Between the 1927 and 1946 seasons, Lefty Grove won the most games, with 277 wins.

Interpreted as:

most regular-season wins by a player from 1927 to 1946

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Lefty Grove L. Grove	277	116	.705	526	406	3.00	1,956	273	34	47	3485.2	3,415	1,163	1,377	145	955	31	102	14,642	37	5.05	2.47	2.05	0.37	13.4	6.5	1.25	.283	3.56	66	3.32	75	8.82	436.6
2	Red Ruffing R. Ruffing	255	187	.577	533	478	3.66	1,844	315	42	15	3884.2	3,770	1,578	1,828	233	1,373	48	49	16,528	41	4.27	3.18	1.34	0.54	11.2	8.3	1.32	.271	4.24	87	3.91	95	8.73	78.3
3	Carl Hubbell C. Hubbell	253	154	.622	535	433	2.98	1,677	260	36	33	3590.1	3,461	1,188	1,380	227	725	53	82	14,805	53	4.20	1.82	2.31	0.57	11.3	4.9	1.17	.267	3.46	76	3.55	89	8.68	174.2
4	Paul Derringer P. Derringer	223	212	.513	579	445	3.46	1,507	251	32	29	3645.0	3,912	1,401	1,652	158	761	32	98	15,391	50	3.72	1.88	1.98	0.39	9.8	4.9	1.28	.290	4.08	93	3.26	86	9.66	218.5
5	Mel Harder M. Harder	217	182	.544	567	418	3.78	1,144	177	24	24	3346.1	3,615	1,407	1,673	158	1,091	58	94	14,513	33	3.08	2.93	1.05	0.42	7.9	7.5	1.41	.287	4.50	89	3.88	94	9.72	113.6
6	Ted Lyons T. Lyons	207	191	.520	462	398	3.66	919	301	19	17	3375.2	3,638	1,373	1,673	198	845	25	56	14,386	42	2.45	2.25	1.09	0.53	6.4	5.9	1.33	.277	4.46	84	3.99	94	9.70	97.9
7	Larry French L. French	197	171	.535	570	383	3.44	1,187	199	40	17	3152.0	3,375	1,206	1,440	164	819	42	108	13,465	34	3.39	2.34	1.45	0.47	8.8	6.1	1.33	.285	4.11	87	3.76	93	9.64	101.2
8	Freddie Fitzsimmons F. Fitzsimmons	197	133	.597	466	390	3.58	805	168	29	13	2930.0	3,041	1,165	1,390	176	770	29	56	12,359	55	2.47	2.37	1.05	0.54	6.5	6.2	1.30	.271	4.27	91	4.08	102	9.34	-23.4
9	Tommy Bridges T. Bridges	194	138	.584	424	362	3.57	1,674	200	33	10	2826.1	2,675	1,122	1,321	181	1,192	35	47	12,165	59	5.33	3.80	1.40	0.58	13.8	9.8	1.37	.275	4.21	80	3.88	89	8.52	154.4
10	Bobo Newsom B. Newsom	194	202	.490	517	444	4.01	1,948	237	29	18	3435.1	3,428	1,531	1,760	188	1,596	51	49	15,037	56	5.10	4.18	1.22	0.49	13.0	10.6	1.46	.288	4.61	95	3.82	91	8.98	142.5
11	Wes Ferrell W. Ferrell	193	128	.601	374	323	4.04	985	227	17	13	2623.0	2,845	1,177	1,382	132	1,040	23	43	11,568	35	3.38	3.57	0.95	0.45	8.5	9.0	1.48	.289	4.74	87	4.23	93	9.76	97.5
12	Lon Warneke L. Warneke	192	121	.613	445	343	3.18	1,140	192	30	14	2782.1	2,726	984	1,164	175	739	27	66	11,608	50	3.69	2.39	1.54	0.57	9.8	6.4	1.25	.268	3.77	83	3.74	95	8.82	56.7
13	Bucky Walters B. Walters	190	149	.560	400	373	3.18	1,045	236	40	4	2943.2	2,806	1,041	1,233	133	1,052	48	17	12,414	61	3.19	3.22	0.99	0.41	8.4	8.5	1.31	.264	3.77	84	3.77	98	8.58	32.3
14	Lefty Gomez L. Gomez	189	102	.649	368	320	3.34	1,468	173	28	10	2503.0	2,290	930	1,091	138	1,095	19	31	10,729	39	5.28	3.94	1.34	0.50	13.7	10.2	1.35	.269	3.92	79	3.88	94	8.23	70.4
15	Charlie Root C. Root	183	139	.568	563	307	3.61	1,305	156	19	40	2866.0	2,917	1,151	1,318	175	809	67	164	12,156	20	4.10	2.54	1.61	0.55	10.7	6.7	1.30	.280	4.14	91	3.84	95	9.16	68.2
16	Earl Whitehill E. Whitehill	172	152	.531	427	371	4.42	1,074	181	13	9	2807.0	3,097	1,380	1,608	162	1,170	67	38	12,475	40	3.44	3.75	0.92	0.52	8.6	9.4	1.52	.293	5.16	100	4.38	101	9.93	-10.6
17	Bill Lee B. Lee	169	155	.522	448	377	3.53	989	182	29	13	2840.0	2,927	1,115	1,288	135	879	23	42	12,070	54	3.13	2.79	1.13	0.43	8.2	7.3	1.34	.278	4.08	95	3.71	97	9.28	40.8
18	Bump Hadley B. Hadley	161	165	.494	527	355	4.24	1,318	134	14	25	2942.2	2,974	1,385	1,604	167	1,440	63	108	12,999	72	4.03	4.40	0.92	0.51	10.1	11.1	1.50	.280	4.91	96	4.42	102	9.10	-27.5
19	Claude Passeau C. Passeau	160	144	.526	425	325	3.25	1,078	187	25	19	2656.1	2,759	959	1,150	98	704	38	76	11,333	19	3.65	2.39	1.53	0.33	9.5	6.2	1.30	.283	3.90	86	3.25	85	9.35	173.4
20	Alvin Crowder A. Crowder	160	111	.590	383	280	4.12	773	144	16	21	2244.1	2,356	1,028	1,152	134	740	14	65	9,620	20	3.10	2.97	1.04	0.54	8.0	7.7	1.38	.279	4.62	94	4.18	97	9.45	32.7
21	Curt Davis C. Davis	158	131	.547	429	280	3.42	684	141	24	33	2325.0	2,459	884	1,033	142	479	47	111	9,752	20	2.65	1.85	1.43	0.55	7.0	4.9	1.26	.276	4.00	87	3.72	92	9.52	86.1
22	Hal Schumacher H. Schumacher	158	121	.566	391	329	3.36	906	137	26	7	2482.1	2,424	926	1,080	140	902	24	37	10,571	54	3.28	3.27	1.00	0.51	8.6	8.5	1.34	.266	3.92	90	4.02	104	8.79	-48
23	Willis Hudlin W. Hudlin	157	153	.506	483	326	4.43	671	154	11	31	2581.0	2,986	1,271	1,480	117	833	42	102	11,390	40	2.34	2.90	0.81	0.41	5.9	7.3	1.48	.295	5.16	99	4.15	94	10.41	76.5
24	Guy Bush G. Bush	155	109	.587	448	270	3.88	704	135	14	29	2301.0	2,496	993	1,155	127	741	33	111	9,966	47	2.75	2.90	0.95	0.50	7.1	7.4	1.41	.283	4.52	96	4.20	103	9.76	-37.2
25	Dizzy Dean D. Dean	150	83	.644	316	229	3.03	1,163	154	26	31	1963.1	1,916	661	774	95	452	27	77	8,157	12	5.33	2.07	2.57	0.44	14.3	5.5	1.21	.284	3.55	77	3.22	78	8.78	190.5