The New York Yankees had the most runs by a team in a game in 1921, with 21 runs against the Cleveland Indians on September 25, 1921.

Interpreted as:

most team runs in a regular-season game 1921

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Yankees	21	9/25/1921	NYY	vs	CLE	W 21-7	44	20	1	2	2	19	8	0	3	1	0	52	31	5	0	.455	.538	.705	1.243
2	White Sox	20	9/9/1921	CWS	vs	DET	W 20-15	43	22	2	4	1	18	3	0	4	1	2	48	35	7	2	.512	.543	.814	1.357
3	Yankees	19	9/10/1921	NYY	@	PHA	W 19-3	46	24	4	1	0	17	7	0	3	1	2	57	30	5	4	.522	.585	.652	1.237
4	Cubs	19	5/11/1921	CHC	@	PHN	W 19-8	45	21	8	0	0	19	4	1	2	2	2	50	29	8	0	.467	.520	.644	1.164
5	White Sox	18	9/24/1921	CWS	@	PHA	W 18-1	44	17	5	1	1	16	8	1	6	3	1	54	27	7	1	.386	.491	.614	1.104
6	Tigers	18	7/29/1921	DET	@	PHA	W 18-6	41	19	3	0	2	15	4	1	1	2	1	49	28	5	3	.463	.522	.683	1.205
7	Indians	18	4/28/1921	CLE	vs	DET	W 18-5	45	23	5	1	1	18	7	2	1	0	0	54	33	7	0	.511	.593	.733	1.326
8	Indians	17	9/15/1921	CLE	@	PHA	W 17-3	38	15	3	2	1	15	16	0	4	5	0	57	25	6	3	.395	.574	.658	1.232
9	Yankees	17	8/31/1921	NYY	@	WSH	W 17-9	44	21	1	3	1	15	4	0	1	0	3	49	31	5	1	.477	.521	.705	1.225
10	Indians	17	7/21/1921	CLE	vs	NYY	W 17-8	45	22	9	0	0	15	5	1	2	0	0	52	31	9	1	.489	.549	.689	1.238
11	Giants	17	6/25/1921	NYG	@	PHN	W 17-4	43	16	2	0	5	16	5	0	3	6	1	48	33	7	0	.372	.438	.767	1.205
12	Cardinals	17	6/21/1921	SLN	vs	CHC	W 17-5	32	14	3	0	2	14	11	0	1	1	1	47	23	5	4	.438	.581	.719	1.300
13	Tigers	17	5/16/1921	DET	vs	WSH	W 17-11	39	20	3	4	1	16	5	0	1	1	0	45	34	8	1	.513	.568	.872	1.440
14	Indians	17	5/8/1921	CLE	vs	CWS	W 17-3	42	20	6	2	0	17	4	0	3	1	0	47	30	8	1	.476	.522	.714	1.236
15	Senators	16	8/8/1921	WSH	vs	SLA	W 16-5	39	17	4	1	0	12	3	2	5	0	1	47	23	5	3	.436	.500	.590	1.090
16	Indians	16	7/30/1921	CLE	@	NYY	W 16-1	41	18	3	1	1	15	4	0	6	0	1	49	26	5	4	.439	.489	.634	1.123
17	Indians	16	7/5/1921	CLE	vs	CWS	W 16-4	32	13	1	3	0	14	9	1	1	2	1	47	20	4	5	.406	.548	.625	1.173
18	Braves	16	6/21/1921	BSN	@	NYG	W 16-5	47	18	2	1	3	10	4	0	1	3	1	52	31	6	1	.383	.431	.660	1.091
19	Pirates	16	6/8/1921	PIT	vs	BSN	W 16-4	45	25	5	1	0	12	4	0	1	0	1	50	32	6	1	.556	.592	.711	1.303
20	Indians	16	5/20/1921	CLE	vs	PHA	W 16-3	38	17	4	1	1	15	9	1	3	1	0	51	26	6	3	.447	.563	.684	1.247
21	Red Sox	16	5/13/1921	BSA	@	CWS	W 16-8	41	15	3	0	2	16	8	0	4	3	0	50	24	5	1	.366	.469	.585	1.055
22	Browns	16	5/8/1921	SLA	vs	DET	W 16-8	42	19	3	2	1	11	7	0	4	4	0	50	29	6	1	.452	.531	.690	1.221
23	Browns	15	9/13/1921	SLA	@	WSH	W 15-1	42	15	3	2	0	12	4	1	0	2	1	49	22	5	2	.357	.426	.524	.949
24	Tigers	15	9/9/1921	DET	@	CWS	L 15-20	45	20	1	1	0	13	6	0	2	2	0	53	23	2	2	.444	.510	.511	1.021
25	Tigers	15	9/8/1921	DET	@	CLE	W 15-1	41	20	3	2	0	15	9	0	5	3	1	54	27	5	4	.488	.580	.659	1.239