Between the 1883 and 2006 seasons, Rickey Henderson had the most runs, with 2,295 runs.

Interpreted as:

most runs by a player from 1883 to 2006

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Rickey Henderson R. Henderson	2,295	3,081	10,961	3,055	510	66	297	1,115	2,190	98	1,694	1,406	335	13,346	4,588	873	30	67	61	172	.279	.401	.419	.820	2074	509.6	.372	132	507.9
2	Ty Cobb T. Cobb	2,244	3,034	11,434	4,189	724	295	117	1,933	1,249	94	681	897		13,068	5,854	1,136	291				.366	.433	.512	.945	2534	1,093.6	.445	165	975.1
3	Hank Aaron H. Aaron	2,174	3,298	12,364	3,771	624	98	755	2,297	1,402	32	1,383	240	73	13,940	6,856	1,477	21	121	293	328	.305	.374	.555	.928	2453	936.4	.403	153	858.5
4	Babe Ruth B. Ruth	2,174	2,503	8,399	2,873	506	136	714	2,214	2,062	43	1,330	123		10,617	5,793	1,356	113				.342	.474	.690	1.164	2727	1,436.8	.513	197	1,369.6
5	Pete Rose P. Rose	2,165	3,562	14,053	4,256	746	135	160	1,314	1,566	107	1,143	198	149	15,861	5,752	1,041	56	79	167	247	.303	.375	.409	.784	2190	480.1	.354	121	368.7
6	Barry Bonds B. Bonds	2,152	2,860	9,507	2,841	587	77	734	1,930	2,426	103	1,485	509	141	12,129	5,784	1,398	4	89	645	152	.299	.443	.608	1.051	2565	1,104.6	.435	173	1,106.3
7	Willie Mays W. Mays	2,062	2,992	10,881	3,283	523	140	660	1,903	1,464	44	1,526	338	103	12,493	6,066	1,323	13	91	192	251	.302	.384	.557	.941	2266	894.8	.409	154	802.7
8	Stan Musial S. Musial	1,949	3,026	10,972	3,630	725	177	475	1,951	1,599	53	696	78	31	12,712	6,134	1,377	35	53	127	243	.331	.417	.559	.976	2474	1,032.5	.435	158	896.7
9	Lou Gehrig L. Gehrig	1,888	2,164	8,001	2,721	534	163	493	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.447	.632	1.080	2265	1,046.8	.477	173	980
10	Tristram Speaker T. Speaker	1,882	2,789	10,195	3,514	792	222	117	1,531	1,381	103	394	436		11,988	5,101	1,131	309				.345	.428	.500	.928	2264	921	.436	157	812.3
11	Mel Ott M. Ott	1,859	2,730	9,456	2,876	488	72	511	1,860	1,708	64	896	89		11,337	5,041	1,071	109			38	.304	.414	.533	.947	2204	826.4	.430	156	794.2
12	Frank Robinson F. Robinson	1,829	2,808	10,006	2,943	528	72	586	1,812	1,420	198	1,532	204	77	11,743	5,373	1,186	17	102	218	270	.294	.389	.537	.926	2083	807.2	.404	153	717.1
13	Eddie Collins E. Collins	1,821	2,826	9,949	3,315	438	187	47	1,300	1,499	77	468	741		12,037	4,268	672	512				.333	.424	.429	.853	2032	693.4	.409	144	619.7
14	Carl Yastrzemski C. Yastrzemski	1,816	3,308	11,988	3,419	646	59	452	1,844	1,845	40	1,393	168	116	13,991	5,539	1,157	13	105	190	323	.285	.379	.462	.841	2155	643.2	.375	130	469.8
15	Ted Williams T. Williams	1,798	2,292	7,706	2,654	525	71	521	1,839	2,021	39	709	24	4	9,791	4,884	1,117	5	20	86	197	.344	.482	.634	1.116	2349	1,219.7	.493	188	1,067
16	Paul Molitor P. Molitor	1,782	2,683	10,835	3,319	605	114	234	1,307	1,094	47	1,244	504	131	12,160	4,854	953	75	109	100	209	.306	.369	.448	.817	1785	375.3	.361	122	319.5
17	Craig Biggio C. Biggio	1,776	2,709	10,359	2,930	637	52	281	1,125	1,137	282	1,641	410	121	11,948	4,514	970	94	76	68	145	.283	.367	.436	.803	1718	267.7	.355	117	260.5
18	Charlie Gehringer C. Gehringer	1,775	2,323	8,860	2,839	574	146	184	1,427	1,186	50	372	181		10,237	4,257	904	141			27	.320	.404	.480	.884	1797	516.6	.405	124	350
19	Jimmie Foxx J. Foxx	1,751	2,317	8,134	2,646	458	125	534	1,922	1,452	13	1,311	87		9,670	4,956	1,117	71			69	.325	.428	.609	1.038	2135	934.1	.460	158	780.8
20	Honus Wagner H. Wagner	1,739	2,794	10,439	3,420	643	252	101	1,732	963	125	735	723		11,748	4,870	996	221				.328	.391	.467	.858	2044	725.8	.408	147	650
21	Jesse Burkett J. Burkett	1,720	2,067	8,426	2,850	320	182	75	952	1,029	75	561	389		9,620	3,759	577	90				.338	.415	.446	.861	1921	592.9	.411	137	526.7
22	Willie Keeler W. Keeler	1,719	2,123	8,591	2,932	241	145	33	810	524	129	136	495		9,610	3,562	419	366				.341	.388	.415	.802	1640	406.6	.383	124	330.8
23	Billy Hamilton B. Hamilton	1,697	1,594	6,283	2,164	242	95	40	742	1,189	89	271	914		7,608	2,716	377	47				.344	.455	.432	.888	1716	578.6	.433	142	505.5
24	Mickey Mantle M. Mantle	1,676	2,401	8,102	2,415	344	72	536	1,509	1,733	13	1,710	153	38	9,909	4,511	952	14	47	126	113	.298	.421	.557	.977	1941	840	.428	170	821.8
25	Dave Winfield D. Winfield	1,669	2,973	11,003	3,110	540	88	465	1,833	1,216	25	1,686	223	96	12,358	5,221	1,093	19	95	172	319	.283	.353	.475	.827	1811	416.2	.364	128	400.6