| NAME | GS | SEASON | TM | G | W | L | W% | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Cease | 32 | 2021 |  CWS | 32 | 13 | 7 | .650 | 3.91 | 226 | 1 | 1 | 0 | 165.2 | 139 | 72 | 77 | 20 | 68 | 9 | 0 | 0 | 708 | 13 | 12.28 | 3.69 | 3.32 | 1.09 | 31.9 | 9.6 | 1.25 | .309 | 4.18 | 90 | 3.40 | 76 | 7.55 | 18.9 |
| 2 |  | L. Giolito | 31 | 2021 | CWS | 31 | 11 | 9 | .550 | 3.53 | 201 | 1 | 0 | 0 | 178.2 | 145 | 70 | 74 | 27 | 52 | 2 | 0 | 1 | 720 | 12 | 10.13 | 2.62 | 3.87 | 1.36 | 27.9 | 7.2 | 1.10 | .269 | 3.73 | 81 | 3.78 | 85 | 7.30 | 13 |
| 3 |  | D. Keuchel | 30 | 2021 | CWS | 32 | 9 | 9 | .500 | 5.28 | 95 | 0 | 0 | 0 | 162.0 | 189 | 95 | 105 | 25 | 59 | 7 | 0 | 1 | 720 | 5 | 5.28 | 3.28 | 1.61 | 1.39 | 13.2 | 8.2 | 1.53 | .307 | 5.83 | 121 | 5.22 | 117 | 10.50 | -13.1 |
| 4 | | L. Lynn | 28 | 2021 | CWS | 28 | 11 | 6 | .647 | 2.69 | 176 | 1 | 1 | 0 | 157.0 | 123 | 47 | 52 | 18 | 45 | 2 | 0 | 2 | 641 | 5 | 10.09 | 2.58 | 3.91 | 1.03 | 27.5 | 7.0 | 1.07 | .263 | 2.98 | 62 | 3.31 | 74 | 7.05 | 19.4 |
| 5 |  | C. Rodón | 24 | 2021 | CWS | 24 | 13 | 5 | .722 | 2.37 | 185 | 1 | 1 | 0 | 132.2 | 91 | 35 | 39 | 13 | 36 | 8 | 0 | 1 | 534 | 7 | 12.55 | 2.44 | 5.14 | 0.88 | 34.6 | 6.7 | 0.96 | .267 | 2.65 | 54 | 2.64 | 59 | 6.17 | 25.8 |
| 6 | | R. López | 9 | 2021 | CWS | 20 | 4 | 4 | .500 | 3.43 | 55 | 0 | 0 | 0 | 57.2 | 42 | 22 | 27 | 10 | 13 | 0 | 3 | 0 | 222 | 1 | 8.58 | 2.03 | 4.23 | 1.56 | 24.8 | 5.9 | 0.95 | .222 | 4.21 | 79 | 4.19 | 94 | 6.55 | 1.7 |
| 7 | | M. Kopech | 4 | 2021 | CWS | 44 | 4 | 3 | .571 | 3.50 | 103 | 0 | 0 | 0 | 69.1 | 54 | 27 | 27 | 9 | 24 | 1 | 1 | 1 | 285 | 3 | 13.37 | 3.12 | 4.29 | 1.17 | 36.1 | 8.4 | 1.13 | .304 | 3.50 | 80 | 2.96 | 67 | 7.01 | 11.1 |
| 8 | | J. Lambert | 3 | 2021 | CWS | 4 | 1 | 1 | .500 | 6.23 | 10 | 0 | 0 | 0 | 13.0 | 16 | 9 | 9 | 3 | 6 | 2 | 0 | 0 | 60 | 0 | 6.92 | 4.15 | 1.67 | 2.08 | 16.7 | 10.0 | 1.69 | .333 | 6.23 | 143 | 6.47 | 145 | 11.08 | -2.8 |
| 9 | | R. Burr | 1 | 2021 | CWS | 34 | 2 | 1 | .667 | 2.45 | 33 | 0 | 0 | 0 | 36.2 | 28 | 10 | 11 | 3 | 21 | 1 | 8 | 0 | 151 | 5 | 8.10 | 5.15 | 1.57 | 0.74 | 21.9 | 13.9 | 1.34 | .269 | 2.70 | 56 | 4.23 | 95 | 6.87 | 0.9 |
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