Between the 1925 and 1939 seasons, Lefty Grove won the most games, with 286 wins.

Interpreted as:

most regular-season wins by a player from 1925 to 1939

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Lefty Grove L. Grove	286	128	.691	573	415	2.97	2,150	279	34	54	3653.1	3,535	1,206	1,437	134	1,095	39	122	15,372	47	5.30	2.70	1.96	0.33	14.0	7.1	1.27	.285	3.54	66	3.30	74	8.71	459.2
2	Carl Hubbell C. Hubbell	216	121	.641	442	352	2.80	1,424	224	33	32	2988.2	2,827	931	1,094	171	555	48	74	12,225	40	4.29	1.67	2.57	0.51	11.6	4.5	1.13	.265	3.29	70	3.48	86	8.51	183
3	Red Ruffing R. Ruffing	214	191	.528	511	431	3.87	1,686	273	33	18	3514.1	3,492	1,513	1,757	196	1,302	47	66	15,093	40	4.32	3.33	1.29	0.50	11.2	8.6	1.36	.278	4.50	91	3.98	95	8.94	80.5
4	Ted Lyons T. Lyons	207	190	.521	475	392	3.70	820	283	20	22	3325.1	3,588	1,366	1,651	171	925	22	72	14,226	37	2.22	2.50	0.89	0.46	5.8	6.5	1.36	.278	4.47	85	4.10	95	9.71	68.8
5	Earl Whitehill E. Whitehill	199	176	.531	498	438	4.41	1,266	209	14	11	3298.2	3,635	1,616	1,879	182	1,337	85	42	14,616	42	3.45	3.65	0.95	0.50	8.7	9.1	1.51	.294	5.13	100	4.31	99	9.92	7.4
6	Freddie Fitzsimmons F. Fitzsimmons	192	139	.580	470	386	3.54	804	171	25	12	2959.0	3,081	1,164	1,395	172	773	29	60	12,459	56	2.45	2.35	1.04	0.52	6.5	6.2	1.30	.272	4.24	90	4.08	102	9.37	-24.1
7	Wes Ferrell W. Ferrell	191	127	.601	369	320	4.03	971	226	17	13	2605.0	2,828	1,166	1,371	131	1,027	21	41	11,483	34	3.35	3.55	0.95	0.45	8.5	8.9	1.48	.289	4.74	87	4.23	93	9.77	98.8
8	Charlie Root C. Root	191	145	.568	550	316	3.47	1,336	170	21	41	2918.2	2,933	1,124	1,293	167	801	72	157	12,292	20	4.12	2.47	1.67	0.51	10.9	6.5	1.28	.279	3.99	87	3.77	93	9.04	89.4
9	Guy Bush G. Bush	174	131	.570	521	300	3.84	811	147	16	33	2636.0	2,853	1,126	1,311	144	832	39	138	11,376	49	2.77	2.84	0.97	0.49	7.1	7.3	1.40	.284	4.48	95	4.16	102	9.74	-31.1
10	Alvin Crowder A. Crowder	167	115	.592	402	292	4.12	799	150	16	22	2344.1	2,453	1,072	1,204	137	800	16	71	10,070	20	3.07	3.07	1.00	0.53	7.9	7.9	1.39	.278	4.62	95	4.20	98	9.42	23.8
11	Lefty Gomez L. Gomez	165	89	.650	322	278	3.24	1,337	163	26	10	2234.2	2,031	804	949	122	904	15	28	9,505	30	5.38	3.64	1.48	0.49	14.1	9.5	1.31	.268	3.82	75	3.79	90	8.18	98
12	Larry French L. French	163	139	.540	460	317	3.49	950	167	32	15	2604.2	2,831	1,009	1,214	140	672	30	87	11,157	32	3.28	2.32	1.41	0.48	8.5	6.0	1.34	.287	4.19	87	3.87	94	9.78	72.4
13	Mel Harder M. Harder	159	125	.560	419	286	3.81	832	134	16	23	2392.2	2,645	1,014	1,225	107	729	44	90	10,426	22	3.13	2.74	1.14	0.40	8.0	7.0	1.41	.291	4.61	83	3.92	87	9.95	154.4
14	Red Lucas R. Lucas	156	131	.544	366	298	3.68	569	203	22	6	2453.0	2,615	1,003	1,138	131	433	16	52	10,248	7	2.09	1.59	1.31	0.48	5.6	4.2	1.24	.273	4.18	93	3.86	96	9.59	38.6
15	Willis Hudlin W. Hudlin	155	150	.508	471	316	4.33	654	152	11	31	2534.0	2,899	1,220	1,423	105	830	42	100	11,159	40	2.32	2.95	0.79	0.37	5.9	7.4	1.47	.293	5.05	96	4.13	93	10.30	84.6
16	Waite Hoyt W. Hoyt	154	123	.556	475	280	3.67	803	143	16	44	2501.2	2,721	1,021	1,217	118	635	27	130	10,704	25	2.89	2.28	1.26	0.42	7.5	5.9	1.34	.285	4.38	90	3.84	94	9.79	61.8
17	Bump Hadley B. Hadley	153	154	.498	475	342	4.16	1,244	133	14	20	2750.1	2,742	1,272	1,468	149	1,334	60	86	12,094	59	4.07	4.37	0.93	0.49	10.3	11.0	1.48	.279	4.80	94	4.39	101	8.97	-10.4
18	Rube Walberg R. Walberg	151	133	.532	510	294	4.09	1,043	135	15	34	2517.0	2,659	1,144	1,334	153	960	25	134	10,957	38	3.73	3.43	1.09	0.55	9.5	8.8	1.44	.286	4.77	92	4.21	97	9.51	46.6
19	Tommy Bridges T. Bridges	150	102	.595	309	266	3.76	1,207	156	25	8	2083.0	2,015	870	1,021	138	902	29	32	9,033	41	5.22	3.90	1.34	0.60	13.4	10.0	1.40	.278	4.41	81	4.10	91	8.71	93.4
20	Paul Derringer P. Derringer	148	137	.519	375	285	3.50	1,018	163	23	18	2343.2	2,584	911	1,083	93	481	27	68	9,948	40	3.91	1.85	2.12	0.36	10.2	4.8	1.31	.299	4.16	92	3.33	85	9.92	156.7
21	Dizzy Dean D. Dean	147	80	.648	305	219	2.96	1,144	151	26	31	1908.1	1,845	628	736	91	432	27	76	7,903	12	5.40	2.04	2.65	0.43	14.5	5.5	1.19	.282	3.47	75	3.19	78	8.70	192.3
22	Lon Warneke L. Warneke	144	85	.629	318	247	3.23	877	146	24	11	2021.0	1,993	725	845	126	555	21	46	8,471	45	3.91	2.47	1.58	0.56	10.4	6.6	1.26	.271	3.76	83	3.83	96	8.88	35.3
23	Jesse Haines J. Haines	140	85	.622	369	228	3.73	571	126	13	9	1986.0	2,126	823	950	110	548	26	78	8,435	34	2.59	2.48	1.04	0.50	6.8	6.5	1.35	.281	4.31	89	4.09	97	9.63	28.3
24	Pat Malone P. Malone	134	92	.593	357	219	3.74	1,024	114	15	27	1915.0	1,934	795	936	103	705	45	107	8,276	51	4.81	3.31	1.45	0.48	12.4	8.5	1.38	.286	4.40	90	3.92	93	9.09	61.8
25	Firpo Marberry F. Marberry	133	76	.636	490	168	3.71	736	78	7	84	1827.1	1,817	753	867	92	599	26	236	7,733	12	3.62	2.95	1.23	0.45	9.5	7.7	1.32	.275	4.27	87	3.94	94	8.95	50.7