460	.500	.960
8	Giants	15	4/30/1918	NYG	@	PHN	W 15-0	44	19	4	0	0	13	2	0	1	2	51	23	4	5	.432	.457	.523	.979
9	Reds	14	7/27/1918	CIN	@	PHN	W 14-5	42	20	2	2	0	11	5	0	3	8	50	26	4	3	.476	.532	.619	1.151
10	Cubs	14	6/25/1918	CHC	vs	SLN	W 14-0	35	12	3	1	1	11	6	0	2	4	41	20	5	0	.343	.439	.571	1.010
11	Indians	14	6/7/1918	CLE	vs	BSA	W 14-7	31	13	3	1	0	10	11	0	2	7	45	18	4	3	.419	.571	.581	1.152
12	Senators	14	5/8/1918	WSH	vs	BSA	W 14-4	38	17	0	0	0	12	5	0	2	6	43	17	0	0	.447	.512	.447	.959
13	Braves	14	4/17/1918	BSN	@	PHN	W 14-2	45	17	4	0	0	13	5	0	7	1	51	21	4	1	.378	.440	.467	.907
14	Indians	13	6/29/1918	CLE	vs	DET	W 13-4	34	16	2	1	0	10	4	0	4	2	41	20	3	3	.471	.526	.588	1.115
15	Red Sox	13	6/21/1918	BSA	vs	PHA	W 13-0	37	16	4	2	0	11	3	0	1	0	43	24	6	3	.432	.475	.649	1.124
16	White Sox	13	4/30/1918	CWS	@	CLE	W 13-3	43	17	4	2	0	10	6	0	7	1	51	25	6	2	.395	.469	.581	1.051
17	Red Sox	12	8/30/1918	BSA	vs	PHA	W 12-0	35	11	1	0	0	9	5	2	2	1	43	12	1	1	.314	.429	.343	.771
18	Senators	12	8/26/1918	WSH	vs	CWS	W 12-2	39	17	2	2	0	12	0	0	3	1	40	23	4	1	.436	.436	.590	1.026
19	Indians	12	8/16/1918	CLE	@	NYY	W 12-4	42	17	2	0	0	8	6	0	2	5	48	19	2	0	.405	.479	.452	.932
20	Pirates	12	8/12/1918	PIT	@	CHC	W 12-1	40	17	3	2	0	10	6	0	1	5	49	24	5	3	.425	.500	.600	1.100
21	Phillies	12	8/3/1918	PHN	vs	SLN	L 12-16	41	17	4	1	1	12	3	0	3	0	44	26	6	0	.415	.455	.634	1.089
22	Braves	12	7/26/1918	BSN	vs	CIN	W 12-3	39	19	1	3	0		1	0	7	1	43	26	4	3	.487	.500	.667	1.167
23	Cubs	12	7/25/1918	CHC	@	PHN	W 12-6	35	12	3	0	1	11	11	0	2	3	51	18	4	5	.343	.500	.514	1.014
24	Tigers	12	7/16/1918	DET	@	NYY	W 12-1	39	16	4	2	0	12	5	0	2	0	45	24	6	1	.410	.477	.615	1.093
25	Cardinals	12	6/21/1918	SLN	vs	CIN	W 12-6	41	20	5	1	2		1	0	4	1	45	33	8	3	.488	.500	.805	1.305