The Philadelphia Phillies had the most runs by a team in a loss in 1922, with 23 runs against the Cubs on August 25, 1922.

Interpreted as:

most runs in a regular-season loss in 1922

	TEAM	R	L	DATE	TM		OPP	RESULT	W	L%	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Phillies	23	1	8/25/1922	PHN	@	CHC	L 23-26	0	1.000	52	26	4	2	0	19	11	0	5	1	1	66	34	6	3	.500	.587	.654	1.241
2	Pirates	14	1	6/21/1922	PIT	@	BKN	L 14-15	0	1.000	53	25	3	2	1	13	3	0	2	0	0	57	35	6	1	.472	.500	.660	1.160
3	Cardinals	11	1	8/29/1922	SLN	vs	CHC	L 11-15	0	1.000	41	16	6	0	0	10	2	0	2	0	1	43	22	6	0	.390	.419	.537	.955
4	Cardinals	11	1	8/24/1922	SLN	vs	BSN	L 11-12	0	1.000	37	11	4	0	1	8	7	0	4	0	0	45	18	5	1	.297	.409	.486	.896
5	Cubs	11	1	8/18/1922	CHC	vs	NYG	L 11-17	0	1.000	47	20	4	0	0	9	2	0	5	0	0	52	24	4	3	.426	.449	.511	.960
6	Red Sox	11	1	8/15/1922	BSA	vs	CWS	L 11-19	0	1.000	43	18	2	1	0	10	3	0	3	1	1	46	22	3	0	.419	.457	.512	.968
7	Phillies	11	1	7/25/1922	PHN	vs	CIN	L 11-15	0	1.000	42	13	6	0	1	11	3	1	8	0	0	47	22	7	1	.310	.370	.524	.893
8	Reds	10	1	9/9/1922	CIN	vs	SLN	L 10-12	0	1.000	42	16	2	0	0	10	2	1	1	0	0	47	18	2	2	.381	.422	.429	.851
9	Phillies	10	1	8/7/1922	PHN	vs	PIT	L 10-17	0	1.000	42	15	5	0	3	9	4	0	9	0	0	47	29	8	1	.357	.413	.690	1.104
10	Robins	10	1	4/15/1922	BKN	@	NYG	L 10-17	0	1.000	35	8	0	0	0	8	5	0	3	0	0	42	8	0	2	.229	.325	.229	.554
11	Cardinals	9	1	9/15/1922	SLN	@	PHN	L 9-10	0	1.000	35	14	0	0	2	8	5	0	5	0	1	43	20	2	3	.400	.475	.571	1.046
12	Indians	9	1	9/5/1922	CLE	@	SLA	L 9-10	0	1.000	40	14	2	0	0	9	6	1	5	0	0	48	16	2	1	.350	.447	.400	.847
13	Indians	9	1	8/16/1922	CLE	@	PHA	L 9-10	0	1.000	36	12	4	0	0	9	4	0	4	0	2	41	16	4	1	.333	.400	.444	.844
14	Indians	9	1	8/3/1922	CLE	vs	NYY	L 9-10	0	1.000	43	16	1	0	1	9	3	0	1	0	0	47	20	2	1	.372	.413	.465	.878
15	Senators	9	1	7/7/1922	WSH	vs	DET	L 9-11	0	1.000	35	14	5	2	0	8	2	1	3	2	1	40	23	7	2	.400	.447	.657	1.105
16	Cardinals	9	1	7/4/1922	SLN	vs	CIN	L 9-11	0	1.000	41	13	3	0	0	8	2	0	2	0	0	44	16	3	1	.317	.349	.390	.739
17	Cardinals	9	1	6/24/1922	SLN	vs	CHC	L 9-10	0	1.000	37	13	4	0	4	9	5	0	1	0	0	44	29	8	2	.351	.429	.784	1.212
18	Braves	9	1	6/23/1922	BSN	@	PHN	L 9-10	0	1.000	43	14	1	1	1	9	4	0	4	0	0	47	20	3	0	.326	.383	.465	.848
19	Red Sox	9	1	6/19/1922	BSA	@	DET	L 9-11	0	1.000	35	12	1	0	1	8	8	0	4	0	0	46	16	2	3	.343	.465	.457	.922
20	Cubs	9	1	5/11/1922	CHC	vs	PHN	L 9-11	0	1.000	39	11	4	1	0	9	3	0	2	0	1	44	17	5	2	.282	.333	.436	.769
21	Red Sox	9	1	5/10/1922	BSA	vs	DET	L 9-10	0	1.000	43	14	4	1	0	5	6	0	4	1	0	50	20	5	1	.326	.408	.465	.873
22	Indians	9	1	4/30/1922	CLE	@	SLA	L 9-11	0	1.000	36	14	2	0	0	9	4	2	3	0	1	43	16	2	1	.389	.476	.444	.921
23	Athletics	9	1	4/17/1922	PHA	@	WSH	L 9-11	0	1.000	39	14	0	3	0	7	4	1	6	0	0	45	20	3	1	.359	.432	.513	.945
24	Cubs	8	1	9/30/1922	CHC	vs	SLN	L 8-9	0	1.000	39	15	3	0	0	7	2	1	3	1	1	42	18	3	0	.385	.429	.462	.890
25	Phillies	8	1	9/26/1922	PHN	vs	CIN	L 8-15	0	1.000	40	14	2	0	4	8	2	0	3	0	0	43	28	6	1	.350	.381	.700	1.081