Greg Maddux has the most career starts when allowing 2 or fewer runs, with 398 starts.

Interpreted as:

most regular-season starts by a player with 2 runs or less allowed

	NAME	GS	R	G	W	L	W%	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Greg Maddux G. Maddux	398	458	400	269	38	.876	1.30	1,994	93	35	0	2919.0	2,079	421	92	456	60	1	67	11,041	29	6.15	1.41	4.37	0.28	18.1	4.1	0.87	.235	1.41	6.41
2	Roger Clemens R. Clemens	387	414	389	279	32	.897	1.17	2,817	93	46	0	2891.2	1,844	375	94	778	62	0	21	11,115	58	8.77	2.42	3.62	0.29	25.3	7.0	0.91	.238	1.29	5.74
3	Nolan Ryan N. Ryan	384	425	415	252	54	.824	1.11	3,236	153	61	3	2952.1	1,523	363	61	1,299	64	12	18	11,453	101	9.86	3.96	2.49	0.19	28.3	11.3	0.96	.215	1.30	4.64
4	Don Sutton D. Sutton	376	444	393	249	50	.833	1.20	1,999	140	58	5	2953.2	1,959	393	118	629	27	12	42	11,262	44	6.09	1.92	3.18	0.36	17.7	5.6	0.88	.217	1.35	5.97
5	Walter Johnson W. Johnson	354	412	475	322	83	.795	0.55	2,176	313	110	32	3448.0	2,172		18	669	98	115			72	5.68	1.75	3.25	0.05		5.2	0.82	.217	1.08	5.67
6	Tom Glavine T. Glavine	338	391	338	216	34	.864	1.34	1,448	48	25	0	2383.2	1,724	354	102	651	30	0	43	9,280	18	5.47	2.46	2.22	0.39	15.6	7.0	1.00	.230	1.48	6.51
7	Tom Seaver T. Seaver	332	376	341	236	49	.828	1.13	2,161	185	61	1	2728.2	1,731	344	98	657	36	6	49	10,365	54	7.13	2.17	3.29	0.32	20.8	6.3	0.88	.220	1.24	5.71
8	Tommy John T. John	330	417	387	209	42	.833	1.28	1,287	121	46	3	2579.0	1,983	367	86	570	38	21	39	9,976	71	4.49	1.99	2.26	0.30	12.9	5.7	0.99	.237	1.46	6.92
9	Steve Carlton S. Carlton	315	372	342	231	43	.843	1.14	2,103	178	55	2	2630.1	1,751	332	80	754	25	12	46	10,117	81	7.20	2.58	2.79	0.27	20.8	7.5	0.95	.234	1.27	5.99
10	Gaylord Perry G. Perry	310	402	383	227	52	.814	1.15	1,829	198	53	10	2753.2	1,873	353	89	606	45	29	72	10,512	55	5.98	1.98	3.02	0.29	17.4	5.8	0.90	.225	1.31	6.12
11	Zack Greinke Z. Greinke	308	345	347	181	36	.834	1.41	1,875	13	5	1	2084.2	1,511	327	102	389	42	7	12	7,972	53	8.09	1.68	4.82	0.44	23.5	4.9	0.91	.253	1.49	6.52
12	Randy Johnson R. Johnson	306	348	319	222	27	.892	1.24	2,893	75	37	2	2301.1	1,410	316	113	640	85	7	10	8,830	42	11.31	2.50	4.52	0.44	32.8	7.2	0.89	.254	1.36	5.51
13	Phil Niekro P. Niekro	306	422	436	226	53	.810	1.25	1,661	158	45	29	2668.1	1,882	372	105	729	44	81	31	10,381	81	5.60	2.46	2.28	0.35	16.0	7.0	0.98	.227	1.42	6.35
14	Bert Blyleven B. Blyleven	304	348	309	211	36	.854	1.13	1,888	156	60	0	2440.2	1,704	307	87	560	60	3	20	9,367	36	6.96	2.07	3.37	0.32	20.2	6.0	0.93	.239	1.28	6.28
15	Warren Spahn W. Spahn	302	413	379	258	53	.830	1.18	1,396	266	63	28	2789.0	1,927	366	117	634	16	64	21	10,676	25	4.50	2.05	2.20	0.38	13.1	5.9	0.92	.213	1.33	6.22
16	Christy Mathewson C. Mathewson	298	337	368	276	41	.871	0.32	1,470	251	79	25	2716.2	1,867		27	391	20	64			45	4.87	1.30	3.76	0.09		3.9	0.83	.225	1.12	6.19
17	Grover Alexander G. Alexander	296	356	373	259	51	.835	0.89	1,244	270	90	32	2784.0	1,976		33	385	28	71		10,449	15	4.02	1.24	3.23	0.11	11.9	3.7	0.85	.222	1.15	6.39
18	Justin Verlander J. Verlander	294	320	294	200	32	.862	1.29	2,126	23	9	0	2034.1	1,310	291	118	471	56	0	10	7,778	43	9.41	2.08	4.51	0.52	27.3	6.1	0.88	.238	1.42	5.80
19	Clayton Kershaw C. Kershaw	290	280	293	184	26	.876	1.20	2,117	24	15	0	1955.1	1,211	261	90	403	23	1	16	7,350	68	9.74	1.85	5.25	0.41	28.8	5.5	0.83	.238	1.29	5.57
20	Jim Palmer J. Palmer	285	351	313	212	34	.862	1.16	1,380	165	53	4	2411.0	1,595	310	97	678	17	12	13	9,271	44	5.15	2.53	2.04	0.36	14.9	7.3	0.94	.211	1.31	5.95
21	Max Scherzer M. Scherzer	282	306	290	173	28	.861	1.36	2,275	10	5	0	1887.0	1,189	285	118	435	65	1	8	7,195	28	10.85	2.07	5.23	0.56	31.6	6.0	0.86	.249	1.46	5.67
22	Jamie Moyer J. Moyer	269	359	318	180	36	.833	1.53	1,198	28	10	0	1965.2	1,447	334	95	472	66	14	18	7,686	20	5.49	2.16	2.54	0.43	15.6	6.1	0.98	.231	1.64	6.63
23	Mike Mussina M. Mussina	267	325	268	198	14	.934	1.40	1,595	48	23	0	1959.0	1,406	304	91	348	23	0	7	7,432	26	7.33	1.60	4.58	0.42	21.5	4.7	0.90	.245	1.49	6.46
24	Eddie Plank E. Plank	267	332	345	236	42	.849	0.52	1,316	236	69	21	2489.2	1,669		14	535	87	67			31	4.76	1.93	2.46	0.05		5.9	0.89	.233	1.20	6.03
25	CC Sabathia	262	296	263	177	20	.898	1.37	1,623	27	12	0	1790.1	1,258	273	87	487	61	0	15	6,953	28	8.16	2.45	3.33	0.44	23.3	7.0	0.97	.249	1.49	6.32