The New York Giants had the most runs by an NL team in a loss in 1921, with 10 runs versus the Cubs on June 17, 1921.

Interpreted as:

most runs by an nl team in a regular-season loss in 1921

	TEAM	R	L	DATE	TM		OPP	RESULT	W	L%	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Giants	10	1	6/17/1921	NYG	@	CHC	L 10-11	0	1.000	40	13	3	0	0	8	6	0	3	1	0	46	16	3	0	.325	.413	.400	.813
2	Giants	9	1	10/1/1921	NYG	@	PHN	L 9-10	0	1.000	38	14	1	0	0	7	2	0	3	0	1	42	15	1	2	.368	.400	.395	.795
3	Cubs	9	1	8/12/1921	CHC	@	PIT	L 9-12	0	1.000	40	13	0	0	0	9	0	1	0	0	0	42	13	0	1	.325	.341	.325	.666
4	Phillies	9	1	7/2/1921	PHN	vs	BKN	L 9-11	0	1.000	40	15	4	0	2	9	5	0	5	2	1	45	25	6	0	.375	.444	.625	1.069
5	Cubs	9	1	6/12/1921	CHC	vs	BSN	L 9-12	0	1.000	47	22	3	0	1	8	2	0	4	0	1	50	28	4	1	.468	.490	.596	1.086
6	Phillies	9	1	6/4/1921	PHN	@	SLN	L 9-11	0	1.000	40	16	5	0	0	9	4	0	5	0	1	44	21	5	0	.400	.455	.525	.980
7	Phillies	8	1	8/30/1921	PHN	vs	SLN	L 8-9	0	1.000	37	13	2	0	2	7	4	0	2	0	0	43	21	4	2	.351	.415	.568	.982
8	Braves	8	1	8/22/1921	BSN	vs	PIT	L 8-10	0	1.000	39	13	0	0	0	6	3	1	7	0	1	45	13	0	2	.333	.395	.333	.729
9	Cubs	8	1	8/18/1921	CHC	@	BSN	L 8-9	0	1.000	32	14	3	3	0	8	2	0	0	0	0	35	23	6	1	.438	.471	.719	1.189
10	Pirates	8	1	7/26/1921	PIT	vs	NYG	L 8-9	0	1.000	39	13	1	4	1	8	4	0	2	0	2	45	25	6	2	.333	.395	.641	1.036
11	Cardinals	8	1	7/18/1921	SLN	@	BSN	L 8-14	0	1.000	38	13	0	1	2	8	2	0	3	1	1	41	21	3	1	.342	.375	.553	.928
12	Pirates	8	1	7/11/1921	PIT	@	BKN	L 8-9	0	1.000	38	15	1	2	0	8	2	0	2	0	0	42	20	3	2	.395	.425	.526	.951
13	Cardinals	8	1	7/11/1921	SLN	@	PHN	L 8-9	0	1.000	33	11	3	0	0	7	4	0	2	1	0	39	14	3	2	.333	.405	.424	.830
14	Giants	8	1	6/27/1921	NYG	@	PHN	L 8-12	0	1.000	39	13	6	0	2	7	0	0	0	0	0	40	25	8	1	.333	.333	.641	.974
15	Cubs	8	1	6/8/1921	CHC	vs	PHN	L 8-11	0	1.000	44	17	2	1	0	7	0	0	3	0	0	44	21	3	0	.386	.386	.477	.864
16	Braves	8	1	5/27/1921	BSN	vs	NYG	L 8-9	0	1.000	38	16	0	2	0	7	4	0	7	0	1	43	20	2	1	.421	.476	.526	1.003
17	Phillies	8	1	5/11/1921	PHN	vs	CHC	L 8-19	0	1.000	36	10	1	1	2	7	1	0	4	0	0	38	19	4	1	.278	.297	.528	.825
18	Phillies	8	1	4/13/1921	PHN	vs	NYG	L 8-10	0	1.000	48	18	5	0	0	7	3	0	3	1	1	52	23	5	1	.375	.412	.479	.891
19	Braves	7	1	9/25/1921	BSN	@	CHC	L 7-8	0	1.000	43	10	1	0	1	5	5	1	7	0	2	51	14	2	2	.233	.327	.326	.652
20	Cubs	7	1	9/21/1921	CHC	vs	NYG	L 7-9	0	1.000	38	14	1	0	0	7	7	0	6	1	0	45	15	1	0	.368	.467	.395	.861
21	Braves	7	1	9/20/1921	BSN	@	SLN	L 7-9	0	1.000	37	13	1	2	1	7	2	0	7	0	1	40	21	4	1	.351	.385	.568	.952
22	Cardinals	7	1	9/14/1921	SLN	vs	BKN	L 7-9	0	1.000	40	13	3	0	0	7	4	0	2	0	0	45	16	3	1	.325	.386	.400	.786
23	Cubs	7	1	8/29/1921	CHC	@	NYG	L 7-8	0	1.000	31	12	0	0	1	7	0	1	2	0	2	36	15	1	4	.387	.406	.484	.890
24	Giants	7	1	8/23/1921	NYG	vs	SLN	L 7-10	0	1.000	37	13	2	0	2	7	3	1	4	0	1	42	21	4	1	.351	.415	.568	.982
25	Giants	7	1	8/9/1921	NYG	@	CHC	L 7-8	0	1.000	41	12	1	0	3	5	4	1	0	0	0	46	22	4	0	.293	.370	.537	.906