The Pittsburgh Pirates put up the most runs by a team in a loss in 2025, with 16 runs against the Rockies on August 1.

Interpreted as:

most runs in a regular-season loss this season

	TEAM	R	L	DATE	TM		OPP	RESULT	W	L%	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Pirates	16	1	8/1/2025	PIT	@	COL	L 16-17	0	1.000	43	18	2	0	2	16	9	1	9	0	0	53	26	4	0	0	0	2	.419	.528	.605	1.133
2	Yankees	12	1	8/1/2025	NYY	@	MIA	L 12-13	0	1.000	42	15	1	0	3	12	2	0	9	5	0	44	25	4	0	0	0	0	.357	.386	.595	.982
3	Diamondbacks	12	1	5/17/2025	AZ	vs	COL	L 12-14	0	1.000	43	15	5	1	2	10	4	1	7	2	0	49	28	8	0	1	0	0	.349	.408	.651	1.059
4	Reds	11	1	7/31/2025	CIN	vs	ATL	L 11-12	0	1.000	47	17	2	0	3	11	4	0	8	0	0	51	28	5	0	0	0	0	.362	.412	.596	1.008
5	Diamondbacks	11	1	5/9/2025	AZ	vs	LAD	L 11-14	0	1.000	38	11	2	0	5	11	6	1	6	0	0	45	28	7	0	0	1	0	.289	.400	.737	1.137
6	Rockies	11	1	4/19/2025	COL	vs	WSH	L 11-12	0	1.000	35	8	0	3	1	11	6	2	17	1	0	44	17	4	0	1	0	0	.229	.364	.486	.849
7	Diamondbacks	11	1	4/18/2025	AZ	@	CHC	L 11-13	0	1.000	43	15	4	0	2	11	3	0	9	0	0	46	25	6	0	0	0	0	.349	.391	.581	.973
8	White Sox	10	1	8/19/2025	CWS	@	ATL	L 10-11	0	1.000	36	11	3	0	1	10	3	0	6	0	0	40	17	4	1	0	0	0	.306	.359	.472	.831
9	Rays	10	1	6/7/2025	TBR	vs	MIA	L 10-11	0	1.000	39	9	3	0	5	10	2	1	8	0	0	43	27	8	1	0	0	0	.231	.286	.692	.978
10	Braves	10	1	6/5/2025	ATL	vs	AZ	L 10-11	0	1.000	37	13	5	0	3	10	4	0	9	0	1	41	27	8	0	0	0	2	.351	.415	.730	1.144
11	Dodgers	10	1	4/22/2025	LAD	@	CHC	L 10-11	0	1.000	39	10	3	0	3	10	4	0	10	0	0	44	22	6	0	1	0	1	.256	.318	.564	.882
12	Marlins	10	1	4/19/2025	MIA	@	PHI	L 10-11	0	1.000	42	15	4	0	2	10	3	1	2	0	0	46	25	6	0	0	0	1	.357	.413	.595	1.008
13	Nationals	9	1	9/26/2025	WSH	vs	CWS	L 9-10	0	1.000	38	13	1	0	6	9	1	0	11	0	0	39	32	7	0	0	0	2	.342	.359	.842	1.201
14	Twins	9	1	9/16/2025	MIN	vs	NYY	L 9-10	0	1.000	35	9	2	0	3	8	5	0	10	4	0	41	20	5	0	1	0	0	.257	.341	.571	.913
15	Reds	9	1	9/3/2025	CIN	vs	TOR	L 9-13	0	1.000	37	10	4	0	0	9	3	0	11	0	0	40	14	4	0	0	0	1	.270	.325	.378	.703
16	Reds	9	1	9/2/2025	CIN	vs	TOR	L 9-12	0	1.000	42	15	5	0	2	8	2	0	9	0	0	44	26	7	0	0	0	1	.357	.386	.619	1.005
17	Marlins	9	1	8/29/2025	MIA	@	NYM	L 9-19	0	1.000	43	15	3	1	2	8	1	0	10	0	0	45	26	6	0	1	0	0	.349	.356	.605	.960
18	Braves	9	1	8/18/2025	ATL	vs	CWS	L 9-13	0	1.000	42	15	1	0	3	9	3	1	9	1	0	46	25	4	0	0	0	1	.357	.413	.595	1.008
19	Nationals	9	1	8/17/2025	WSH	vs	PHI	L 9-11	0	1.000	40	13	5	0	1	9	2	0	9	2	0	42	21	6	0	0	0	0	.325	.357	.525	.882
20	Mets	9	1	8/15/2025	NYM	vs	SEA	L 9-11	0	1.000	39	12	3	0	4	9	1	0	12	1	0	40	27	7	0	0	0	0	.308	.325	.692	1.017
21	Nationals	9	1	8/1/2025	WSH	vs	MIL	L 9-16	0	1.000	41	15	3	1	1	9	4	1	6	0	0	46	23	5	0	0	0	1	.366	.435	.561	.996
22	Rays	9	1	7/23/2025	TBR	vs	CWS	L 9-11	0	1.000	39	15	3	0	2	8	5	2	13	3	0	46	24	5	0	0	0	2	.385	.478	.615	1.094
23	Braves	9	1	7/19/2025	ATL	vs	NYY	L 9-12	0	1.000	36	10	2	0	2	9	8	1	10	1	0	45	18	4	0	0	0	1	.278	.422	.500	.922
24	Yankees	9	1	7/2/2025	NYY	@	TOR	L 9-11	0	1.000	41	15	4	0	2	9	5	0	7	1	0	46	25	6	0	0	1	1	.366	.435	.610	1.045
25	Angels	9	1	6/27/2025	LAA	vs	WSH	L 9-15	0	1.000	37	11	3	0	3	8	6	0	7	0	0	43	23	6	0	0	0	2	.297	.395	.622	1.017