The Detroit Tigers put up the most runs by a team in a loss in 1921, with 15 runs against the White Sox on September 9, 1921.

Interpreted as:

most runs in a regular-season loss in 1921

	TEAM	R	L	DATE	TM		OPP	RESULT	W	L%	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Tigers	15	1	9/9/1921	DET	@	CWS	L 15-20	0	1.000	45	20	1	1	0	13	6	0	2	2	0	53	23	2	2	.444	.510	.511	1.021
2	Red Sox	11	1	8/24/1921	BSA	@	SLA	L 11-12	0	1.000	46	19	3	3	0	9	3	0	2	1	0	50	28	6	1	.413	.449	.609	1.058
3	Senators	11	1	5/16/1921	WSH	@	DET	L 11-17	0	1.000	40	15	5	4	0	10	3	0	1	0	0	45	28	9	2	.375	.419	.700	1.119
4	Browns	10	1	9/4/1921	SLA	@	CWS	L 10-11	0	1.000	38	14	1	0	0	8	5	0	3	0	0	47	15	1	4	.368	.442	.395	.837
5	Athletics	10	1	9/3/1921	PHA	@	BSA	L 10-11	0	1.000	37	12	3	0	1	9	4	1	2	0	0	42	18	4	0	.324	.405	.486	.891
6	White Sox	10	1	7/4/1921	CWS	@	CLE	L 10-11	0	1.000	39	12	2	0	0	9	2	0	2	0	0	43	14	2	2	.308	.341	.359	.700
7	Giants	10	1	6/17/1921	NYG	@	CHC	L 10-11	0	1.000	40	13	3	0	0	8	6	0	3	1	0	46	16	3	0	.325	.413	.400	.813
8	Senators	10	1	5/15/1921	WSH	@	DET	L 10-13	0	1.000	42	16	7	0	0	10	2	0	3	1	0	45	23	7	1	.381	.409	.548	.957
9	Tigers	10	1	5/12/1921	DET	vs	NYY	L 10-11	0	1.000	40	16	3	3	0	10	4	1	3	1	0	45	25	6	0	.400	.467	.625	1.092
10	Giants	9	1	10/1/1921	NYG	@	PHN	L 9-10	0	1.000	38	14	1	0	0	7	2	0	3	0	1	42	15	1	2	.368	.400	.395	.795
11	Senators	9	1	8/31/1921	WSH	vs	NYY	L 9-17	0	1.000	36	14	0	2	1	8	4	3	10	1	1	44	21	3	1	.389	.488	.583	1.072
12	Yankees	9	1	8/19/1921	NYY	@	CWS	L 9-13	0	1.000	39	15	2	4	0	9	6	0	2	1	0	46	25	6	1	.385	.467	.641	1.108
13	Cubs	9	1	8/12/1921	CHC	@	PIT	L 9-12	0	1.000	40	13	0	0	0	9	0	1	0	0	0	42	13	0	1	.325	.341	.325	.666
14	Browns	9	1	8/6/1921	SLA	@	PHA	L 9-12	0	1.000	39	13	3	2	2	7	1	0	3	1	0	41	26	7	1	.333	.350	.667	1.017
15	Red Sox	9	1	7/20/1921	BSA	@	SLA	L 9-10	0	1.000	43	10	3	0	0	8	5	0	6	2	1	50	13	3	2	.233	.313	.302	.615
16	White Sox	9	1	7/13/1921	CWS	vs	WSH	L 9-10	0	1.000	42	15	2	0	0	7	2	1	3	0	1	46	17	2	1	.357	.400	.405	.805
17	Yankees	9	1	7/9/1921	NYY	@	CWS	L 9-10	0	1.000	62	19	3	0	0	9	4	3	7	0	0	72	22	3	3	.306	.377	.355	.732
18	Phillies	9	1	7/2/1921	PHN	vs	BKN	L 9-11	0	1.000	40	15	4	0	2	9	5	0	5	2	1	45	25	6	0	.375	.444	.625	1.069
19	Athletics	9	1	6/14/1921	PHA	vs	SLA	L 9-10	0	1.000	46	14	2	0	4	9	6	0	4	0	0	52	28	6	0	.304	.385	.609	.993
20	Cubs	9	1	6/12/1921	CHC	vs	BSN	L 9-12	0	1.000	47	22	3	0	1	8	2	0	4	0	1	50	28	4	1	.468	.490	.596	1.086
21	Phillies	9	1	6/4/1921	PHN	@	SLN	L 9-11	0	1.000	40	16	5	0	0	9	4	0	5	0	1	44	21	5	0	.400	.455	.525	.980
22	Tigers	9	1	6/3/1921	DET	@	PHA	L 9-15	0	1.000	45	18	2	0	1	8	3	0	2	0	0	48	23	3	0	.400	.438	.511	.949
23	Browns	9	1	5/29/1921	SLA	vs	CLE	L 9-11	0	1.000	44	18	1	0	2	8	0	0	0	0	0	46	25	3	2	.409	.409	.568	.977
24	Browns	9	1	4/14/1921	SLA	vs	CLE	L 9-12	0	1.000	40	15	2	1	0	6	6	0	2	0	1	46	19	3	0	.375	.457	.475	.932
25	Red Sox	8	1	9/22/1921	BSA	vs	CLE	L 8-9	0	1.000	42	12	1	1	0	6	3	1	6	0	0	54	15	2	8	.286	.348	.357	.705