Jesse Crain won the most games by a relief pitcher in 2005, with 12 wins in his rookie season.

	NAME	W	SEASON	TM	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Jesse Crain J. Crain	12	2005	MIN	5	.706	75	0	2.71	25	0	0	1	79.2	61	24	28	6	29	5	17	7	326	2	2.82	3.28	0.86	0.68	7.7	8.9	1.13	.211	3.16	6.89
2	Scot Shields S. Shields	10	2005	LAA	11	.476	78	0	2.75	98	0	0	7	91.2	66	28	33	5	37	2	21	2	375	12	9.62	3.63	2.65	0.49	26.1	9.9	1.12	.262	3.24	6.48
3	Brendan Donnelly B. Donnelly	9	2005	LAA	3	.750	65	0	3.72	53	0	0	0	65.1	60	27	30	9	19	2	14	3	271	3	7.30	2.62	2.79	1.24	19.6	7.0	1.21	.271	4.13	8.27
4	Roberto Hernandez R. Hernandez	8	2005	NYM	6	.571	67	0	2.58	61	0	0	4	69.2	57	20	20	5	28	2	20	4	291	4	7.88	3.62	2.18	0.65	21.0	9.6	1.22	.267	2.58	7.36
5	Luis Ayala L. Ayala	8	2005	WSH	7	.533	68	0	2.66	40	0	0	1	71.0	75	21	23	7	14	6	18	4	293	0	5.07	1.77	2.86	0.89	13.7	4.8	1.25	.301	2.92	9.51
6	Scott Linebrink S. Linebrink	8	2005	SDP	1	.889	73	0	1.83	70	0	0	1	73.2	55	15	17	4	23	0	17	4	288	3	8.55	2.81	3.04	0.49	24.3	8.0	1.06	.267	2.08	6.72
7	Lance Cormier L. Cormier	7	2005	ARI	3	.700	67	0	5.11	63	0	0	0	79.1	86	45	50	7	43	5	13	5	356	6	7.15	4.88	1.47	0.79	17.7	12.1	1.63	.332	5.67	9.76
8	Derrick Turnbow D. Turnbow	7	2005	MIL	1	.875	69	0	1.74	64	0	0	39	67.1	49	13	15	5	24	1	62	2	271	9	8.55	3.21	2.67	0.67	23.6	8.9	1.08	.249	2.00	6.55
9	Bob Howry B. Howry	7	2005	CLE	4	.636	79	0	2.47	48	0	0	3	73.0	49	20	23	4	16	0	24	1	277	0	5.92	1.97	3.00	0.49	17.3	5.8	0.89	.215	2.84	6.04
10	Cliff Politte C. Politte	7	2005	CWS	1	.875	68	0	2.00	57	0	0	1	67.1	42	15	15	7	21	3	14	4	262	1	7.62	2.81	2.71	0.94	21.8	8.0	0.94	.201	2.00	5.61
11	Giovanni Carrara G. Carrara	7	2005	LAD	4	.636	72	0	3.93	56	0	0	0	75.2	65	33	35	6	38	6	18	5	326	4	6.66	4.52	1.47	0.71	17.2	11.7	1.36	.268	4.16	7.73
12	Joe Nathan J. Nathan	7	2005	MIN	4	.636	69	0	2.70	94	0	0	43	70.0	46	21	22	5	22	0	58	1	276	2	12.09	2.83	4.27	0.64	34.1	8.0	0.97	.265	2.83	5.91
13	Mariano Rivera M. Rivera	7	2005	NYY	4	.636	71	0	1.38	80	0	0	43	78.1	50	12	18	2	18	4	67	0	306	0	9.19	2.07	4.44	0.23	26.1	5.9	0.87	.238	2.07	5.74
14	Justin Duchscherer J. Duchscherer	7	2005	OAK	4	.636	65	0	2.21	85	0	0	5	85.2	67	21	25	7	19	2	24	3	338	2	8.93	2.00	4.47	0.74	25.1	5.6	1.00	.267	2.63	7.04
15	Rudy Seanez R. Seanez	7	2005	SDP	1	.875	57	0	2.69	84	0	0	0	60.1	49	18	19	4	22	2	9	4	248	4	12.53	3.28	3.82	0.60	33.9	8.9	1.18	.331	2.83	7.31
16	David Weathers D. Weathers	7	2005	CIN	4	.636	73	0	3.94	61	0	0	15	77.2	71	34	36	7	29	2	41	2	331	4	7.07	3.36	2.10	0.81	18.4	8.8	1.29	.276	4.17	8.23
17	Mike Timlin M. Timlin	7	2005	BOS	3	.700	81	0	2.24	59	0	0	13	80.1	86	20	23	2	20	2	27	5	342	3	6.61	2.24	2.95	0.22	17.3	5.8	1.32	.324	2.58	9.63
18	Jason Christiansen J. Christiansen	6	2005	TOT	1	.857	68	0	5.12	21	0	0	0	45.2	55	26	28	4	17	0	11	2	208	0	4.14	3.35	1.24	0.79	10.1	8.2	1.58	.307	5.52	10.84
19	Chad Qualls C. Qualls	6	2005	HOU	4	.600	77	0	3.28	60	0	0	0	79.2	73	29	33	7	23	6	19	2	329	1	6.78	2.60	2.61	0.79	18.2	7.0	1.21	.283	3.73	8.25
20	Luis Vizcaino L. Vizcaino	6	2005	CWS	5	.545	65	0	3.73	43	0	0	0	70.0	74	29	30	8	29	2	20	6	305	3	5.53	3.73	1.48	1.03	14.1	9.5	1.47	.296	3.86	9.51
21	Tyler Walker T. Walker	6	2005	SFG	4	.600	67	0	4.23	54	0	0	23	61.2	68	29	31	9	27	3	39	6	279	4	7.88	3.94	2.00	1.31	19.4	9.7	1.54	.317	4.52	9.92
22	J.J. Putz	6	2005	SEA	5	.545	64	0	3.60	45	0	0	1	60.0	58	24	27	8	23	2	20	2	259	2	6.75	3.45	1.96	1.20	17.4	8.9	1.35	.276	4.05	8.70
23	Juan Rincon J. Rincon	6	2005	MIN	6	.500	75	0	2.45	84	0	0	0	77.0	63	21	26	2	30	3	18	3	319	5	9.82	3.51	2.80	0.23	26.3	9.4	1.21	.305	3.04	7.36
24	Michael Wuertz M. Wuertz	6	2005	CHC	2	.750	75	0	3.81	89	0	0	0	75.2	60	32	36	6	40	0	12	7	319	7	10.59	4.76	2.23	0.71	27.9	12.5	1.32	.293	4.28	7.14
25	Ryan Madson R. Madson	6	2005	PHI	5	.545	78	0	4.14	79	0	0	0	87.0	84	40	44	11	25	6	10	6	365	6	8.17	2.59	3.16	1.14	21.6	6.8	1.25	.299	4.55	8.69