Roger Clemens has struck out the most career batters, with 4,672 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Roger Clemens R. Clemens	4,672	709	354	184	.658	707	3.12	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
2	Justin Verlander J. Verlander	3,457	536	262	150	.636	536	3.31	26	9	0	3467.2	2,943	1,277	1,381	363	973	116	0	27	14,170	97	8.97	2.53	3.55	0.94	24.4	6.9	1.13	.279	3.58	78	3.43	81	7.64	303.2
3	Max Scherzer M. Scherzer	3,408	467	215	112	.657	458	3.16	12	5	0	2881.0	2,349	1,012	1,085	337	756	112	2	20	11,640	78	10.65	2.36	4.51	1.05	29.3	6.5	1.08	.286	3.39	76	3.18	77	7.34	307.9
4	Curt Schilling C. Schilling	3,116	569	216	146	.597	436	3.46	83	20	22	3261.0	2,998	1,253	1,318	347	711	52	81	43	13,284	72	8.60	1.96	4.38	0.96	23.5	5.4	1.14	.293	3.64	80	3.22	76	8.27	373.6
5	CC Sabathia	3,093	561	251	161	.609	560	3.74	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
6	Zack Greinke Z. Greinke	2,979	586	225	156	.591	541	3.49	17	5	1	3389.1	3,207	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
7	Clayton Kershaw C. Kershaw	2,970	433	212	94	.693	430	2.51	25	15	0	2746.2	2,096	767	840	228	681	44	1	28	10,836	103	9.73	2.23	4.36	0.75	27.4	6.3	1.01	.270	2.75	64	2.83	70	6.87	365.3
8	Mickey Lolich M. Lolich	2,832	586	217	191	.532	496	3.44	195	41	10	3638.1	3,366	1,390	1,537	347	1,099	92	40	67	15,140	124	7.01	2.72	2.58	0.86	18.7	7.3	1.23	.280	3.80	96	3.19	87	8.33	188.5
9	Frank Tanana F. Tanana	2,773	638	240	236	.504	616	3.66	143	34	1	4188.1	4,063	1,704	1,910	448	1,255	129	10	116	17,641	119	5.96	2.70	2.21	0.96	15.7	7.1	1.27	.277	4.10	94	3.78	96	8.73	66.4
10	David Cone D. Cone	2,668	450	194	126	.606	419	3.46	56	22	1	2898.2	2,504	1,115	1,222	258	1,137	106	9	42	12,184	149	8.28	3.53	2.35	0.80	21.9	9.3	1.26	.280	3.79	84	3.56	85	7.77	190.9
11	Chuck Finley C. Finley	2,610	524	200	173	.536	467	3.85	63	15	0	3197.1	3,069	1,366	1,517	304	1,332	76	24	36	13,638	130	7.35	3.75	1.96	0.86	19.1	9.8	1.38	.297	4.27	87	3.90	88	8.64	189.7
12	Cole Hamels C. Hamels	2,560	423	163	122	.572	422	3.43	17	7	0	2698.0	2,424	1,027	1,103	310	767	100	0	43	11,115	57	8.54	2.56	3.34	1.03	23.0	6.9	1.18	.287	3.68	82	3.68	88	8.09	151.3
13	Jerry Koosman J. Koosman	2,556	612	222	209	.515	527	3.36	140	33	17	3839.1	3,635	1,433	1,608	290	1,198	71	43	121	15,996	89	5.99	2.81	2.13	0.68	16.0	7.5	1.26	.282	3.77	92	3.25	90	8.52	152.5
14	Javier Vazquez J. Vazquez	2,536	450	165	160	.508	443	4.22	28	8	0	2840.0	2,784	1,331	1,431	373	763	88	5	58	11,935	76	8.04	2.42	3.32	1.18	21.2	6.4	1.25	.295	4.53	96	3.90	88	8.82	164.4
15	Bartolo Colon B. Colon	2,535	565	247	188	.568	552	4.12	38	13	0	3461.2	3,593	1,584	1,719	439	948	64	2	47	14,655	45	6.59	2.46	2.67	1.14	17.3	6.5	1.31	.296	4.47	95	4.14	96	9.34	71.6
16	Felix Hernandez F. Hernandez	2,524	419	169	136	.554	418	3.42	25	11	0	2729.2	2,487	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
17	A.J. Burnett	2,513	435	164	157	.511	430	3.99	24	10	0	2731.1	2,519	1,210	1,328	263	1,100	143	1	35	11,665	161	8.28	3.62	2.28	0.87	21.5	9.4	1.32	.295	4.38	97	3.86	92	8.30	97.3
18	Jon Lester J. Lester	2,488	452	200	117	.631	451	3.66	15	4	0	2740.0	2,610	1,114	1,215	294	892	90	0	13	11,487	63	8.17	2.93	2.79	0.97	21.7	7.8	1.28	.300	3.99	86	3.77	92	8.57	101.7
19	Chris Sale C. Sale	2,486	382	140	86	.619	302	3.05	16	3	12	2013.0	1,649	683	736	208	470	124	25	15	8,116	47	11.11	2.10	5.29	0.93	30.6	5.8	1.05	.298	3.29	72	2.89	69	7.37	289.6
20	Mark Langston M. Langston	2,464	457	179	158	.531	428	3.97	81	18	0	2962.2	2,723	1,306	1,438	311	1,289	46	3	34	12,562	89	7.49	3.92	1.91	0.94	19.6	10.3	1.35	.285	4.37	93	3.93	91	8.27	120.6
21	Sam McDowell S. McDowell	2,453	425	141	134	.513	346	3.17	103	23	14	2492.1	1,948	879	999	164	1,312	59	39	74	10,587	140	8.86	4.74	1.87	0.59	23.2	12.4	1.31	.270	3.61	90	3.06	84	7.03	160.4
22	Andy Pettitte A. Pettitte	2,448	531	256	153	.626	521	3.85	26	4	0	3316.0	3,448	1,418	1,572	288	1,031	55	3	42	14,074	69	6.64	2.80	2.37	0.78	17.4	7.3	1.35	.308	4.27	86	3.73	83	9.36	282.1
23	Jamie Moyer J. Moyer	2,441	696	269	209	.563	638	4.25	33	10	0	4074.0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	97	4.46	102	9.35	-33.5
24	Luis Tiant L. Tiant	2,416	573	229	172	.571	484	3.30	187	49	15	3486.1	3,075	1,280	1,400	346	1,104	49	51	53	14,365	27	6.24	2.85	2.19	0.89	16.8	7.7	1.20	.261	3.61	87	3.46	92	7.94	117.1
25	Kevin Brown K. Brown	2,397	486	211	144	.594	476	3.28	72	17	0	3256.1	3,079	1,185	1,357	208	901	139	1	42	13,542	108	6.62	2.49	2.66	0.57	17.7	6.7	1.22	.290	3.75	78	3.32	78	8.51	344.2