Since 1940, Chubby Dean has allowed the most runs in a game, with 16 runs against the Red Sox on September 28, 1940.

Interpreted as:

most runs surrendered by a player regular-season game since 1940

	NAME	R	DATE	TM		OPP	DEC	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP
1	Chubby Dean C. Dean	16	9/28/1940	PHA	@	BSA	L	1	15.75	1	1	0	0	8.0	19	14	1	5	0	0		47	2
2	Tommy Warren T. Warren	15	4/30/1944	BKN	@	NYG		0	19.80	2	0	0	0	5.0	13	11	2	6	0	1		35	1
3	Vin Mazzaro V. Mazzaro	14	5/16/2011	KCR	vs	CLE		0	54.00	2	0	0	0	2.1	11	14	1	3	0	0	0	21	1
4	Mike Oquist M. Oquist	14	8/3/1998	OAK	vs	NYY	L	1	25.20	3	0	0	0	5.0	16	14	4	3	0	0	0	32	0
5	Bill Travers B. Travers	14	8/14/1977	MIL	@	CLE	L	1	16.43	4	0	0	0	7.2	18	14	2	4	1	0	0	45	2
6	Al Jurisich A. Jurisich	14	6/28/1947	PHN	@	NYG	L	1	15.75	1	1	0	0	8.0	16	14	3	6	0	0		46	0
7	Luke Hamlin L. Hamlin	14	9/4/1944	PHA	@	NYY	L	1	14.63	4	1	0	0	8.0	19	13	4	1	0	0		41	0
8	Les McCrabb L. McCrabb	14	4/16/1942	PHA	@	BSA		0	31.50	0	0	0	0	4.0	14	14	2	2	1	1		29	1
9	George Caster G. Caster	14	9/18/1940	PHA	@	DET	L	1	13.50	3	1	0	0	8.0	17	12	2	4	0	0		46	0
10	Carl Doyle C. Doyle	14	6/8/1940	BKN	@	CIN		0	31.50	2	0	0	0	4.0	16	14	1	4	4	0		36	2
11	Ben Lively B. Lively	13	8/1/2023	CIN	@	CHC	L	1	29.25	2	0	0	0	4.0	13	13	4	2	1	0	0	27	0
12	Jordan Yamamoto J. Yamamoto	13	9/9/2020	MIA	@	ATL		0	40.50	3	0	0	0	2.2	11	12	4	2	0	0	0	22	0
13	Colby Lewis C. Lewis	13	7/10/2014	TEX	vs	LAA	L	1	42.43	1	0	0	0	2.1	13	11	1	0	0	0	0	20	0
14	Scott Kazmir S. Kazmir	13	7/10/2010	LAA	@	OAK	L	1	23.40	2	0	0	0	5.0	11	13	3	3	1	0	1	30	2
15	Jason Marquis J. Marquis	13	6/21/2006	STL	@	CWS	L	1	23.40	3	0	0	0	5.0	14	13	4	1	0	0	0	30	0
16	Mike Busby M. Busby	13	4/7/1996	STL	@	ATL	L	1	18.00	4	0	0	0	4.0	9	8	4	4	1	0	0	28	0
17	David Wells D. Wells	13	8/20/1992	TOR	@	MIL	L	1	27.00	1	0	0	0	4.1	11	13	1	4	2	0	0	29	0
18	Galen Cisco G. Cisco	13	7/27/1962	BOS	@	WSH	L	1	18.56	2	0	0	0	5.1	16	11	2	4	0	0	0	36	0
19	Karl Drews K. Drews	13	8/18/1949	SLA	vs	CLE	L	1	21.60	2	0	0	0	5.0	13	12	2	2	0	0		30	0
20	Bobo Newsom B. Newsom	13	6/24/1945	PHA	@	NYY	L	1	13.50	4	1	0	0	8.0	15	12	3	4	0	0		43	0
21	Chubby Dean C. Dean	13	9/19/1940	PHA	@	DET	L	1	12.38	1	1	0	0	8.0	14	11	2	4	0	0		42	0
22	Hugh Casey H. Casey	13	5/7/1940	BKN	@	SLN	L	1	16.71	1	0	0	0	7.0	15	13	5	0	3	0		39	1
23	Tanner Houck T. Houck	12	4/14/2025	BOS	@	TBR	L	1	42.43	1	0	0	0	2.1	10	11	2	2	0	0	0	20	1
24	Masahiro Tanaka M. Tanaka	12	7/25/2019	NYY	@	BOS	L	1	32.40	4	0	0	0	3.1	12	12	2	3	0	0	0	25	0
25	Edinson Volquez E. Volquez	12	6/24/2016	KCR	vs	HOU	L	1	99.00	0	0	0	0	1.0	8	11	1	3	0	0	0	15	0