Warren Spahn has the most career wins when allowing 2+ runs, with 203 wins.

Interpreted as:

most regular-season wins by a player by 2 or more runs

	NAME	W	R	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Warren Spahn W. Spahn	203	1,899	230	.469	518	499	4.19	1,755	222	0	0	3642.1	3,836	1,697	403	1,094	35	12	48	15,564	62	4.34	2.70	1.60	1.00	11.3	7.0	1.35	.280	4.69	9.48
2	Grover Alexander G. Alexander	192	1,745	192	.500	448	423	3.40	1,437	266	0	3	3451.2	3,778		150	714	55	14		14,565	30	3.75	1.86	2.01	0.39	9.9	4.9	1.30	.297	4.55	9.85
3	Greg Maddux G. Maddux	178	1,857	220	.447	511	509	4.47	2,197	47	0	0	3310.2	3,666	1,643	329	762	110	2	147	14,182	56	5.97	2.07	2.88	0.89	15.5	5.4	1.34	.309	5.05	9.97
4	Lefty Grove L. Grove	178	1,484	127	.584	384	347	4.11	1,502	198	0	1	2742.2	3,044	1,252	152	892	35	20		12,006	30	4.93	2.93	1.68	0.50	12.5	7.4	1.44	.307	4.87	9.99
5	Steve Carlton S. Carlton	172	2,006	231	.427	523	515	4.42	2,822	129	0	0	3560.0	3,676	1,750	382	1,392	38	2	127	15,449	135	7.13	3.52	2.03	0.97	18.3	9.0	1.42	.305	5.07	9.29
6	Ted Lyons T. Lyons	172	1,978	218	.441	440	401	4.48	890	275	0	3	3286.2	3,898	1,636	207	954	28	25		14,505	52	2.44	2.61	0.93	0.57	6.1	6.6	1.48	.297	5.42	10.67
7	Burleigh Grimes B. Grimes	172	1,964	199	.464	446	405	4.42	1,142	229	0	2	3209.2	3,798	1,575	139	1,054	87	28		14,300	83	3.20	2.96	1.08	0.39	8.0	7.4	1.51	.308	5.51	10.65
8	Christy Mathewson C. Mathewson	171	1,466	170	.501	371	355	1.47	1,481	269	0	0	2954.2	3,110		78	582	43	11			81	4.51	1.77	2.54	0.24		4.8	1.25	.302	4.47	9.47
9	Robin Roberts R. Roberts	170	1,855	227	.428	480	469	4.43	1,678	195	0	0	3395.2	3,756	1,672	468	697	37	5	52	14,424	25	4.45	1.85	2.41	1.24	11.6	4.8	1.31	.285	4.92	9.96
10	Red Ruffing R. Ruffing	170	2,033	209	.449	451	427	4.86	1,417	237	0	2	3258.0	3,636	1,760	240	1,259	48	13		14,453	38	3.91	3.48	1.13	0.66	9.8	8.7	1.50	.296	5.62	10.04
11	Phil Niekro P. Niekro	168	2,201	255	.397	571	546	4.48	2,336	146	0	0	3811.2	4,039	1,896	447	1,391	99	6	73	16,625	178	5.52	3.28	1.68	1.06	14.1	8.4	1.42	.291	5.20	9.54
12	Walter Johnson W. Johnson	164	1,744	242	.404	454	419	2.67	1,942	311	0	3	3488.0	3,524		89	930	143	29			109	5.01	2.40	2.09	0.23		6.3	1.28	.297	4.50	9.09
13	Earl Whitehill E. Whitehill	160	1,970	179	.472	435	416	5.05	1,130	178	0	1	3003.1	3,519	1,686	187	1,272	84	7		13,582	38	3.39	3.81	0.89	0.56	8.3	9.4	1.60	.305	5.90	10.55
14	Eddie Plank E. Plank	159	1,450	178	.472	386	358	2.01	1,371	256	0	6	2826.2	2,954		35	713	135	21			71	4.37	2.27	1.92	0.11		6.5	1.30	.336	4.62	9.41
15	Jim Kaat J. Kaat	157	1,887	212	.425	531	484	4.68	1,686	94	0	0	3089.0	3,583	1,605	361	820	97	14	76	13,549	101	4.91	2.39	2.06	1.05	12.4	6.1	1.43	.304	5.50	10.44
16	Fergie Jenkins F. Jenkins	155	1,743	209	.426	458	439	4.55	2,197	151	0	0	3108.2	3,295	1,570	444	757	63	6	86	13,245	46	6.36	2.19	2.90	1.29	16.6	5.7	1.30	.291	5.05	9.54
17	Early Wynn E. Wynn	155	1,923	229	.404	475	464	4.83	1,581	161	0	1	3152.1	3,476	1,692	312	1,328	48	7	31	14,038	36	4.51	3.79	1.19	0.89	11.3	9.5	1.52	.294	5.49	9.92
18	Jack Morris J. Morris	154	1,743	182	.458	428	417	5.00	1,847	108	0	0	2875.2	3,037	1,596	367	1,124	51	1	88	12,574	173	5.78	3.52	1.64	1.15	14.7	8.9	1.45	.291	5.46	9.50
19	Roger Clemens R. Clemens	152	1,735	178	.461	452	452	4.75	2,750	44	0	0	2979.2	3,078	1,571	330	1,082	115	0	55	12,960	114	8.31	3.27	2.54	1.00	21.2	8.3	1.40	.316	5.24	9.30
20	Gaylord Perry G. Perry	152	1,988	245	.383	525	500	4.34	2,328	160	0	0	3580.1	3,881	1,726	369	1,020	83	8	133	15,378	131	5.85	2.56	2.28	0.93	15.1	6.6	1.37	.303	5.00	9.76
21	Eppa Rixey E. Rixey	152	1,887	231	.397	479	439	4.07	953	188	0	1	3287.2	3,831	1,486	87	854	63	20		14,268	79	2.61	2.34	1.12	0.24	6.7	6.0	1.43	.304	5.17	10.49
22	Jamie Moyer J. Moyer	149	1,971	201	.426	505	491	5.59	1,759	13	0	0	2942.2	3,487	1,829	492	911	110	2	65	13,051	51	5.38	2.79	1.93	1.50	13.5	7.0	1.49	.306	6.03	10.66
23	Don Sutton D. Sutton	149	1,960	242	.381	531	528	4.69	2,323	73	0	0	3421.1	3,599	1,783	427	958	65	1	79	14,706	87	6.11	2.52	2.42	1.12	15.8	6.5	1.33	.290	5.16	9.47
24	Herb Pennock H. Pennock	148	1,620	151	.495	400	341	4.64	890	175	0	4	2612.0	3,294		120	709	24	32		11,589	49	3.07	2.44	1.26	0.41	7.7	6.1	1.53	.322	5.58	11.35
25	Mike Mussina M. Mussina	146	1,468	152	.490	386	385	5.05	1,881	21	0	0	2455.1	2,738	1,378	358	588	50	0	25	10,467	63	6.89	2.16	3.20	1.31	18.0	5.6	1.35	.314	5.38	10.04