Red Ruffing has the most career starts when allowing 5+ earned runs, with 145 starts.

Interpreted as:

most regular-season starts by a player with 5 earned runs or more

	NAME	GS	ER	G	W	L	W%	ERA	SO	CG	SHO	SV	IP	H	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Red Ruffing R. Ruffing	145	895	147	26	96	.213	8.42	445	52	0	0	956.1	1,391	959	111	441	18	0		4,632	19	4.19	4.15	1.01	1.04	9.6	9.5	1.92	.354	9.03	13.09
2	Earl Whitehill E. Whitehill	144	870	144	27	91	.229	8.67	358	35	0	0	902.2	1,356	937	95	490	29	0		4,500	19	3.57	4.89	0.73	0.95	8.0	10.9	2.05	.357	9.34	13.52
3	Jamie Moyer J. Moyer	142	826	143	15	86	.149	10.18	427	0	0	0	730.0	1,165	860	220	279	34	0	21	3,593	13	5.26	3.44	1.53	2.71	11.9	7.8	1.98	.359	10.60	14.36
4	Jack Morris J. Morris	136	793	136	27	85	.241	9.27	461	13	0	0	769.2	1,116	818	176	380	23	0	34	3,745	61	5.39	4.44	1.21	2.06	12.3	10.1	1.94	.348	9.57	13.05
5	Ted Lyons T. Lyons	129	849	135	21	101	.172	8.31	258	62	0	0	919.2	1,415	914	99	354	14	2		4,452	18	2.52	3.46	0.73	0.97	5.8	8.0	1.92	.353	8.94	13.85
6	Early Wynn E. Wynn	125	746	126	8	93	.079	9.34	349	21	0	0	719.0	1,083	781	124	392	18	0	9	3,578	13	4.37	4.91	0.89	1.55	9.8	11.0	2.05	.356	9.78	13.56
7	Bert Blyleven B. Blyleven	124	698	124	4	92	.042	9.04	489	7	0	0	694.2	1,030	729	151	225	42	0	20	3,313	26	6.34	2.92	2.17	1.96	14.8	6.8	1.81	.365	9.44	13.34
8	Don Sutton D. Sutton	123	698	123	9	87	.094	10.05	407	3	0	0	625.1	972	721	154	255	19	0	26	3,073	21	5.86	3.67	1.60	2.22	13.2	8.3	1.96	.366	10.38	13.99
9	Bobo Newsom B. Newsom	123	780	126	17	93	.155	8.66	472	40	0	0	811.0	1,162	825	88	470	17	1		4,006	16	5.24	5.22	1.00	0.98	11.8	11.7	2.01	.363	9.16	12.90
10	Phil Niekro P. Niekro	122	707	123	6	94	.060	9.31	395	12	0	0	683.1	1,021	735	139	306	23	0	13	3,335	34	5.20	4.03	1.29	1.83	11.8	9.2	1.94	.357	9.68	13.45
11	Livan Hernandez L. Hernandez	121	752	125	12	87	.121	10.48	395	3	0	0	645.2	1,047	779	157	303	16	0	27	3,236	19	5.51	4.22	1.30	2.19	12.2	9.4	2.09	.376	10.86	14.59
12	Nolan Ryan N. Ryan	121	712	121	10	95	.095	9.72	660	10	0	0	659.0	831	744	122	468	32	0	22	3,251	68	9.01	6.39	1.41	1.67	20.3	14.4	1.97	.360	10.16	11.35
13	Tim Wakefield T. Wakefield	120	731	124	14	86	.140	10.37	392	4	0	0	634.1	963	768	183	295	42	1	15	3,163	37	5.56	4.19	1.33	2.60	12.4	9.3	1.98	.347	10.90	13.66
14	Roger Clemens R. Clemens	119	691	119	14	76	.156	9.32	593	3	0	0	667.1	950	716	127	332	42	0	23	3,259	33	8.00	4.48	1.79	1.71	18.2	10.2	1.92	.380	9.66	12.81
15	David Wells D. Wells	118	704	119	10	74	.119	10.40	337	4	0	0	609.1	1,043	719	168	178	23	0	11	2,998	15	4.98	2.63	1.89	2.48	11.2	5.9	2.00	.382	10.62	15.41
16	Fergie Jenkins F. Jenkins	118	686	120	17	76	.183	9.12	470	15	0	0	677.0	1,019	703	152	216	19	0	25	3,242	13	6.25	2.87	2.18	2.02	14.5	6.7	1.82	.364	9.35	13.55
17	Bobby Witt B. Witt	117	675	117	11	84	.116	10.89	432	4	0	0	557.2	856	701	116	404	15	0	13	2,875	41	6.97	6.52	1.07	1.87	15.0	14.1	2.26	.388	11.31	13.81
18	Bartolo Colon B. Colon	116	692	116	7	94	.069	11.26	390	2	0	0	553.0	940	717	178	233	19	0	16	2,801	9	6.35	3.79	1.67	2.90	13.9	8.3	2.12	.385	11.67	15.30
19	Robin Roberts R. Roberts	116	668	116	24	79	.233	8.20	332	31	0	0	733.0	1,078	690	180	177	9	0	14	3,404	6	4.08	2.17	1.88	2.21	9.8	5.2	1.71	.332	8.47	13.24
20	Mike Moore M. Moore	115	662	115	5	86	.055	10.87	285	5	0	0	548.1	879	684	109	333	16	0	23	2,787	48	4.68	5.47	0.86	1.79	10.2	11.9	2.21	.377	11.23	14.43
21	Gaylord Perry G. Perry	114	665	114	7	84	.077	9.33	398	14	0	0	641.1	988	689	121	240	14	0	27	3,079	34	5.59	3.37	1.66	1.70	12.9	7.8	1.91	.376	9.67	13.86
22	Tom Glavine T. Glavine	113	648	113	8	86	.085	10.63	322	0	0	0	548.2	927	670	113	305	12	0	37	2,823	14	5.28	5.00	1.06	1.85	11.4	10.8	2.25	.393	10.99	15.21
23	Kenny Rogers K. Rogers	111	671	112	10	64	.135	10.53	340	5	0	0	573.1	919	702	137	237	35	0	8	2,860	17	5.34	3.72	1.43	2.15	11.9	8.3	2.02	.370	11.02	14.43
24	Steve Carlton S. Carlton	111	648	112	11	74	.129	9.23	522	10	0	0	632.0	917	674	119	335	6	0	35	3,104	32	7.43	4.77	1.56	1.69	16.8	10.8	1.98	.376	9.60	13.06
25	Warren Spahn W. Spahn	111	616	112	15	74	.169	8.50	285	16	0	0	652.1	966	643	145	259	12	0	17	3,131	22	3.93	3.57	1.10	2.00	9.1	8.3	1.88	.338	8.87	13.33