Walter Johnson has fanned the most career hitters against the Yankees, with 521 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Walter Johnson W. Johnson	521	108	61	38	.616	94	1.61	78	21	3	846.1	687		261	23	209	30	14			31	5.54	2.22	2.49	0.24		6.2	1.06	.256	2.78	7.31
2	Lefty Grove L. Grove	390	92	34	26	.567	69	3.84	39	4	8	553.1	568	236	280	41	216	3	17		2,407	12	6.34	3.51	1.81	0.67	16.2	9.0	1.42	.300	4.55	9.24
3	Bob Feller B. Feller	373	79	30	37	.448	73	4.00	34	3	2	555.2	501	247	269	50	280	12	4	0	2,413	17	6.04	4.54	1.33	0.81	15.5	11.6	1.41	.266	4.36	8.11
4	Early Wynn E. Wynn	372	113	33	58	.363	99	4.22	42	6	2	733.1	713	344	385	84	305	8	11	8	3,174	9	4.57	3.74	1.22	1.03	11.7	9.6	1.39	.262	4.73	8.75
5	Billy Pierce B. Pierce	313	89	25	37	.403	77	3.94	27	4	4	532.1	526	233	265	48	174	5	8		2,268	6	5.29	2.94	1.80	0.81	13.8	7.7	1.31	.277	4.48	8.89
6	Camilo Pascual C. Pascual	296	69	20	27	.426	56	3.98	18	6	1	391.2	370	173	188	51	147	3	7	12	1,669	13	6.80	3.38	2.01	1.17	17.7	8.8	1.32	.272	4.32	8.50
7	Mickey Lolich M. Lolich	287	63	23	29	.442	55	3.60	25	4	2	402.1	391	161	187	51	107	9	4	10	1,689	14	6.42	2.39	2.68	1.14	17.0	6.3	1.24	.275	4.18	8.75
8	Bobo Newsom B. Newsom	281	73	24	35	.407	65	4.99	30	1	1	474.1	508	263	292	45	260	11	4		2,163	7	5.33	4.93	1.08	0.85	13.0	12.0	1.62	.296	5.54	9.64
9	Hal Newhouser H. Newhouser	278	81	33	31	.516	65	4.01	32	1	2	493.2	463	220	242	41	212	4	11	0	2,115	8	5.07	3.86	1.31	0.75	13.1	10.0	1.37	.267	4.41	8.44
10	Ed Walsh E. Walsh	276	77	38	19	.667	53	0.35	43	5	6	521.1	401		151	3	130	9	22			19	4.76	2.24	2.12	0.05		7.0	1.02	.276	2.61	6.92
11	Chief Bender C. Bender	264	68	32	19	.627	53	0.83	43	8	6	468.1	402		158	6	112	18	13			6	5.07	2.15	2.36	0.12		6.3	1.10	.287	3.04	7.73
12	Pedro Martinez P. Martinez	261	32	11	11	.500	32	3.20	4	1	0	216.2	170	77	79	17	63	17	0	2	894	9	10.84	2.62	4.14	0.71	29.2	7.0	1.08	.285	3.28	7.06
13	Roger Clemens R. Clemens	260	38	18	13	.581	38	3.78	8	3	0	267.0	246	112	126	15	97	10	0	2	1,125	5	8.76	3.27	2.68	0.51	23.1	8.6	1.28	.311	4.25	8.29
14	Red Faber R. Faber	260	103	33	32	.508	71	3.27	39	4	10	605.1	579	220	273	32	218	17	29		2,565	8	3.87	3.24	1.19	0.48	10.1	8.5	1.32	.268	4.06	8.61
15	Sam McDowell S. McDowell	254	38	17	11	.607	34	2.53	16	3	3	260.0	211	73	84	14	118	6	4	6	1,091	10	8.79	4.08	2.15	0.48	23.3	10.8	1.27	.282	2.91	7.30
16	Eddie Cicotte E. Cicotte	249	81	35	24	.593	60	1.63	38	6	5	530.1	462		198	8	151	6	15		2,142	9	4.23	2.56	1.65	0.14	11.6	7.0	1.16	.263	3.36	7.84
17	Earl Whitehill E. Whitehill	228	84	29	34	.460	78	5.08	28	1	1	553.0	623	312	363	58	266	19	4		2,505	8	3.71	4.33	0.86	0.94	9.1	10.6	1.61	.292	5.91	10.14
18	Luis Tiant L. Tiant	227	53	22	15	.595	44	2.84	20	7	3	341.2	279	108	117	29	112	4	8	7	1,398	3	5.98	2.95	2.03	0.76	16.2	8.0	1.14	.244	3.08	7.35
19	Frank Tanana F. Tanana	224	55	20	19	.513	52	3.70	7	2	1	343.0	348	141	154	34	106	11	2	12	1,464	11	5.88	2.78	2.11	0.89	15.3	7.2	1.32	.288	4.04	9.13
20	David Price D. Price	222	44	16	15	.516	43	5.04	0	0	0	259.0	285	145	151	38	84	6	0	3	1,129	5	7.71	2.92	2.64	1.32	19.7	7.4	1.42	.317	5.25	9.90
21	Bert Blyleven B. Blyleven	215	40	13	19	.406	40	3.56	15	3	0	291.0	303	115	131	28	81	10	0	4	1,225	10	6.65	2.51	2.65	0.87	17.6	6.6	1.32	.309	4.05	9.37
22	George Uhle G. Uhle	213	82	27	25	.519	56	4.01	34	6	5	471.1	504		251	35	168	11	21		2,044	13	4.07	3.21	1.27	0.67	10.4	8.2	1.43	.290	4.79	9.62
23	Chuck Finley C. Finley	206	40	17	10	.630	35	3.82	4	1	0	238.0	232	101	107	22	109	8	1	4	1,035	14	7.79	4.12	1.89	0.83	19.9	10.5	1.43	.304	4.05	8.77
24	Frank Lary F. Lary	205	56	28	13	.683	49	3.32	24	3	2	371.2	361	137	154	45	113	14	3		1,566	10	4.96	2.74	1.81	1.09	13.1	7.2	1.28	.266	3.73	8.74
25	Rube Walberg R. Walberg	205	104	20	26	.435	50	4.71	21	2	5	428.1	443	224	247	55	194	2	28		1,885	6	4.31	4.08	1.06	1.16	10.9	10.3	1.49	.272	5.19	9.31