The New York Yankees had their most runs in a game against the Tampa Bay Devil Rays on July 22, 2007, with 21 runs.

Interpreted as:

most runs in a regular-season game yankees scored vs rays

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	21	7/22/2007	NYY	vs	TBD	W 21-4	48	25	4	1	6	20	7	1	8	3	0	56	49	11	0	0	0	1	.521	.589	1.021	1.610
2	Yankees	20	6/21/2005	NYY	vs	TBD	W 20-11	46	23	4	1	6	20	4	0	5	0	0	51	47	11	0	1	1	0	.500	.529	1.022	1.551
3	Yankees	19	4/18/2005	NYY	vs	TBD	W 19-8	45	20	4	0	3	19	7	2	3	0	0	54	33	7	0	0	1	0	.444	.537	.733	1.270
4	Yankees	17	7/21/2007	NYY	vs	TBD	W 17-5	41	20	8	0	2	17	3	0	3	1	0	47	34	10	2	1	0	1	.488	.511	.829	1.340
5	Yankees	17	9/13/2005	NYY	@	TBD	W 17-3	45	20	1	0	1	17	9	0	4	0	0	54	24	2	0	0	0	1	.444	.537	.533	1.070
6	Yankees	16	9/25/2006	NYY	@	TBD	W 16-1	45	20	3	0	4	16	5	1	3	0	0	51	35	7	0	0	0	2	.444	.510	.778	1.288
7	Yankees	16	8/8/2001	NYY	@	TBD	W 16-1	42	17	1	0	3	16	8	1	10	0	0	52	27	4	0	1	0	0	.405	.500	.643	1.143
8	Yankees	13	5/19/2019	NYY	vs	TBR	W 13-5	36	10	2	1	3	12	9	0	9	1	0	45	23	6	0	0	1	0	.278	.422	.639	1.061
9	Yankees	13	5/16/2002	NYY	vs	TBD	W 13-0	39	15	2	0	4	13	7	1	2	0	0	47	29	6	0	0	0	1	.385	.489	.744	1.233
10	Yankees	12	6/19/2019	NYY	vs	TBR	W 12-1	32	9	1	0	2	12	7	1	7	1	0	40	16	3	0	0	0	1	.281	.425	.500	.925
11	Yankees	12	9/27/2018	NYY	@	TBR	W 12-1	37	13	2	1	4	11	4	0	10	1	0	43	29	7	0	2	0	1	.351	.395	.784	1.179
12	Yankees	12	9/26/2007	NYY	@	TBD	W 12-4	43	18	5	0	2	12	5	1	8	0	0	50	29	7	0	1	0	1	.419	.480	.674	1.154
13	Yankees	12	9/12/2006	NYY	vs	TBD	W 12-4	34	12	3	0	1	12	8	2	6	2	0	45	18	4	0	1	0	1	.353	.489	.529	1.018
14	Yankees	12	3/31/2004	NYY	@	TBD	W 12-1	35	11	0	0	4	12	8	2	4	1	0	45	23	4	0	0	0	2	.314	.467	.657	1.124
15	Yankees	12	4/4/2003	NYY	@	TBD	W 12-2	45	18	4	0	5	11	4	0	6	0	0	50	37	9	0	1	0	0	.400	.440	.822	1.262
16	Yankees	12	7/26/2002	NYY	@	TBD	W 12-9	34	10	2	0	2	12	10	1	9	2	1	46	18	4	0	1	0	0	.294	.457	.529	.986
17	Yankees	12	8/16/2001	NYY	vs	TBD	W 12-5	34	11	3	0	2	12	5	1	8	0	0	41	20	5	1	0	0	0	.324	.425	.588	1.013
18	Yankees	12	6/23/1999	NYY	@	TBD	W 12-4	43	19	2	1	3	12	6	1	5	1	1	51	32	6	0	1	0	2	.442	.510	.744	1.254
19	Yankees	11	4/3/2018	NYY	vs	TBR	W 11-4	34	11	2	0	2	10	6	0	14	0	0	41	19	4	1	0	0	1	.324	.425	.559	.984
20	Yankees	11	9/21/2016	NYY	@	TBR	W 11-5	43	17	2	0	3	11	3	0	8	0	0	47	28	5	0	1	0	0	.395	.426	.651	1.077
21	Yankees	11	5/11/2015	NYY	@	TBR	W 11-5	39	14	2	0	5	11	1	1	9	0	1	42	31	7	0	1	0	0	.359	.381	.795	1.176
22	Yankees	11	9/7/2009	NYY	vs	TBR	W 11-1	38	17	2	0	2	10	9	0	2	0	0	47	25	4	0	0	0	3	.447	.553	.658	1.211
23	Yankees	11	7/27/2009	NYY	@	TBR	W 11-4	41	15	3	1	4	11	7	0	2	0	1	48	32	8	0	0	1	1	.366	.458	.780	1.239
24	Yankees	11	9/7/2004	NYY	vs	TBD	W 11-2	37	16	6	0	1	11	4	1	6	0	1	42	25	7	0	0	1	2	.432	.500	.676	1.176
25	Yankees	11	7/21/2000	NYY	vs	TBD	W 11-1	39	17	3	0	1	11	4	1	7	1	0	44	23	4	0	0	0	2	.436	.500	.590	1.090