The St. Louis Cardinals put up their most runs in a game versus the Phillies on July 6, 1929, with 28 runs.

Interpreted as:

most runs in a regular-season game by cardinals

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	28	7/6/1929	SLN	@	PHN	W 28-6	53	28	4	1	2	25	9	1	1	0	0	65	40	7	2				.528	.603	.755	1.358
2	Cardinals	23	9/16/1926	SLN	@	PHN	W 23-3	49	22	5	0	0	18	8	0	5	5	0	57	27	5	0				.449	.526	.551	1.077
3	Browns	23	6/1/1895	STL	@	NYG	W 23-2
4	Browns	23	5/26/1895	STL	vs	WSH	W 23-7
5	Cardinals	22	7/27/1918	SLN	@	BKN	W 22-7	51	26	2	4	3	22	4	0	5	1		57	45	9	2				.510	.545	.882	1.428
6	Cardinals	21	4/27/1977	STL	@	CHC	W 21-3	48	19	6	0	1	18	8	1	7	0	0	57	28	7	0	0	3	0	.396	.491	.583	1.075
7	Cardinals	21	8/2/1948	SLN	@	NYG	W 21-5	48	20	8	0	4	20	10	1	0	0	0	59	40	12	0			0	.417	.525	.833	1.359
8	Cardinals	20	7/24/1937	SLN	@	BKN	W 20-2	46	18	2	1	1	19	7	0	2	0	0	54	25	4	1			1	.391	.472	.543	1.015
9	Cardinals	20	4/18/1925	SLN	@	CHC	W 20-5	48	22	7	1	5	18	9	0	3	1	0	58	46	13	1				.458	.544	.958	1.502
10	Cardinals	20	4/16/1912	SLN	vs	CHC	W 20-5	34	16	1	0	1	17	8	1	5	4		47	20	2	4				.471	.581	.588	1.170
11	Cardinals	20	8/5/1901	STL	@	PIT	W 20-6	53	21	3	3	0	15	1	1	3	0	-9	56	30	6	1		-9	-9	.396	.418	.566	.984
12	Browns	20	7/28/1896	STL	vs	LOU	W 20-5
13	Browns	20	7/25/1895	STL	vs	BKN	W 20-3
14	Browns	20	7/15/1892	STL	@	BSN	W 20-3
15	Cardinals	19	5/20/2000	STL	@	PIT	W 19-4	46	19	2	1	3	16	6	2	7	1	0	55	32	6	0	1	0	1	.413	.491	.696	1.187
16	Cardinals	19	9/30/1965	STL	@	HOU	W 19-8	45	19	2	1	1	19	7	0	4	1	0	54	26	4	0	2	0	0	.422	.481	.578	1.059
17	Cardinals	19	7/4/1945	SLN	@	NYG	W 19-2	44	20	1	1	2	18	7	1	4	0	0	53	29	4	1			0	.455	.538	.659	1.198
18	Cardinals	19	9/23/1930	SLN	@	PHN	W 19-16	49	26	7	0	0	18	5	0	5	1	0	54	33	7	0				.531	.574	.673	1.248
19	Cardinals	19	5/15/1922	SLN	vs	PHN	W 19-7	46	23	4	4	1	18	3	1	2	1	0	51	38	9	1				.500	.540	.826	1.366
20	Cardinals	19	7/3/1904	SLN	@	CHC	W 19-2	49	20	3	2	1		3	0	3	2		52	30	6	0				.408	.442	.612	1.055
21	Cardinals	18	5/15/2023	STL	vs	MIL	W 18-1	38	16	2	0	4	18	8	1	7	0	0	48	30	6	0	1	0	1	.421	.521	.789	1.310
22	Cardinals	18	5/22/2022	STL	@	PIT	W 18-4	47	20	5	0	3	18	4	0	4	1	0	52	34	8	0	1	0	0	.426	.462	.723	1.185
23	Cardinals	18	7/20/2018	STL	@	CHC	W 18-5	41	18	5	0	5	18	8	0	2	0	0	52	38	10	2	1	0	1	.439	.520	.927	1.447
24	Cardinals	18	8/22/2008	STL	vs	ATL	W 18-3	44	26	5	0	0	18	9	0	6	0	2	55	31	5	1	1	2	1	.591	.648	.705	1.353
25	Cardinals	18	7/19/1950	SLN	vs	NYG	W 18-4	40	17	2	0	4	17	4	1	1	0	0	45	31	6	0		0	1	.425	.489	.775	1.264