Between the 1980 and 1989 seasons, Nolan Ryan struck out the most hitters, with 2,167 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Nolan Ryan N. Ryan	2,167	314	122	104	.540	314	3.14	44	15	0	2094.0	1,603	730	835	128	894	53	0	34	8,704	123	9.31	3.84	2.42	0.55	24.9	10.3	1.19	.270	3.59	90	2.82	81	6.89	159.5
2	Fernando Valenzuela F. Valenzuela	1,644	298	128	103	.554	287	3.19	102	27	2	2144.2	1,876	760	869	133	838	16	5	54	8,957	81	6.90	3.52	1.96	0.56	18.4	9.4	1.27	.276	3.65	91	3.21	90	7.87	84
3	Jack Morris J. Morris	1,629	332	162	119	.577	332	3.66	133	20	0	2443.2	2,212	995	1,085	264	858	23	0	66	10,208	124	6.00	3.16	1.90	0.97	16.0	8.4	1.26	.262	4.00	92	3.89	94	8.15	66.7
4	Bert Blyleven B. Blyleven	1,480	291	123	103	.544	288	3.64	94	21	0	2078.1	1,984	841	919	212	557	73	1	26	8,623	44	6.41	2.41	2.66	0.92	17.2	6.5	1.22	.281	3.98	89	3.56	88	8.59	109.6
5	Bob Welch B. Welch	1,457	313	137	93	.596	311	3.21	47	22	0	2082.1	1,885	743	821	155	666	49	0	40	8,655	43	6.30	2.88	2.19	0.67	16.8	7.7	1.23	.273	3.55	90	3.34	92	8.15	63.4
6	Steve Carlton S. Carlton	1,453	254	104	84	.553	240	3.48	54	13	1	1732.1	1,604	670	774	135	631	12	6	50	7,271	76	7.55	3.28	2.30	0.70	20.0	8.7	1.29	.291	4.02	92	3.18	85	8.33	100.4
7	Dave Stieb D. Stieb	1,380	339	140	109	.562	331	3.32	92	27	1	2328.2	2,019	859	954	183	825	104	4	29	9,654	39	5.33	3.19	1.67	0.71	14.3	8.5	1.22	.256	3.69	80	3.77	93	7.80	77.5
8	Charlie Hough C. Hough	1,363	331	128	114	.529	282	3.67	93	11	2	2121.2	1,842	864	999	218	867	80	22	18	8,942	98	5.78	3.68	1.57	0.92	15.2	9.7	1.28	.253	4.24	90	4.14	103	7.81	-28.2
9	Mario Soto M. Soto	1,360	255	94	84	.528	213	3.37	70	12	4	1614.1	1,289	604	664	157	588	24	11	41	6,633	33	7.58	3.28	2.31	0.88	20.5	8.9	1.16	.251	3.70	91	3.44	93	7.19	44.2
10	Floyd Bannister F. Bannister	1,356	297	112	109	.507	294	3.98	50	11	0	1890.2	1,813	836	929	234	616	28	0	23	7,994	66	6.45	2.93	2.20	1.11	17.0	7.7	1.28	.274	4.42	96	3.94	96	8.63	35.4
11	Mike Scott M. Scott	1,324	295	114	90	.559	276	3.42	41	20	3	1803.2	1,594	685	761	140	537	31	13	43	7,436	37	6.61	2.68	2.47	0.70	17.8	7.2	1.18	.269	3.80	98	3.23	93	7.95	53.3
12	Frank Viola F. Viola	1,287	272	117	98	.544	271	3.84	56	11	0	1858.0	1,850	792	877	218	548	30	0	20	7,801	48	6.23	2.65	2.35	1.06	16.5	7.0	1.29	.285	4.25	91	3.83	94	8.96	46.2
13	Rick Sutcliffe R. Sutcliffe	1,285	310	116	93	.555	260	3.87	59	15	6	1860.0	1,764	799	866	160	745	28	27	56	7,887	74	6.22	3.60	1.72	0.77	16.3	9.4	1.35	.283	4.19	99	3.74	96	8.54	34.8
14	Mike Witt M. Witt	1,269	304	109	104	.512	272	3.78	70	10	5	1945.0	1,913	816	917	166	643	47	18	36	8,220	64	5.87	2.98	1.97	0.77	15.4	7.8	1.31	.287	4.24	95	3.61	88	8.85	109.1
15	Mark Langston M. Langston	1,253	200	86	76	.531	197	3.80	47	13	0	1374.1	1,206	580	653	146	668	26	1	16	5,866	39	8.21	4.37	1.88	0.96	21.4	11.4	1.36	.281	4.28	91	3.84	92	7.90	56
16	Frank Tanana F. Tanana	1,225	314	107	122	.467	304	3.89	51	8	0	1994.0	2,014	861	989	219	589	55	3	59	8,493	55	5.53	2.66	2.08	0.99	14.4	6.9	1.31	.280	4.46	97	3.91	97	9.09	27
17	Bruce Hurst B. Hurst	1,222	270	103	84	.551	250	4.01	64	15	0	1703.2	1,783	759	831	189	545	24	5	31	7,254	38	6.46	2.88	2.24	1.00	16.8	7.5	1.37	.302	4.39	96	3.76	94	9.42	41.4
18	Roger Clemens R. Clemens	1,215	175	95	45	.679	174	3.06	58	21	0	1284.2	1,088	437	476	95	371	32	0	16	5,243	31	8.51	2.60	3.27	0.67	23.2	7.1	1.14	.281	3.33	73	2.79	69	7.62	178.3
19	Mike Krukow M. Krukow	1,171	278	98	91	.519	274	3.81	37	8	1	1711.1	1,690	724	823	156	570	36	1	60	7,302	59	6.16	3.00	2.05	0.82	16.0	7.8	1.32	.286	4.33	105	3.62	99	8.89	8.6
20	Dwight Gooden D. Gooden	1,168	177	100	39	.719	175	2.64	52	19	1	1291.0	1,053	379	423	65	379	18	1	17	5,215	26	8.14	2.64	3.08	0.45	22.4	7.3	1.11	.276	2.95	75	2.52	70	7.34	155.6
21	Jim Clancy J. Clancy	1,145	329	119	126	.486	317	4.09	61	10	1	2017.2	1,996	918	1,017	207	711	27	8	30	8,582	72	5.11	3.17	1.61	0.92	13.3	8.3	1.34	.276	4.54	100	4.04	100	8.90	1.9
22	Ron Guidry R. Guidry	1,126	252	111	72	.607	232	3.66	55	10	1	1639.2	1,599	666	719	180	412	11	9	21	6,800	33	6.18	2.26	2.73	0.99	16.6	6.1	1.23	.280	3.95	92	3.56	89	8.78	80
23	Mike Moore M. Moore	1,109	262	85	107	.443	252	4.13	62	12	2	1698.2	1,691	779	865	160	618	31	6	32	7,219	59	5.88	3.27	1.79	0.85	15.4	8.6	1.36	.289	4.58	99	3.82	90	8.96	74.3
24	Rick Rhoden R. Rhoden	1,092	294	109	100	.522	288	3.65	48	10	1	1918.1	1,954	779	856	139	596	32	4	57	8,082	63	5.12	2.80	1.83	0.65	13.5	7.4	1.33	.292	4.02	98	3.52	94	9.17	46.3
25	Danny Darwin D. Darwin	1,090	417	95	101	.485	184	3.48	43	8	27	1663.1	1,579	643	738	145	519	38	127	60	6,995	30	5.90	2.81	2.10	0.78	15.6	7.4	1.26	.276	3.99	91	3.57	94	8.54	40.7