Nelson Cruz has the most career strikeouts by a player 40 or older, with 349 strikeouts.

Interpreted as:

most strikeouts after turning 40 years old by a player

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Nelson Cruz N. Cruz	349	366	1,289	171	332	48	2	63	206	131	17	8	0	1,450	573	113	0	13	17	40	.258	.331	.445	.776
2	Julio Franco J. Franco	336	637	1,434	181	409	72	7	32	213	164	5	21	6	1,619	591	111	4	12	17	57	.285	.358	.412	.770
3	Carlton Fisk C. Fisk	308	537	1,781	205	473	83	4	72	282	191	24	12	5	2,011	780	159	2	13	34	54	.266	.342	.438	.780
4	Rickey Henderson R. Henderson	304	469	1,488	281	377	68	6	31	137	300	14	109	34	1,816	550	105	4	10	2	26	.253	.381	.370	.751
5	Dave Winfield D. Winfield	275	425	1,548	212	417	81	8	59	233	174	2	7	8	1,734	691	148	2	8	19	37	.269	.342	.446	.789
6	Raul Ibanez R. Ibanez	237	303	946	110	206	38	7	44	125	101	2	4	2	1,050	390	89	0	1	4	21	.218	.294	.412	.707
7	Darrell Evans D. Evans	205	361	1,089	149	246	30	1	60	180	198	2	7	7	1,299	458	91	0	10	16	16	.226	.343	.421	.764
8	Ichiro Suzuki I. Suzuki	204	592	1,329	159	347	39	13	6	85	103	5	37	11	1,456	430	58	11	8	4	17	.261	.315	.324	.638
9	Andres Galarraga A. Galarraga	203	284	769	89	218	43	1	31	127	65	15	4	8	855	356	75	0	6	8	22	.283	.349	.463	.811
10	Willie Mays W. Mays	203	268	794	124	190	39	5	27	89	183	4	25	8	990	320	71	6	3	16	21	.239	.383	.403	.786
11	Edgar Martinez E. Martinez	202	286	983	117	274	48	0	36	161	150	9	1	1	1,152	430	84	0	10	17	32	.279	.376	.437	.813
12	Craig Biggio C. Biggio	196	286	1,065	147	265	64	3	31	112	63	12	7	5	1,162	428	98	12	10	1	20	.249	.296	.402	.698
13	Reggie Jackson R. Jackson	184	219	662	89	145	22	3	26	84	109	6	3	2	780	251	51	0	3	10	15	.219	.333	.379	.712
14	Omar Vizquel O. Vizquel	177	509	1,556	156	392	58	9	7	129	127	3	37	20	1,736	489	74	36	14	15	32	.252	.307	.314	.621
15	Pete Rose P. Rose	177	728	2,556	321	691	90	18	5	237	320	23	31	20	2,932	832	113	14	19	28	53	.270	.354	.326	.680
16	Matt Stairs M. Stairs	175	354	604	79	138	23	1	24	84	85	8	3	1	701	235	48	0	4	14	12	.228	.330	.389	.719
17	Graig Nettles G. Nettles	175	484	1,143	134	264	47	3	40	174	152	3	1	1	1,308	437	90	0	10	20	28	.231	.320	.382	.703
18	Tony Perez T. Perez	167	364	922	78	242	49	5	20	144	98	1	1	3	1,030	361	74	0	9	7	30	.262	.331	.392	.723
19	Jim Thome J. Thome	162	170	488	63	129	24	0	30	89	81	2	0	0	572	243	54	0	1	8	13	.264	.371	.498	.869
20	Carl Yastrzemski C. Yastrzemski	150	476	1,637	185	434	85	3	49	244	214	4	0	5	1,870	672	137	1	14	21	45	.265	.349	.411	.759
21	Willie McCovey W. McCovey	150	273	817	74	191	36	2	28	137	85	2	1	2	912	315	66	0	8	12	22	.234	.305	.386	.690
22	Jason Giambi J. Giambi	137	221	466	51	96	20	0	25	76	69	10	0	1	551	191	45	0	6	4	16	.206	.318	.410	.727
23	Jack Quinn J. Quinn	137	368	506	23	81	13	0	1	49	21	1	0		564	97	14	36				.160	.195	.192	.387
24	Paul Molitor P. Molitor	132	296	1,182	150	355	70	12	15	175	102	2	23	6	1,314	494	97	3	25	17	33	.300	.350	.418	.768
25	Barry Bonds B. Bonds	131	332	905	211	261	50	3	79	199	348	18	11	1	1,277	554	132	0	6	126	23	.288	.491	.612	1.103