Lance McCullers Jr. won the most games for the Astros in 2021, with 13 wins.

	NAME	W	SEASON	TM	L	W%	G	GS	ERA	SO	CG	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Lance McCullers Jr. L. McCullers Jr.	13	2021	HOU	5	.722	28	28	3.16	185	0	0	162.1	122	57	59	13	76	10	0	0	684	7	10.26	4.21	2.43	0.72	27.0	11.1	1.22	.273	3.27	74	3.51	83	6.76	13
2	Zack Greinke Z. Greinke	11	2021	HOU	6	.647	30	29	4.16	120	1	0	171.0	164	79	82	30	36	2	0	0	697	3	6.32	1.89	3.33	1.58	17.2	5.2	1.17	.263	4.32	97	4.71	111	8.63	-9.1
3	Framber Valdez F. Valdez	11	2021	HOU	6	.647	22	22	3.14	125	1	0	134.2	110	47	52	12	58	11	0	1	572	9	8.35	3.88	2.16	0.80	21.9	10.1	1.25	.268	3.48	73	4.00	95	7.35	3.4
4	Luis Garcia L. Garcia	11	2021	HOU	8	.579	30	28	3.48	167	0	0	155.1	133	60	62	19	50	3	1	1	633	9	9.68	2.90	3.34	1.10	26.4	7.9	1.18	.289	3.59	81	3.63	86	7.71	10.5
5	José Urquidy J. Urquidy	8	2021	HOU	3	.727	20	20	3.62	90	0	0	107.0	87	43	43	17	19	2	0	0	423	2	7.57	1.60	4.74	1.43	21.3	4.5	0.99	.237	3.62	85	4.13	98	7.32	1.1
6	Jake Odorizzi J. Odorizzi	6	2021	HOU	7	.462	24	23	4.21	91	0	0	104.2	97	49	51	16	34	3	0	1	441	0	7.82	2.92	2.68	1.38	20.6	7.7	1.25	.273	4.39	99	4.47	106	8.34	-2.8
7	Ryan Pressly R. Pressly	5	2021	HOU	3	.625	64	0	2.25	81	0	26	64.0	49	16	19	4	13	0	49	1	250	3	11.39	1.83	6.23	0.56	32.4	5.2	0.97	.296	2.67	53	2.05	48	6.89	15.6
8	Blake Taylor B. Taylor	4	2021	HOU	4	.500	51	0	3.16	41	0	0	42.2	38	15	19	6	22	0	10	2	188	5	8.65	4.64	1.86	1.27	21.8	11.7	1.41	.269	4.01	74	4.62	109	8.02	-1.8
9	Phil Maton P. Maton	4	2021	HOU	0	1.000	27	0	4.97	24	0	0	25.1	29	14	15	2	12	3	2	0	119	0	8.53	4.26	2.00	0.71	20.2	10.1	1.62	.346	5.33	116	4.07	96	10.30	0.5
10	Cristian Javier C. Javier	4	2021	HOU	1	.800	36	9	3.55	130	0	2	101.1	67	40	41	16	53	7	5	1	424	6	11.55	4.71	2.45	1.42	30.7	12.5	1.18	.234	3.64	83	4.43	105	5.95	-2.2
11	Bryan Abreu B. Abreu	3	2021	HOU	3	.500	31	0	5.75	36	0	1	36.0	35	23	26	4	18	3	3	0	161	4	9.00	4.50	2.00	1.00	22.4	11.2	1.47	.310	6.50	134	4.36	103	8.75	-0.5
12	Ryne Stanek R. Stanek	3	2021	HOU	5	.375	72	0	3.42	83	0	2	68.1	46	26	32	8	37	5	13	3	290	6	10.93	4.87	2.24	1.05	28.6	12.8	1.21	.242	4.21	80	4.10	97	6.06	1
13	Brandon Bielak B. Bielak	3	2021	HOU	4	.429	28	2	4.50	46	0	1	50.0	48	25	29	5	21	3	6	0	218	4	8.28	3.78	2.19	0.90	21.1	9.6	1.38	.301	5.22	105	4.06	96	8.64	0.9
14	Brooks Raley B. Raley	2	2021	HOU	3	.400	58	0	4.78	65	0	2	49.0	43	26	30	6	16	3	9	0	205	1	11.94	2.94	4.06	1.10	31.7	7.8	1.20	.322	5.51	112	3.26	77	7.90	5.3
15	Kent Emanuel K. Emanuel	1	2021	HOU	0	1.000	10	0	2.55	13	0	0	17.2	12	5	5	4	4	1	5	0	68	0	6.62	2.04	3.25	2.04	19.1	5.9	0.91	.174	2.55	60	5.48	130	6.11	-2.5
16	Yimi García Y. García	1	2021	HOU	2	.333	23	0	5.48	25	0	0	21.1	18	13	15	3	5	0	8	0	86	0	10.55	2.11	5.00	1.27	29.1	5.8	1.08	.283	6.33	128	3.35	79	7.59	2.1
17	Kendall Graveman K. Graveman	1	2021	HOU	1	.500	23	0	3.13	27	0	0	23.0	20	8	8	1	12	5	3	1	101	1	10.57	4.70	2.25	0.39	26.7	11.9	1.39	.339	3.13	73	3.60	85	7.83	1.6
18	Joe Smith J. Smith	1	2021	HOU	1	.500	27	0	7.48	17	0	0	21.2	35	18	18	4	4	3	10	0	103	2	7.06	1.66	4.25	1.66	16.5	3.9	1.80	.413	7.48	175	4.96	117	14.54	-1.8
19	Peter Solomon P. Solomon	1	2021	HOU	0	1.000	6	0	1.29	10	0	0	14.0	10	2	2	0	8	0	3	0	55	2	6.43	5.14	1.25	0.00	18.2	14.5	1.29	.270	1.29	30	3.45	81	6.43	1.2
20	Ralph Garza R. Garza	1	2021	HOU	2	.333	9	0	4.09	14	0	0	11.0	11	5	6	2	7	0	8	1	49	1	11.45	5.73	2.00	1.64	28.6	14.3	1.64	.346	4.91	96	4.89	115	9.00	-0.8
21	Andre Scrubb A. Scrubb	1	2021	HOU	1	.500	18	0	5.03	21	0	0	19.2	15	11	11	5	14	0	5	0	86	2	9.61	6.41	1.50	2.29	24.4	16.3	1.47	.217	5.03	118	6.47	153	6.86	-4.9