Since 1900, the Chicago Cubs have scored their most runs in a game on August 18, 1995 and on August 25, 1922, with 26 runs.

Interpreted as:

most runs in a regular-season game by cubs since 1900

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	26	8/18/1995	CHC	@	COL	W 26-7	54	27	7	1	3	26	6	0	8	0	0	60	45	11	0	0	0	1	.500	.550	.833	1.383
2	Cubs	26	8/25/1922	CHC	vs	PHN	W 26-23	46	25	8	0	3	24	10	1	4	1	0	59	42	11	2				.543	.632	.913	1.545
3	Cubs	24	7/3/1945	CHC	@	BSN	W 24-2	53	28	7	0	1	22	8	1	0	0	0	62	38	8	0			0	.528	.597	.717	1.314
4	Cubs	23	5/17/1977	CHC	vs	SDP	W 23-6	50	24	4	0	7	22	5	1	0	0	0	57	49	11	1	0	0	1	.480	.536	.980	1.516
5	Cubs	23	4/17/1954	CHC	vs	STL	W 23-13	44	20	7	0	2	21	12	0	1	0	0	57	33	9	0	1	1	2	.455	.561	.750	1.311
6	Cubs	22	6/3/1987	CHC	vs	HOU	W 22-7	44	21	3	0	6	21	9	0	6	1	0	54	42	9	0	1	0	1	.477	.556	.955	1.510
7	Cubs	22	5/17/1979	CHC	vs	PHI	L 22-23	56	26	3	1	6	22	3	0	4	0	0	59	49	10	0	0	0	2	.464	.492	.875	1.367
8	Cubs	22	8/13/1937	CHC	vs	CIN	W 22-6	46	21	0	2	0	17	9	0	4	0	0	55	25	2	0			0	.457	.545	.543	1.089
9	Cubs	21	4/23/2022	CHC	vs	PIT	W 21-0	48	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
10	Cubs	21	5/5/1938	CHC	vs	PHN	W 21-2	40	18	3	3	2	20	13	0	2	0	0	53	33	8	0			2	.450	.585	.825	1.410
11	Cubs	21	6/23/1930	CHC	vs	PHN	W 21-8	47	24	3	2	1	20	4	0	5	2	0	51	34	6	0				.511	.549	.723	1.272
12	Cubs	20	8/1/2023	CHC	vs	CIN	W 20-9	43	21	4	0	7	19	4	1	6	3	0	49	46	11	0	1	0	1	.488	.531	1.070	1.600
13	Cubs	20	5/5/2001	CHC	vs	LAD	W 20-1	39	18	2	0	3	17	9	0	13	0	1	50	29	5	2	0	0	2	.462	.563	.744	1.306
14	Cubs	20	5/20/1967	CHC	vs	LAD	W 20-3	38	14	3	0	3	19	6	2	3	1	0	48	26	6	0	2	0	0	.368	.458	.684	1.143
15	Cubs	20	8/13/1959	CHC	vs	SFG	W 20-9	41	19	2	2	5	20	13	1	2	0	0	56	40	9	1	0	4	0	.463	.600	.976	1.576
16	Cubs	20	8/15/1945	CHC	@	BKN	W 20-6	43	19	3	0	4	20	9	0	2	3	0	53	34	7	1			2	.442	.538	.791	1.329
17	Cubs	20	6/11/1911	CHC	vs	BSN	W 20-2	32	14	4	1	2	19	9	2	6	2		47	26	7	4				.438	.581	.813	1.394
18	Cubs	19	4/30/2008	CHC	vs	MIL	W 19-5	42	17	5	0	2	19	9	0	9	1	0	51	28	7	0	0	0	0	.405	.510	.667	1.176
19	Cubs	19	9/21/1974	CHC	@	STL	W 19-4	43	18	1	0	2	17	9	1	2	0	1	55	25	3	0	2	0	0	.419	.509	.581	1.090
20	Cubs	19	5/13/1969	CHC	vs	SDP	W 19-0	39	15	3	2	4	17	12	1	7	0	0	53	34	9	1	0	0	1	.385	.538	.872	1.410
21	Cubs	19	5/18/1946	CHC	@	NYG	W 19-3	44	18	6	0	2	16	9	1	5	2	0	54	30	8	0			3	.409	.519	.682	1.200
22	Cubs	19	8/21/1935	CHC	@	PHN	W 19-5	48	19	4	0	0	19	8	0	3	0	0	56	23	4	0			0	.396	.482	.479	.961
23	Cubs	19	9/6/1930	CHC	@	PIT	W 19-14	42	17	0	3	1	17	6	0	2	0	0	52	26	4	4				.405	.479	.619	1.098
24	Cubs	19	7/24/1930	CHC	@	PHN	W 19-15	42	17	2	0	0	18	9	0	1	0	0	52	19	2	1				.405	.510	.452	.962
25	Cubs	19	8/25/1925	CHC	@	PHN	W 19-10	48	22	5	0	1	19	5	1	6	3	0	54	30	6	0				.458	.519	.625	1.144