Between the 1900 and 1909 seasons, Vic Willis started the most games, with 372 starts.

Interpreted as:

most regular-season starts as a pitcher in the 1900s

	NAME	GS	G	W	L	W%	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Vic Willis V. Willis	372	398	188	172	.522	2.57	1,304	312	43	6	3130.1	2,856	895	1,238	49	886	96	26	12,655	70	3.75	2.55	1.47	0.14	10.3	7.0	1.20	.272	3.56	89	2.81	94	8.21	58
2	Cy Young C. Young	366	403	230	146	.612	2.12	1,565	337	45	9	3344.0	2,951	787	1,126	45	394	68	34	12,862	48	4.21	1.06	3.97	0.12	12.2	3.1	1.00	.269	3.03	73	2.17	75	7.94	274.6
3	Christy Mathewson C. Mathewson	345	389	236	112	.678	1.98	1,799	282	61	16	2974.2	2,435	654	952	37	644	50	39	11,687	90	5.44	1.95	2.79	0.11	15.4	5.5	1.04	.262	2.88	71	2.12	73	7.37	248.9
4	Joe McGinnity J. McGinnity	340	417	218	126	.634	2.65	994	276	28	22	3075.0	2,918	907	1,272	49	719	153	66	12,613	26	2.91	2.10	1.38	0.14	7.9	5.7	1.18	.268	3.72	86	2.98	95	8.54	59.4
5	Jack Powell J. Powell	334	377	160	163	.495	2.88	1,209	277	32	14	2876.2	2,720	921	1,241	73	638	69	40	11,532	47	3.78	2.00	1.89	0.23	10.5	5.5	1.17	.277	3.88	98	2.75	97	8.51	28.1
6	Rube Waddell R. Waddell	328	385	183	139	.568	2.11	2,251	251	49	3	2835.1	2,343	666	1,000	32	772	105	46	11,197	72	7.15	2.45	2.92	0.10	20.1	6.9	1.10	.288	3.17	74	1.98	70	7.44	258.7
7	Jack Chesbro J. Chesbro	315	373	192	123	.610	2.61	1,237	245	35	5	2747.2	2,482	796	1,107	36	631	102	50	10,973	57	4.05	2.07	1.96	0.12	11.3	5.8	1.13	.273	3.63	89	2.59	89	8.13	107.9
8	Eddie Plank E. Plank	314	334	186	121	.606	2.42	1,342	263	36	1	2666.0	2,360	716	955	26	599	140	16	10,645	57	4.53	2.02	2.24	0.09	12.6	5.6	1.11	.273	3.22	83	2.42	86	7.97	120.4
9	George Mullin G. Mullin	298	330	157	134	.540	2.66	1,091	258	25	6	2592.1	2,434	765	1,116	19	833	78	30	10,636	67	3.79	2.89	1.31	0.07	10.3	7.8	1.26	.280	3.87	97	2.71	101	8.45	-5.9
10	Bill Dinneen B. Dinneen	290	325	147	141	.510	2.82	953	254	24	7	2565.1	2,369	805	1,080	66	635	49	31	10,285	49	3.34	2.23	1.50	0.23	9.3	6.2	1.17	.268	3.79	95	2.96	101	8.31	8.2
11	Al Orth A. Orth	284	315	138	143	.491	3.21	749	229	25	4	2393.2	2,429	853	1,134	51	439	61	29	9,701	34	2.82	1.65	1.71	0.19	7.7	4.5	1.20	.283	4.26	105	2.84	94	9.13	55.6
12	Doc White D. White	278	309	154	115	.572	2.20	1,105	215	38	2	2315.0	2,022	565	806	26	499	86	27	9,157	50	4.30	1.94	2.21	0.10	12.1	5.4	1.09	.268	3.13	85	2.42	95	7.86	22.5
13	Bill Donovan B. Donovan	273	295	154	112	.579	2.57	1,293	246	31	7	2426.0	2,118	694	938	21	838	71	22	9,906	51	4.80	3.11	1.54	0.08	13.1	8.5	1.22	.273	3.48	92	2.68	97	7.86	28.5
14	Harry Howell H. Howell	255	309	116	138	.457	2.60	925	221	20	5	2337.0	2,165	676	1,014	26	595	86	49	9,424	44	3.56	2.29	1.55	0.10	9.8	6.3	1.18	.275	3.91	89	2.70	97	8.34	23.8
15	Chick Fraser C. Fraser	251	288	118	134	.468	3.29	792	219	17	5	2204.2	2,175	805	1,155	42	836	117	34	9,342	72	3.23	3.41	0.95	0.17	8.5	8.9	1.37	.282	4.71	108	3.40	110	8.88	-72.2
16	Tully Sparks T. Sparks	249	282	113	128	.469	2.69	723	194	19	8	2150.2	2,036	642	945	30	542	75	30	8,716	20	3.03	2.27	1.33	0.13	8.3	6.2	1.20	.273	3.95	95	2.83	97	8.52	14.1
17	Sam Leever S. Leever	249	306	166	72	.697	2.33	678	200	35	8	2137.2	1,966	554	777	20	435	70	48	8,539	38	2.85	1.83	1.56	0.08	7.9	5.1	1.12	.265	3.27	81	2.72	92	8.28	62.6
18	Addie Joss A. Joss	248	273	155	92	.628	1.87	871	225	44	5	2219.2	1,792	461	695	17	346	56	22	8,479	28	3.53	1.40	2.52	0.07	10.3	4.1	0.96	.247	2.82	69	2.25	86	7.27	83.5
19	Tom Hughes T. Hughes	248	298	104	135	.435	2.99	1,115	195	22	9	2095.1	2,029	697	984	31	637	77	44	8,665	66	4.79	2.74	1.75	0.13	12.9	7.4	1.27	.294	4.23	109	2.64	98	8.72	10.4
20	Deacon Phillippe D. Phillippe	243	296	154	90	.631	2.50	828	204	24	7	2158.1	2,071	600	842	27	288	49	47	8,565	42	3.45	1.20	2.88	0.11	9.7	3.4	1.09	.277	3.51	85	2.45	80	8.64	143.9
21	Jack Taylor J. Taylor	243	265	129	118	.522	2.49	584	235	19	5	2230.1	2,092	616	960	35	490	71	22	9,049	37	2.36	1.98	1.19	0.14	6.5	5.4	1.16	.261	3.87	85	3.04	102	8.44	-21.1
22	Casey Patten C. Patten	238	270	106	128	.453	3.36	757	206	17	4	2062.1	2,154	770	1,079	40	557	74	28	8,622	28	3.30	2.43	1.36	0.17	8.8	6.5	1.31	.294	4.71	116	2.98	105	9.40	-27.2
23	Dummy Taylor D. Taylor	237	274	116	106	.523	2.75	767	160	21	3	1916.1	1,877	585	870	38	551	72	30	7,952	47	3.60	2.59	1.39	0.18	9.6	6.9	1.27	.282	4.09	94	2.99	100	8.82	-5.8
24	Jesse Tannehill J. Tannehill	229	248	138	80	.633	2.59	738	185	25	2	1935.1	1,880	557	779	32	320	95	19	7,771	20	3.43	1.49	2.31	0.15	9.5	4.1	1.14	.281	3.62	90	2.68	93	8.74	52.3
25	Bob Ewing B. Ewing	228	252	108	103	.512	2.37	884	184	15	4	2020.1	1,831	531	805	24	513	48	24	8,011	42	3.94	2.29	1.72	0.11	11.0	6.4	1.16	.276	3.59	83	2.49	85	8.16	106.9