Walter Johnson has won the most career games by a starting pitcher, with 376 wins.

Interpreted as:

most regular-season wins by starting pitcher ever

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Walter Johnson W. Johnson	376	249	.602	666	666	1.69	3,273	531	110	0	5552.0	4,610		1,766	90	1,295	191	0			144	5.31	2.10	2.53	0.15		5.8	1.06	.261	2.86	7.47
2	Warren Spahn W. Spahn	358	227	.612	665	665	3.08	2,501	382	63	0	5101.0	4,703	1,743	1,951	422	1,383	39	0	52	20,960	74	4.41	2.44	1.81	0.74	11.9	6.6	1.19	.258	3.44	8.30
3	Greg Maddux G. Maddux	355	226	.611	740	740	3.15	3,366	109	35	0	5001.0	4,717	1,750	1,974	351	996	137	0	177	20,388	70	6.06	1.79	3.38	0.63	16.5	4.9	1.14	.281	3.55	8.49
4	Roger Clemens R. Clemens	354	184	.658	707	707	3.12	4,671	118	46	0	4913.2	4,182	1,706	1,884	363	1,579	159	0	63	20,227	143	8.56	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	7.66
5	Grover Alexander G. Alexander	350	193	.645	600	600	2.37	2,096	437	90	0	4978.1	4,654		1,742	156	887	66	0		20,045	33	3.79	1.60	2.36	0.28	10.5	4.4	1.11	.267	3.15	8.41
6	Christy Mathewson C. Mathewson	343	177	.660	551	551	0.96	2,408	434	79	0	4540.0	4,018		1,513	82	801	51	0			107	4.77	1.59	3.01	0.16		4.5	1.06	.269	3.00	7.97
7	Steve Carlton S. Carlton	327	240	.577	709	709	3.20	4,104	254	55	0	5165.1	4,616	1,835	2,096	405	1,814	53	0	145	21,457	177	7.15	3.16	2.26	0.71	19.1	8.5	1.24	.279	3.65	8.04
8	Don Sutton D. Sutton	321	253	.559	756	756	3.27	3,545	178	58	0	5248.1	4,670	1,905	2,095	469	1,333	81	0	96	21,500	110	6.08	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.59	8.01
9	Nolan Ryan N. Ryan	318	291	.522	773	773	3.18	5,654	222	61	0	5326.0	3,880	1,884	2,151	314	2,748	156	0	75	22,310	275	9.55	4.64	2.06	0.53	25.3	12.3	1.24	.265	3.63	6.56
10	Tom Seaver T. Seaver	310	203	.604	647	647	2.86	3,634	231	61	0	4776.1	3,961	1,517	1,670	378	1,387	76	0	115	19,337	123	6.85	2.61	2.62	0.71	18.8	7.2	1.12	.258	3.15	7.46
11	Tom Glavine T. Glavine	305	203	.600	682	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	8.76
12	Gaylord Perry G. Perry	305	252	.548	690	690	3.10	3,372	303	53	0	5156.2	4,762	1,778	2,045	382	1,314	101	0	144	21,140	150	5.89	2.29	2.57	0.67	16.0	6.2	1.18	.274	3.57	8.31
13	Phil Niekro P. Niekro	302	262	.535	716	716	3.37	3,181	245	45	0	5149.2	4,815	1,928	2,227	465	1,703	116	0	73	21,585	207	5.56	2.98	1.87	0.81	14.7	7.9	1.27	.270	3.89	8.42
14	Randy Johnson R. Johnson	301	166	.645	603	603	3.30	4,818	100	37	0	4103.0	3,320	1,504	1,692	408	1,491	188	0	37	16,937	109	10.57	3.27	3.23	0.89	28.4	8.8	1.17	.290	3.71	7.28
15	Eddie Plank E. Plank	299	179	.626	529	529	1.33	2,118	410	69	0	4216.0	3,725		1,458	39	998	179	0			74	4.52	2.13	2.12	0.08		6.2	1.12	.287	3.11	7.95
16	Early Wynn E. Wynn	287	232	.553	611	611	3.56	2,255	289	49	0	4398.2	4,135	1,742	1,981	330	1,713	62	0	32	18,704	50	4.61	3.50	1.32	0.68	12.1	9.2	1.33	.265	4.05	8.46
17	Bert Blyleven B. Blyleven	286	248	.536	685	685	3.31	3,694	242	60	0	4957.1	4,614	1,823	2,021	428	1,316	155	0	67	20,429	114	6.71	2.39	2.81	0.78	18.1	6.4	1.20	.282	3.67	8.38
18	Tommy John T. John	284	228	.555	700	700	3.35	2,191	162	46	0	4622.1	4,699	1,718	1,981	295	1,223	98	0	99	19,321	178	4.27	2.38	1.79	0.57	11.3	6.3	1.28	.284	3.86	9.15
19	Fergie Jenkins F. Jenkins	278	218	.560	594	594	3.32	3,082	267	49	0	4358.2	4,021	1,608	1,786	463	951	83	0	101	17,815	61	6.36	1.96	3.24	0.96	17.3	5.3	1.14	.269	3.69	8.30
20	Robin Roberts R. Roberts	275	240	.534	609	609	3.41	2,292	305	45	0	4567.1	4,467	1,733	1,915	498	872	54	0	63	18,724	32	4.52	1.72	2.63	0.98	12.2	4.7	1.17	.264	3.77	8.80
21	Mike Mussina M. Mussina	270	153	.638	536	536	3.68	2,812	57	23	0	3559.0	3,453	1,456	1,557	376	785	60	0	29	14,576	71	7.11	1.99	3.58	0.95	19.3	5.4	1.19	.292	3.94	8.73
22	Lefty Grove L. Grove	268	119	.693	457	457	3.08	2,013	298	35	0	3560.2	3,513	1,220	1,448	148	1,027	38	0		15,016	38	5.09	2.60	1.96	0.37	13.4	6.8	1.28	.285	3.66	8.88
23	Red Ruffing R. Ruffing	264	212	.555	538	538	3.82	1,869	335	45	0	4132.2	4,094	1,755	2,016	249	1,463	51	0		17,623	44	4.07	3.19	1.28	0.54	10.6	8.3	1.34	.275	4.39	8.92
24	Justin Verlander J. Verlander	262	152	.633	538	538	3.32	3,468	26	9	0	3477.1	2,955	1,283	1,388	364	975	116	0	27	14,213	97	8.98	2.52	3.56	0.94	24.4	6.9	1.13	.279	3.59	7.65
25	Jamie Moyer J. Moyer	262	206	.560	638	638	4.27	2,353	33	10	0	3947.1	4,107	1,872	2,020	509	1,104	142	0	64	16,812	52	5.36	2.52	2.13	1.16	14.0	6.6	1.32	.283	4.61	9.36