Between the 1900 and 1909 seasons, Rube Waddell struck out the most hitters, with 2,251 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Rube Waddell R. Waddell	2,251	385	183	139	.568	328	2.11	251	49	3	2835.1	2,343	666	1,000	32	772	105	46	11,197	72	7.15	2.45	2.92	0.10	20.1	6.9	1.10	.288	3.17	74	1.98	70	7.44	258.7
2	Christy Mathewson C. Mathewson	1,799	389	236	112	.678	345	1.98	282	61	16	2974.2	2,435	654	952	37	644	50	39	11,687	90	5.44	1.95	2.79	0.11	15.4	5.5	1.04	.262	2.88	71	2.12	73	7.37	248.9
3	Cy Young C. Young	1,565	403	230	146	.612	366	2.12	337	45	9	3344.0	2,951	787	1,126	45	394	68	34	12,862	48	4.21	1.06	3.97	0.12	12.2	3.1	1.00	.269	3.03	73	2.17	75	7.94	274.6
4	Eddie Plank E. Plank	1,342	334	186	121	.606	314	2.42	263	36	1	2666.0	2,360	716	955	26	599	140	16	10,645	57	4.53	2.02	2.24	0.09	12.6	5.6	1.11	.273	3.22	83	2.42	86	7.97	120.4
5	Vic Willis V. Willis	1,304	398	188	172	.522	372	2.57	312	43	6	3130.1	2,856	895	1,238	49	886	96	26	12,655	70	3.75	2.55	1.47	0.14	10.3	7.0	1.20	.272	3.56	89	2.81	94	8.21	58
6	Bill Donovan B. Donovan	1,293	295	154	112	.579	273	2.57	246	31	7	2426.0	2,118	694	938	21	838	71	22	9,906	51	4.80	3.11	1.54	0.08	13.1	8.5	1.22	.273	3.48	92	2.68	97	7.86	28.5
7	Jack Chesbro J. Chesbro	1,237	373	192	123	.610	315	2.61	245	35	5	2747.2	2,482	796	1,107	36	631	102	50	10,973	57	4.05	2.07	1.96	0.12	11.3	5.8	1.13	.273	3.63	89	2.59	89	8.13	107.9
8	Jack Powell J. Powell	1,209	377	160	163	.495	334	2.88	277	32	14	2876.2	2,720	921	1,241	73	638	69	40	11,532	47	3.78	2.00	1.89	0.23	10.5	5.5	1.17	.277	3.88	98	2.75	97	8.51	28.1
9	Tom Hughes T. Hughes	1,115	298	104	135	.435	248	2.99	195	22	9	2095.1	2,029	697	984	31	637	77	44	8,665	66	4.79	2.74	1.75	0.13	12.9	7.4	1.27	.294	4.23	109	2.64	98	8.72	10.4
10	Doc White D. White	1,105	309	154	115	.572	278	2.20	215	38	2	2315.0	2,022	565	806	26	499	86	27	9,157	50	4.30	1.94	2.21	0.10	12.1	5.4	1.09	.268	3.13	85	2.42	95	7.86	22.5
11	George Mullin G. Mullin	1,091	330	157	134	.540	298	2.66	258	25	6	2592.1	2,434	765	1,116	19	833	78	30	10,636	67	3.79	2.89	1.31	0.07	10.3	7.8	1.26	.280	3.87	97	2.71	101	8.45	-5.9
12	Joe McGinnity J. McGinnity	994	417	218	126	.634	340	2.65	276	28	22	3075.0	2,918	907	1,272	49	719	153	66	12,613	26	2.91	2.10	1.38	0.14	7.9	5.7	1.18	.268	3.72	86	2.98	95	8.54	59.4
13	Bill Dinneen B. Dinneen	953	325	147	141	.510	290	2.82	254	24	7	2565.1	2,369	805	1,080	66	635	49	31	10,285	49	3.34	2.23	1.50	0.23	9.3	6.2	1.17	.268	3.79	95	2.96	101	8.31	8.2
14	Chief Bender C. Bender	935	221	102	71	.590	173	2.43	147	21	8	1549.0	1,309	419	589	20	362	59	45	6,118	38	5.43	2.10	2.58	0.12	15.3	5.9	1.08	.272	3.42	90	2.17	82	7.61	76.5
15	Harry Howell H. Howell	925	309	116	138	.457	255	2.60	221	20	5	2337.0	2,165	676	1,014	26	595	86	49	9,424	44	3.56	2.29	1.55	0.10	9.8	6.3	1.18	.275	3.91	89	2.70	97	8.34	23.8
16	Ed Walsh E. Walsh	901	234	110	63	.636	175	1.68	138	36	15	1642.1	1,276	307	464	7	312	34	54	6,282	51	4.94	1.71	2.89	0.04	14.3	5.0	0.97	.252	2.54	70	1.83	80	6.99	74.3
17	Bob Ewing B. Ewing	884	252	108	103	.512	228	2.37	184	15	4	2020.1	1,831	531	805	24	513	48	24	8,011	42	3.94	2.29	1.72	0.11	11.0	6.4	1.16	.276	3.59	83	2.49	85	8.16	106.9
18	Addie Joss A. Joss	871	273	155	92	.628	248	1.87	225	44	5	2219.2	1,792	461	695	17	346	56	22	8,479	28	3.53	1.40	2.52	0.07	10.3	4.1	0.96	.247	2.82	69	2.25	86	7.27	83.5
19	Red Ames R. Ames	844	174	72	50	.590	139	2.45	91	9	7	1186.2	982	323	475	11	460	24	28	4,806	78	6.40	3.49	1.83	0.08	17.6	9.6	1.22	.280	3.60	92	2.24	81	7.45	67.6
20	Earl Moore E. Moore	833	214	104	87	.545	197	2.51	167	20	2	1727.1	1,527	482	744	29	595	66	14	7,139	57	4.34	3.10	1.40	0.15	11.7	8.3	1.23	.267	3.88	86	2.95	101	7.96	-9.4
21	Togie Pittinger T. Pittinger	832	262	115	113	.504	227	3.10	187	23	3	2040.2	2,017	702	985	39	734	96	30	8,579	43	3.67	3.24	1.13	0.17	9.7	8.6	1.35	.288	4.34	103	3.27	107	8.90	-43.6
22	Deacon Phillippe D. Phillippe	828	296	154	90	.631	243	2.50	204	24	7	2158.1	2,071	600	842	27	288	49	47	8,565	42	3.45	1.20	2.88	0.11	9.7	3.4	1.09	.277	3.51	85	2.45	80	8.64	143.9
23	Orval Overall O. Overall	813	184	92	60	.605	152	2.13	116	25	11	1322.2	1,053	313	443	13	471	43	28	5,295	52	5.53	3.20	1.73	0.09	15.4	8.9	1.15	.263	3.01	78	2.35	84	7.17	63.1
24	Mordecai Brown M. Brown	799	246	144	65	.689	195	1.63	170	41	19	1827.2	1,443	331	517	16	356	35	49	7,000	34	3.93	1.75	2.24	0.08	11.4	5.1	0.98	.246	2.55	61	2.22	80	7.11	103.8
25	Chick Fraser C. Fraser	792	288	118	134	.468	251	3.29	219	17	5	2204.2	2,175	805	1,155	42	836	117	34	9,342	72	3.23	3.41	0.95	0.17	8.5	8.9	1.37	.282	4.71	108	3.40	110	8.88	-72.2