Between the 1901 and 1919 seasons, Christy Mathewson won the most games, with 373 wins.

Interpreted as:

most regular-season wins by pitcher from 1901 to 1919

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Christy Mathewson C. Mathewson	373	185	.668	630	551	2.11	2,492	434	79	30	4755.0	4,182	1,116	1,588	88	828	55	69	18,756	114	4.72	1.57	3.01	0.17	13.3	4.4	1.05	.268	3.01	74	2.25	76	7.92	366.3
2	Eddie Plank E. Plank	326	194	.627	623	529	2.35	2,246	410	69	23	4495.2	3,958	1,174	1,566	42	1,072	190	77	17,803	88	4.50	2.15	2.10	0.08	12.6	6.0	1.12	.275	3.14	81	2.45	86	7.92	195.2
3	Walter Johnson W. Johnson	297	191	.609	544	439	1.65	2,614	388	86	22	4090.2	3,145	749	1,103	31	818	142	99	15,736	129	5.75	1.80	3.20	0.07	16.6	5.2	0.97	.257	2.43	60	1.94	70	6.92	384.9
4	Mordecai Brown M. Brown	239	130	.648	481	332	2.06	1,375	271	55	49	3172.1	2,708	725	1,044	43	673	61	138	12,422	61	3.90	1.91	2.04	0.12	11.1	5.4	1.07	.259	2.96	71	2.42	83	7.68	161.9
5	George Mullin G. Mullin	228	196	.538	487	428	2.82	1,482	353	35	8	3686.2	3,518	1,156	1,636	42	1,238	130	51	15,179	85	3.62	3.02	1.20	0.10	9.8	8.2	1.29	.283	3.99	99	2.91	104	8.59	-39
6	Cy Young C. Young	225	146	.606	401	369	2.12	1,563	331	44	9	3312.1	2,900	779	1,119	44	413	73	28	12,717	54	4.25	1.12	3.78	0.12	12.3	3.2	1.00	.269	3.04	74	2.15	76	7.88	252.8
7	Chief Bender C. Bender	212	127	.625	458	334	2.45	1,711	255	40	34	3016.0	2,644	821	1,106	39	711	102	111	11,890	79	5.11	2.12	2.41	0.12	14.4	6.0	1.11	.279	3.30	88	2.29	83	7.89	147.6
8	Grover Alexander G. Alexander	208	100	.675	362	307	2.09	1,539	242	70	16	2753.0	2,300	638	846	49	596	55	50	10,891	20	5.03	1.95	2.58	0.16	14.1	5.5	1.05	.260	2.77	68	2.32	75	7.52	234.9
9	Ed Walsh E. Walsh	195	126	.607	430	315	1.82	1,736	250	57	35	2964.1	2,346	598	873	23	617	52	105	11,413	76	5.27	1.87	2.81	0.07	15.2	5.4	1.00	.259	2.65	69	2.02	79	7.12	164.3
10	Joe McGinnity J. McGinnity	190	118	.617	373	303	2.62	901	244	27	22	2732.0	2,568	795	1,093	44	606	113	59	11,133	22	2.97	2.00	1.49	0.14	8.1	5.4	1.16	.267	3.60	87	2.87	94	8.46	61.8
11	Doc White D. White	189	156	.548	427	363	2.39	1,384	262	45	5	3041.0	2,738	808	1,118	33	670	120	53	12,093	63	4.10	1.98	2.07	0.10	11.4	5.5	1.12	.274	3.31	89	2.51	96	8.10	22.9
12	Eddie Cicotte E. Cicotte	188	138	.577	465	326	2.29	1,287	221	31	22	2922.2	2,581	743	1,033	26	753	50	105	11,506	54	3.96	2.32	1.71	0.08	11.2	6.5	1.14	.272	3.18	81	2.47	88	7.95	116.6
13	Vic Willis V. Willis	187	167	.528	399	366	2.50	1,318	302	42	9	3106.1	2,822	864	1,194	44	841	85	33	12,483	65	3.82	2.44	1.57	0.13	10.6	6.7	1.18	.272	3.46	89	2.69	93	8.18	71.3
14	Red Ames R. Ames	183	167	.523	533	371	2.63	1,702	209	27	36	3198.0	2,896	934	1,313	41	1,034	64	118	13,080	156	4.79	2.91	1.65	0.12	13.0	7.9	1.23	.279	3.70	93	2.54	88	8.15	121.5
15	Ed Reulbach E. Reulbach	182	106	.632	399	300	2.28	1,137	200	40	13	2632.1	2,117	668	887	33	892	107	80	10,521	49	3.89	3.05	1.27	0.11	10.8	8.5	1.14	.250	3.03	80	2.84	99	7.24	9
16	Bill Donovan B. Donovan	182	129	.585	351	314	2.58	1,492	279	35	7	2820.2	2,472	809	1,093	30	959	80	36	11,495	55	4.76	3.06	1.56	0.10	13.0	8.3	1.22	.273	3.49	92	2.69	97	7.89	36.9
17	Rube Waddell R. Waddell	178	127	.584	366	308	2.11	2,137	235	47	4	2659.2	2,198	624	923	30	728	93	45	10,499	70	7.23	2.46	2.94	0.10	20.4	6.9	1.10	.289	3.12	76	1.93	71	7.44	236.6
18	Jack Chesbro J. Chesbro	177	110	.617	341	289	2.52	1,181	225	32	4	2532.0	2,262	708	984	32	552	90	46	10,048	50	4.20	1.96	2.14	0.11	11.8	5.5	1.11	.272	3.50	88	2.49	88	8.04	112.1
19	Jack Powell J. Powell	167	194	.463	423	369	2.76	1,303	294	33	15	3161.1	2,988	969	1,329	76	685	77	49	12,679	52	3.71	1.95	1.90	0.22	10.3	5.4	1.16	.276	3.78	96	2.74	98	8.51	16.4
20	Earl Moore E. Moore	163	154	.514	388	326	2.78	1,403	230	34	6	2776.0	2,474	856	1,231	57	1,108	106	46	11,507	78	4.55	3.59	1.27	0.18	12.2	9.6	1.29	.274	3.99	90	3.13	102	8.02	-20.5
21	Slim Sallee S. Sallee	162	133	.549	413	291	2.50	798	182	25	32	2592.1	2,469	719	980	57	543	41	97	10,522	12	2.77	1.89	1.47	0.20	7.6	5.2	1.16	.266	3.40	88	2.80	96	8.57	30.6
22	Addie Joss A. Joss	160	97	.623	286	260	1.89	920	234	45	5	2327.0	1,888	488	730	19	364	58	22	8,891	28	3.56	1.41	2.53	0.07	10.3	4.1	0.97	.248	2.82	70	2.25	86	7.30	88.8
23	Jack Coombs J. Coombs	158	110	.590	352	268	2.78	1,051	187	35	8	2314.1	2,027	715	920	38	839	88	68	9,435	54	4.09	3.26	1.25	0.15	11.1	8.9	1.24	.268	3.58	99	2.92	108	7.88	-58.5
24	Sam Leever S. Leever	157	64	.710	302	228	2.31	627	179	32	10	2016.0	1,834	518	721	20	412	68	61	8,016	28	2.80	1.84	1.52	0.09	7.8	5.1	1.11	.263	3.22	82	2.70	93	8.19	45.7
25	Hippo Vaughn H. Vaughn	156	110	.586	333	280	2.31	1,255	183	37	5	2319.2	2,007	596	836	23	705	72	41	9,470	59	4.87	2.74	1.78	0.09	13.3	7.4	1.17	.268	3.24	79	2.47	85	7.79	110.1