The Colorado Rockies put up the most runs by a team in April 2001, with 161 runs.

	TEAM	R	MONTH	G	W%	W	L	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	161	April 2001	24	.542	13	11	841	260	53	8	41	154	80	8	158	15	7	956	452	102	16	11	10	11	.309	.370	.537	.908
2	Rangers	151	April 2001	25	.440	11	14	879	253	62	2	41	145	93	16	188	16	7	1,003	442	105	4	11	5	18	.288	.362	.503	.865
3	Diamondbacks	148	April 2001	25	.520	13	12	839	225	39	6	44	140	89	14	157	7	6	955	408	89	10	3	2	26	.268	.347	.486	.833
4	Blue Jays	143	April 2001	25	.640	16	9	895	238	39	4	36	137	100	13	166	15	5	1,021	393	79	5	8	9	17	.266	.345	.439	.785
5	Mariners	138	April 2001	25	.800	20	5	870	239	44	3	23	131	109	4	150	16	4	1,002	358	70	6	13	15	20	.275	.353	.411	.765
6	Red Sox	134	April 2001	25	.640	16	9	889	246	55	5	30	130	79	10	178	6	3	990	401	90	5	7	7	16	.277	.340	.451	.791
7	Yankees	131	April 2001	26	.538	14	12	935	260	44	2	32	126	78	5	159	31	10	1,032	404	78	5	9	5	16	.278	.334	.432	.766
8	Astros	129	April 2001	24	.500	12	12	821	225	40	5	38	124	98	16	169	9	8	950	389	83	8	7	6	19	.274	.360	.474	.834
9	Indians	129	April 2001	23	.609	14	9	798	226	45	3	24	124	84	13	136	11	7	909	349	72	7	7	6	13	.283	.358	.437	.795
10	Padres	128	April 2001	25	.400	10	15	863	225	48	7	18	121	110	11	198	20	8	999	341	73	6	9	5	17	.261	.348	.395	.744
11	Brewers	128	April 2001	24	.542	13	11	793	218	30	6	39	121	84	9	195	9	11	905	377	75	13	6	14	19	.275	.349	.475	.824
12	Twins	126	April 2001	24	.750	18	6	804	213	49	11	28	118	77	8	137	21	6	906	368	88	9	8	9	11	.265	.332	.458	.790
13	Reds	126	April 2001	24	.583	14	10	845	248	42	6	20	122	74	12	172	25	8	947	362	68	12	4	14	26	.293	.357	.428	.786
14	Cardinals	124	April 2001	24	.500	12	12	823	226	36	7	37	119	73	13	200	10	12	926	387	80	11	6	5	23	.275	.341	.470	.811
15	Dodgers	121	April 2001	25	.600	15	10	825	205	41	7	34	111	77	7	180	16	5	927	362	82	12	6	5	13	.248	.316	.439	.755
16	Marlins	119	April 2001	24	.417	10	14	827	216	51	2	35	114	86	6	189	26	5	935	376	88	12	4	11	15	.261	.334	.455	.788
17	Royals	115	April 2001	25	.400	10	15	876	218	37	5	27	109	69	6	159	17	4	963	346	69	7	5	2	19	.249	.306	.395	.701
18	Athletics	113	April 2001	25	.320	8	17	861	213	49	2	28	103	102	12	161	10	5	986	350	79	4	7	11	26	.247	.333	.407	.739
19	Giants	111	April 2001	24	.500	12	12	796	196	43	6	32	105	83	6	164	9	5	899	347	81	8	6	9	10	.246	.320	.436	.756
20	Cubs	107	April 2001	24	.625	15	9	785	193	37	3	26	105	87	10	152	9	4	908	314	66	17	9	5	24	.246	.325	.400	.725
21	Braves	102	April 2001	26	.462	12	14	860	204	38	2	27	98	89	7	150	8	5	979	327	67	12	11	5	18	.237	.310	.380	.690
22	White Sox	102	April 2001	23	.348	8	15	801	205	44	6	25	98	61	6	144	21	5	885	336	75	10	7	5	16	.256	.311	.419	.730
23	Phillies	101	April 2001	24	.583	14	10	802	196	35	2	22	94	87	6	185	17	9	914	301	59	11	8	4	15	.244	.320	.375	.695
24	Tigers	98	April 2001	23	.348	8	15	777	200	40	9	21	97	77	8	131	15	11	878	321	70	9	7	3	15	.257	.328	.413	.741
25	Angels	98	April 2001	25	.400	10	15	836	203	38	6	24	96	68	8	169	11	7	920	325	68	3	5	5	18	.243	.304	.389	.693