5 players were tied for the most strikeouts in a game in 2022, with 5 strikeouts. The first three are Jonathan India on September 11, 2022, Tyler Naquin on August 19, 2022 and C.J. Cron on July 22, 2022.

Interpreted as:

most strikeouts by a player in one regular-season game 2022

	NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Jonathan India J. India	5	9/11/2022	CIN	@	MIL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
2	Tyler Naquin T. Naquin	5	8/19/2022	NYM	@	PHI	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
3	C.J. Cron	5	7/22/2022	COL	@	MIL	6	0	1	0	0	0	0	0	0	0	0	6	1	0	0	0	0	0
4	Curt Casali C. Casali	5	6/3/2022	SFG	@	MIA	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
5	Bryson Stott B. Stott	5	4/16/2022	PHI	@	MIA	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
6	Bradley Zimmer B. Zimmer	4	10/5/2022	TOR	@	BAL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
7	Drew Waters D. Waters	4	10/5/2022	KCR	@	CLE	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
8	Michael Toglia M. Toglia	4	10/5/2022	COL	@	LAD	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
9	Lane Thomas L. Thomas	4	10/4/2022	WSH	@	NYM	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
10	Austin Riley A. Riley	4	10/3/2022	ATL	@	MIA	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
11	Bo Naylor B. Naylor	4	10/2/2022	CLE	vs	KCR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
12	Gunnar Henderson G. Henderson	4	10/1/2022	BAL	@	NYY	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
13	Patrick Wisdom P. Wisdom	4	10/1/2022	CHC	vs	CIN	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
14	Jo Adell J. Adell	4	9/29/2022	LAA	vs	OAK	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
15	Ryan Mountcastle R. Mountcastle	4	9/28/2022	BAL	@	BOS	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
16	Jon Berti J. Berti	4	9/28/2022	MIA	@	NYM	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
17	Pete Alonso P. Alonso	4	9/28/2022	NYM	vs	MIA	4	1	0	0	0	0	0	1	0	0	0	5	0	0	0	0	0	0
18	Joey Gallo J. Gallo	4	9/28/2022	LAD	@	SDP	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
19	Giancarlo Stanton G. Stanton	4	9/27/2022	NYY	@	TOR	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
20	Gunnar Henderson G. Henderson	4	9/25/2022	BAL	vs	HOU	4	0	0	0	0	0	0	1	0	0	0	5	0	0	0	0	0	0
21	Austin Riley A. Riley	4	9/25/2022	ATL	@	PHI	6	0	1	0	0	0	0	0	0	0	0	6	1	0	0	0	0	0
22	Vladimir Guerrero Jr. V. Guerrero Jr.	4	9/23/2022	TOR	@	TBR	5	0	1	0	0	0	1	0	0	0	0	5	1	0	0	0	0	0
23	JJ Bleday	4	9/21/2022	MIA	vs	CHC	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
24	Josh Jung J. Jung	4	9/21/2022	TEX	vs	LAA	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
25	Austin Slater A. Slater	4	9/21/2022	SFG	@	COL	5	0	1	0	0	0	0	0	0	0	0	5	1	0	0	0	0	0